Role of gastrointestinal motility/gastric emptying in cisplatin-induced vomiting in pigeon

Ullah, Ihsan; Subhan, Fazal; Rauf, Khalid; Badshah, Amir; Ali, Gowhar

doi:10.5897/ajpp12.530

Cited by 10 publications

(11 citation statements)

References 30 publications

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“…The pigeon is a species that has been used in emesis research for many years and responds to a number of different emetic stimuli including cardiac glycosides [45,46], reserpine [47], sigma receptor ligands [48], and the chemotherapeutic drugs cyclophosphamide [49] and cisplatin [50,51]. In terms of its translational value, it can be used to assay the antiemetic activity of several classes of drugs including 5-HT 3 and NK 1 receptor antagonists [16,52] and glucocorticoids [53].…”

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confidence: 99%

Attenuation of Cisplatin-Induced Emetogenesis by Standardized Bacopa monnieri Extracts in the Pigeon: Behavioral and Neurochemical Correlations

et al. 2014

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Nausea and vomiting are the most distressing and common side effects of cancer chemotherapy which often result in patient noncompliance. In the present study, standardized methanolic and n-butanolic fractions of Bacopa monnieri were evaluated against cisplatin-induced emesis in the pigeon in relation to their activity on central and intestinal neurotransmitters levels. Cisplatin (7.0 mg/kg, i. v.) induced reproducible emesis without lethality in healthy pigeons. The methanolic (10-40 mg/kg) and the bacoside-rich n-butanolic fractions of B. monnieri (5-20 mg/kg), as well as the antioxidant N-(2-mercaptopropionyl) glycine (10 mg/kg), attenuated cisplatin-induced emesis by 66.3% (p < 0.05), 71.6% (p < 0.001), and 76.5% (p < 0.001), respectively, where the standard antiemetic metoclopramide (30 mg/kg) produced a 48.9% reduction (p < 0.01). The methanolic and n-butanolic fractions of B. monnieri at all of the doses tested significantly reduced the serotonin concentration (p < 0.001) in the brain stem and intestine 3 h after cisplatin administration, while at the 18th h, B. monnieri treatments attenuated not only the dopamine upsurge in the area postrema and brain stem (p < 0.05-0.001), but also the intestinal 5-HT concentration (p < 0.01-0.001). B. monnieri treatments alone did not alter the basal neurotransmitters or their metabolites in the brain areas and intestine. The prolonged suppressive effect of B. monnieri treatments on the behavioral signs of cisplatin-induced emesis, the subsequent supportive neural evidence, and the safety and tolerability profile suggest that B. monnieri methanolic and bacoside-rich n-butanolic fractions might be a valuable adjunct in the treatment of emetogenic chemotherapy, and this warrants further study in other models of emesis.

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Attenuation of Cisplatin-Induced Emetogenesis by Standardized Bacopa monnieri Extracts in the Pigeon: Behavioral and Neurochemical Correlations

et al. 2014

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“…Induction of emesis via concentrated sodium chloride solution are found to be linked with other metabolic conditions such as tachycardia, hyper-tension, hypernatremia, and hyperthermia [ 23 ]. In upper GIT, cisplatin-an anticancer drug-result in discharge of serotonin from ECL (enterochromaffin-like cells) resulting in the stimulation of gastrointestinal-VA through 5-HT 3 receptors eventually inducing emesis [ 19 ]. Literature have shown gastro-protective potential of various ethno-medicinal plants in experimented rat models [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…In this study, Healthy Pigeons weighing 240−380 g of either sex were caged and were provided with maintained experimental conditions of temperature (25−30 °C) and light-dark cycles (12−12 h). Availability of fresh water and free access to locally formulated food (Millet + Wheat grains) were ensured throughout the experimental procedure [ 19 ]. Ethical Review Committee (ERC), Department of Pharmacy, Abdul Wali Khan University Mardan, approved the experimental considerations of the study.…”

Section: Methodsmentioning

confidence: 99%

“…At the start of the trial, pigeons used in this model were treated with Distilled water, standard drug, JCR, CRAE and CRME. Then, thirty minutes after treating them with above mentioned subjects, Cisplatin (IM: 6 mg/kg) was administered to these pigeons for induction of emesis [ 19 ]. For all the above mentioned models, experimental pigeons were compared with the negative control group with reference to number & consistency of jerks and emesis episodes, separately.…”

Section: Methodsmentioning

confidence: 99%

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The pharmacological basis of Cuscuta reflexa whole plant as an antiemetic agent in pigeons

et al. 2020

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“…Considering the relevance of DA and 5HT in cisplatin-induced vomiting, this study was designed to evaluate the participation of these monoamine neurotransmitters and their metabolites in cisplatin-induced vomiting, and to examine the impact of Cannabis sativa ( CS ) extract on neurotransmitters implicated in the act of vomiting in specific brain areas and intestine in pigeons. Cannabis sativa hexane fraction was selected based on our previous studies where it was proved to be anti-emetic against cisplatin-induced vomiting in pigeon model ( Ullah et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Suppression of Cisplatin-Induced Vomiting by Cannabis sativa in Pigeons: Neurochemical Evidences

et al. 2018

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Cannabis sativa (CS, family Cannabinaceae) has been reported for its anti-emetic activity against cancer chemotherapy-induced emesis in animal models and in clinics. The current study was designed to investigate CS for potential effectiveness to attenuate cisplatin-induced vomiting in healthy pigeons and to study the impact on neurotransmitters involved centrally and peripherally in the act of vomiting. High-performance liquid chromatography system coupled with electrochemical detector was used for the quantification of neurotransmitters 5-hydroxytryptamine (5HT), dopamine (DA) and their metabolites; Di-hydroxy Phenyl Acetic acid (Dopac), Homovanillic acid (HVA), and 5-hydroxy indole acetic acid (5HIAA) centrally in specific brain areas (area postrema and brain stem) while, peripherally in small intestine. Cisplatin (7 mg/kg i.v.) induce emesis without lethality across the 24 h observation period. CS hexane fraction (CS-HexFr; 10 mg/kg) attenuated cisplatin-induced emesis ∼ 65.85% (P < 0.05); the reference anti-emetic drug, metoclopramide (MCP; 30 mg/kg), produced ∼43.90% reduction (P < 0.05). At acute time point (3rd h), CS-HexFr decreased (P < 0.001) the concentration of 5HT and 5HIAA in the area postrema, brain stem and intestine, while at 18th h (delayed time point) CS-HexFr attenuated (P < 0.001) the upsurge of 5HT caused by cisplatin in the brain stem and intestine and dopamine in the area postrema. CS-HexFr treatment alone did not alter the basal neurotransmitters and their metabolites in the brain areas and intestine except 5HIAA and HVA, which were decreased significantly. In conclusion the anti-emetic effect of CS-HexFr is mediated by anti-serotonergic and anti-dopaminergic components in a blended manner at the two different time points, i.e., 3rd and 18th h in pigeons.

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Role of gastrointestinal motility/gastric emptying in cisplatin-induced vomiting in pigeon

Abstract: In this study we screened various crude fractions of

Cited by 10 publications

References 30 publications

Attenuation of Cisplatin-Induced Emetogenesis by Standardized Bacopa monnieri Extracts in the Pigeon: Behavioral and Neurochemical Correlations

Attenuation of Cisplatin-Induced Emetogenesis by Standardized Bacopa monnieri Extracts in the Pigeon: Behavioral and Neurochemical Correlations

The pharmacological basis of Cuscuta reflexa whole plant as an antiemetic agent in pigeons

Suppression of Cisplatin-Induced Vomiting by Cannabis sativa in Pigeons: Neurochemical Evidences

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