Role of G-protein coupled receptor (GPCRs)/(GPR-120) as an agonists in diabetic wound healing

Yadav, Jagat Pal; Patel, Dinesh Kumar; Pathak, Prateek; Grishina, Maria

doi:10.1016/j.obmed.2022.100466

Cited by 5 publications

(1 citation statement)

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“…Chronic wounds, especially those located on the wounds, can be exacerbated by ischemia or prolonged stress, potentially leading to infection and ultimately requiring amputation [3,4]. Elevated glucose levels are a leading cause of various corneal complications in diabetic patients, including delayed epithelial wound healing [5]. DM disrupts the inflammatory phase of wound healing, which is marked by an increase in pro-inflammatory cytokines, proteases, and reactive oxygen species (ROS), and also impairs the function of various cell types [6,7].…”

Section: Introductionmentioning

confidence: 99%

Based on Clinical Research Matrix Metalloprotease (MMP) Inhibitors to Promote Diabetic Wound Healing

Yadav

2023

Horm Metab Res

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Chronic inflammation is a common factor in obesity, diabetes mellitus, and the complications of diabetes, including diabetic wounds. These ulcers are characterized by persistent lesions that are challenging to heal, significantly decreasing patients’ quality of life and imposing a substantial financial burden on society. MMP are zinc endopeptidases that play a role in wound healing in response to various stimuli, including diabetes mellitus. MMP levels fluctuate throughout the wound healing process in diabetic patients' serum, skin tissues, and wound fluid, indicating their potential as biomarkers for diabetic foot ulcers. Targeting MMP has emerged as a promising strategy for treating diabetic wounds, as these enzymes are involved in critical biological processes related to wound healing, including extracellular matrix secretion, angiogenesis, granulation tissue formation, collagen growth, re-epithelization, inflammatory response, and oxidative stress.

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