Role of FSHR gene (rs6165) polymorphism in ovarian stimulation by exogenous FSH of Iraqi infertile women

Abstract

Background: Exogenous FSH has been dispensed to induce follicular growth both when monofollicular development was required and when multifollicular growth was desired to generate multiple mature oocytes. Methods: 210 infertile women and 50 healthy women aged less than 34 years were recruited in present study, the infertile women were separated to three groups based on treatment response (poor ,moderate and high ) responder groups. Results: The outcomes indicated that poor responder group displayed higher levels of FSH and LH also lower levels of AMH,E2,AFC. Conclusion: Polymorphism of FSHR gene(rs6165) was linked to poor response to FSH treatment of Iraqi infertile women.