Role of Gamma Knife Radiosurgery in Multimodality Management of Craniopharyngioma

Saleem, M Abid; Hashim, Abdul Sattar M; Rashid, Azher; Ali, Muhammed

doi:10.1007/978-3-7091-1376-9_9

Cited by 22 publications

(14 citation statements)

References 33 publications

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“…Complete tumor coverage in the radiosurgical target volume resulted in improved PFS, in all his patients as well in mixed tumor group. Saleem et al, [19] observed marked regression of the tumor when the dose was approximately 10 Gy. Overall, reducing the tumor marginal dose results in decreased therapeutic response and increased tumor PG and recurrences, whereas the rate of visual and pituitary function loss decreases and vice-versa.…”

Section: Tumor Responsementioning

confidence: 98%

“…Niranjan et al, [18] in their series of 46 patients, had 3 patients, in whom after initial stereotactic biopsy, gamma knife was offered as the primary treatment for the tumor. Saleem et al, [19] had reported a 33 month child, in whom 3.0 cm 3 tumor was primarily and successfully treated with gamma knife radiosurgery [ Table 1].…”

Section: Indicationsmentioning

confidence: 99%

“…These include neuro-endoscopic fenestration and stereotactic aspiration of the cyst. [19,20] In addition, ventriculo-peritoneal shunting (VP shunt), Ommaya reservoir placement are done to treat the hydrocephalus, associated with the tumor. Patients may present after undergoing conventional external beam radiotherapy, intracavitary P32 instillation and intracystic chemotherapy with Bleomycin.…”

Section: Previous Treatment Before Gamma Knife Radiosurgerymentioning

confidence: 99%

“…Many other series have reported no deterioration of already existing pituitary endocrine status by gamma knife radiosurgery. [19,25,27] Visual function…”

Section: Clinical Response Hormonal Functionmentioning

confidence: 99%

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Role of gamma knife radiosurgery in craniopharyngioma

Patnaik¹,

Mahapatra

2017

IJNS

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Craniopharyngiomas continue to be a challenge to manage, due to difficulty in complete excision and frequent recurrences. The management protocol remains controversial. They have a tendency to invade the normal brain tissues around them and due to their position in suprasellar region in close relationship with vital structures like optic apparatus, pituitary-hypothalamic axis, complete removal is often not feasible without causing serious morbidity and mortality. In this scenario, sub-total excision seems to be a better alternative, which is plagued by early and frequent recurrences. Radiotherapy has been used for increasing the progression free survival and to improve the overall quality of life. Recently Gamma knife radiosurgery has evolved as a promising technique of radiating the residual or recurrent tumor in a single session with great accuracy and precision. This helps in maximizing the radiation dose to the tumor with steep dose fall off to the surrounding tissue, and hence there is better control of the tumor and minimal radiation exposure to surrounding normal, vital brain tissues. We discuss the current strategies of Gamma knife treatment for craniopharyngioma and review the literature.

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Section: Tumor Responsementioning

confidence: 98%

Section: Indicationsmentioning

confidence: 99%

Section: Previous Treatment Before Gamma Knife Radiosurgerymentioning

confidence: 99%

“…Many other series have reported no deterioration of already existing pituitary endocrine status by gamma knife radiosurgery. [19,25,27] Visual function…”

Section: Clinical Response Hormonal Functionmentioning

confidence: 99%

See 2 more Smart Citations

Role of gamma knife radiosurgery in craniopharyngioma

Patnaik¹,

Mahapatra

2017

IJNS

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“…The available data come from series that include both pediatric and adult patients. [64][65][66][67][68][69][70][71][72][73][74][75] The location of these tumors in proximity to the optic apparatus has limited the role of radiosurgery for these tumors. However, these tumors otherwise make ideal radiosurgery targets in that they are often welldefined contrast enhancing lesions with low likelihood of CNS dissemination.…”

Section: Craniopharyngiomamentioning

confidence: 99%

Radiosurgery for Pediatric Brain Tumors

Murphy

Chao

Angelov

et al. 2015

Pediatr Blood Cancer

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The utility of radiosurgery for pediatric brain tumors is not well known. For children, radiosurgery may have an important role for treating unresectable tumors, residual disease, or tumors in the recurrent setting that have received prior radiotherapy. The available evidence demonstrates utility for some children with primary brain tumors resulting in good local control. Radiosurgery can be considered for limited residual disease or focal recurrences. However, the potential toxicities are unique and not insignificant. Therefore, prospective studies need to be performed to develop guidelines for indications and treatment for children and reduce toxicity in this population.

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