Droplet flows, termed misting, are significant lubrication flow mechanisms to, in and around the piston assembly. Therefore, these are important in piston assembly tribology and engine performance. Crankcase lubricant degradation rate has been hypothesised to be influenced by lubricant droplet flows through the piston assembly and crankcase, but not previously confirmed. Lubricant was sampled from the sump, top ring zone (TRZ), and mist and aerosol from the crankcase during an extended run. The physical and chemical degradation of these samples was characterised. Droplet flows were intermediate in degradation and fuel dilution between TRZ and sump. Flows with smaller droplet sizes were more degraded that those with larger droplets. The degradation of polymers was dependent on their molecular architecture.