Role of gastric mucus secretion, oxinitrergic system and sulfhydryl groups on the gastroprotection elicited by <i>Polygala cyparissias</i> (Polygalaceae) in mice

Klein‐Júnior, Luiz Carlos; Santin, José Roberto; Lemos, Marivane; Silveira, Alessandro Conrado de Oliveira; Rocha, Jady A. R.; Beber, Ana Paula; Wagner, Theodoro Marcel; Bresolin, Tania Mari Bellé; Bella-Cruz, Alexandre; Cechinel‐Filho, Valdir; Andrade, Sérgio Faloni de

doi:10.1111/jphp.12038

Cited by 13 publications

(8 citation statements)

References 40 publications

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“…Astragalin, a pharmacologically active flavonoid isolated from C. cyparissias , has been examined for its antiulcer activity. Results demonstrated that 30 mg/kg dosage of astragalin effectively decreases percentage of lesion area, total area of lesion, and ulcer index in the mice model of gastric secretion [ 97 ].…”

Section: Biological Activities Of Astragalin and Their Mechanisms mentioning

confidence: 99%

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

Riaz

Rasul

Hussain

et al. 2018

Advances in Pharmacological Sciences

169

113

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Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis. This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. It carries out the aforementioned activities by the regulation and modulation of various molecular targets such as transcription factors (NF-κB, TNF-α, and TGF-β1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3, MIP-1α, COX-2, PGE-2, HK2, AChe, SOD, DRP-1, DDH, PLCγ1, and GPX), kinases (JNK, MAPK, Akt, ERK, SAPK, IκBα, PI3K, and PKCβ2), cell adhesion proteins (E-cadherin, vimentin PAR-2, and NCam), apoptotic and antiapoptotic proteins (Beclin-1, Bcl-2, Bax, Bcl-xL, cytochrome c, LC3A/B, caspase-3, caspase-9, procaspase-3, procaspase-8, and IgE), and inflammatory cytokines (SOCS-3, SOCS-5, IL-1β, IL-4, IL-6, IL-8, IL-13, MCP-1, CXCL-1, CXCL-2, and IFN-γ). Although researchers have reported multiple pharmacological applications of astragalin in various diseased conditions, further experimental investigations are still mandatory to fully understand its mechanism of action. It is contemplated that astragalin could be subjected to structural optimization to ameliorate its chemical accessibility, to optimize its absorption profiles, and to synthesize its more effective analogues which will ultimately lead towards potent drug candidates.

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Section: Biological Activities Of Astragalin and Their Mechanisms mentioning

confidence: 99%

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

Riaz

Rasul

Hussain

et al. 2018

Advances in Pharmacological Sciences

169

113

View full text Add to dashboard Cite

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“…It is known that nitric oxide (NO) plays an important role in the defense of the gastric mucosa and is a biological mediator which regulates the secretion of mucus and blood flow (Falcao Hde et al, 2013). In the gastrointestinal tract, NO is also involved in modulating the activity of mast cells together with endogenous prostaglandins (Klein-Junior et al, 2013;Wallace, 2006). Our results showed that the inhibition of NO synthase by L-NAME did not reverse gastroprotection effect of AFHP, thereby suggesting that NO synthesis is not critical to its gastroprotective activity.…”

Section: Discussionmentioning

confidence: 60%

Gastroprotective effect of the aqueous fraction of hydroacetonic leaf extract of Eugenia uniflora L. (Myrtaceae) (pitanga) against several gastric ulcer models in mice

Rodrigues¹,

Da²,

Oluwagbamigbe³

et al. 2017

J. Med. Plants Res.

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Eugenia uniflora L. (Myrtaceae) is popularly known in Brazil as pitanga or ibitanga. The infusion of E. uniflora leaves is being used in folk medicine as anti-diarrheal. The present study sought to evaluate the gastroprotective potential of the aqueous fraction of hydroacetonic leaf extract of pitanga (AFHP). The leaf powder of pitanga was extracted with 50% acetone using an overhead stirrer apparatus at room temperature in which the acetone was removed under reduced pressure and the suspended aqueous. The aqueous layer was freeze-dried to yield a 122 g aqueous fraction, which was stored at-20°C. Preliminary investigation showed that AFHP (100, 300 and 1000 mg/kg, p.o.) is devoid of any behavioral neurotoxic signs. The anti-ulcer activity of AFHP was evaluated in the gastric ulcer models induced by indomethacin, stress and HCl/EtOH in mice. In order to identify possible mechanisms of gastroprotective activity of AFHP, antisecretory activity of this fraction was conducted. The quantification of adhered gastric mucus reduced glutathione (GSH) and the role of nitric oxide (NO) were also investigated. The AFHP showed antiulcer activity in various models of acutely induced ulcers. The intra-duodenal administration of this fraction reduced total acidity and increased pH of the gastric secretion. Oral administration prevented a decrease in the amount of adhered mucus and increased GSH levels. Pretreatment with L-NAME did not affect the gastroprotective effect of AFHP. Our results suggest that AFHP exhibits antiulcer activity that involved an increased in gastric mucus and in the levels of GSH.

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“…There was variability in the study regions for the selected manuscripts, with 25% of the papers coming from Asia ( Moon et al, 2011 ; Asha et al, 2013 ; Manayi et al, 2013 ; Wang et al, 2014 ; Park et al, 2016 ; Ibrahim et al, 2018 ; Kim et al, 2018 ; Lu et al, 2018 ; Saravanakumar et al, 2019 ; Ma X. et al, 2020 ; Das et al, 2020 ), 56.82% from America, of which 40.91% were from South America ( Adzu et al, 2015 ; Almeida et al, 2019 ; Arunachalam et al, 2019 ; Borges et al, 2020 ; da Silva Junior et al, 2016 ; de Cássia dos Santos et al, 2019 ; Garro et al, 2015 ; Klein-Júnior et al, 2013 ; Marcial et al, 2014 ; Mazzolin et al, 2010 ; Minozzo et al, 2016 ; Miranda et al, 2015 ; Mota Da Silva et al, 2015 ; Oliveira et al, 2015 ; Pastene et al, 2014 ; Ribeiro et al, 2013 ; Santos et al, 2012 ; Spósito et al, 2019 ) and 15.91% from North America ( Ankolekar et al, 2011 ; Brown and Jiang, 2013 ; Escobedo Hinojosa et al, 2014 ; Palacios-Espinosa et al, 2014 ; Espinosa-Rivero et al, 2015 ; Egas et al, 2018 ; Gomez-Chang et al, 2018 ), 9.09% of the articles originated from the Africa ( Okeleye et al, 2011 ; Lawal et al, 2014 ; Hamad et al, 2015 ; Fahmy et al, 2020 ), and 9,09% from the Europe ( Bisignano et al, 2013 ; Cardoso et al, 2018 ; Zengin et al, 2018 ; Cesa et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Flavonoids-Rich Plant Extracts Against Helicobacter pylori Infection as Prevention to Gastric Cancer

et al. 2022

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Gastric cancer is the fifth most common and fourth type to cause the highest mortality rates worldwide. The leading cause is related to Helicobacter pylori (H. pylori) infection. Unfortunately, current treatments have low success rates, highlighting the need for alternative treatments against carcinogenic agents, specifically H. pylori. Noteworthy, natural origin products contain pharmacologically active metabolites such as flavonoids, with potential antimicrobial applications.Objective: This article overviews flavonoid-rich extracts’ biological and pharmacological activities. It focuses on using these substances against Helicobacter pylori infection to prevent gastric cancer. For this, PubMed and Science Direct databases were searched for studies that reported the activity of flavonoids against H. pylori, published within a 10-year time frame (2010 to August 2020). It resulted in 1,773 publications, of which 44 were selected according to the search criteria. The plant family primarily found in publications was Fabaceae (9.61%). Among the flavonoids identified after extraction, the most prevalent were quercetin (19.61%), catechin (13.72), epicatechin (11.76), and rutin (11.76). The potential mechanisms associated with anti-H. pylori activity to the extracts were: inhibition of urease, damage to genetic material, inhibition of protein synthesis, and adhesion of the microorganism to host cells.Conclusion: Plant extracts rich in flavonoids with anti-H. pylori potential proved to be a promising alternative therapy source, reinforcing the relevance of studies with natural products.

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Role of gastric mucus secretion, oxinitrergic system and sulfhydryl groups on the gastroprotection elicited by Polygala cyparissias (Polygalaceae) in mice

Abstract: The data suggested that PCAE and PCMF displayed antiulcer activity due to different mechanisms and with the participation of phenolic compounds obtained from the plant.

Cited by 13 publications

References 40 publications

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

Gastroprotective effect of the aqueous fraction of hydroacetonic leaf extract of Eugenia uniflora L. (Myrtaceae) (pitanga) against several gastric ulcer models in mice

Flavonoids-Rich Plant Extracts Against Helicobacter pylori Infection as Prevention to Gastric Cancer

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