Role of GABAA and GABAB receptors and peripheral cholinergic mechanisms in the antinociceptive action of taurine

Serrano, M.I.; Serrano, Juan Bautista Vivero; Guerrero, MCarmen; Fernández, Ana

doi:10.1016/0306-3623(94)90127-9

Cited by 11 publications

(2 citation statements)

References 28 publications

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“…Taurine has been demonstrated to reduce nociceptive behaviour in the rat tail flick test and mouse formalin test and also to inhibit the biting and scratching behaviours elicited by substance P in mice. [4][5][6] In regard to neuropathic pain models, previous reports showed that dietary supplementation with taurine suppressed hyperalgesia in streptozotocin (STZ)-induced diabetic rats 7 and autotomy behaviour in genetically selected Sabra strain rats. 8 However, the precise mechanism and site of taurine action were not well understood.…”

Section: Résumémentioning

confidence: 99%

Antinociceptive effect of intrathecal administration of taurine in rat models of neuropathic pain

Terada

Hara

Haranishi

et al. 2011

Can J Anesth/J Can Anesth

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Section: Résumémentioning

confidence: 99%

Antinociceptive effect of intrathecal administration of taurine in rat models of neuropathic pain

Terada

Hara

Haranishi

et al. 2011

Can J Anesth/J Can Anesth

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“…Taurine, an oxidative metabolite of hypotaurine, has been proven to be antinociceptive in animal models of acute, inflammatory and neuropathic pain (Smullin et al 1990;Silva et al 1993;Serrano et al 1994;Belfer et al 1998;Pellicer et al 2007). Our recent study showed that intrathecally administered taurine has pain-relieving effects via activating glycine receptors in different models of neuropathic pain (Terada et al 2011).…”

Section: Discussionmentioning

confidence: 97%

Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain

et al. 2011

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Hypotaurine is an intermediate in taurine biosynthesis from cysteine in astrocytes. Although hypotaurine functions as an antioxidant and organic osmolyte, its physiological role in the central nervous system remains unclear. This study used behavioral assessments to determine whether hypotaurine influenced nociceptive transmission in acute, inflammatory, and neuropathic pain. The tail flick, paw pressure, and formalin tests were performed in male Sprague-Dawley rats to examine the effects of the intrathecal administration of hypotaurine (100, 200, 400, 600 μg) on thermal, mechanical, and chemical nociception. Chronic constriction injury (CCI) to the sciatic nerve was induced in the rats, and the electronic von Frey test and plantar test were performed to assess the effects on neuropathic pain. To determine which neurotransmitter pathway(s) was involved in the action of hypotaurine, in this study, we examined how the antagonists of spinal pain processing receptors altered the effect of 600 μg hypotaurine. To explore whether hypotaurine affected motor performance, the Rotarod test was conducted. Hypotaurine had antinociceptive effects on thermal, mechanical, and chemical nociception in the spinal cord. In CCI rats, hypotaurine alleviated mechanical allodynia and thermal hyperalgesia. These effects were reversed completely by pretreatment with an intrathecal injection of strychnine, a glycine receptor antagonist. Conversely, hypotaurine did not affect motor performance. This study demonstrated that intrathecal hypotaurine suppressed acute, inflammatory, and neuropathic pain. Hypotaurine may regulate nociceptive transmission physiologically by activating glycinergic neurons in the spinal cord, and it is a promising candidate for treating various pain states.

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8 Taurine

Oja¹,

Saransaari²

2007

Handbook of Neurochemistry and Molecular Neurobiology

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Role of GABAA and GABAB receptors and peripheral cholinergic mechanisms in the antinociceptive action of taurine

Cited by 11 publications

References 28 publications

Antinociceptive effect of intrathecal administration of taurine in rat models of neuropathic pain

Antinociceptive effect of intrathecal administration of taurine in rat models of neuropathic pain

Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain

8 Taurine

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