Role of Genetic and Dietary Implications in the Pathogenesis of Global Obesity

Mansoor, Sheikh; Jain, Pooja; Hassan, Nazia; Farooq, Uzma; Mirza, Mohd. Aamir; Pandith, Arshad A.; Iqbal, Zeenat

doi:10.1080/87559129.2021.1874409

Cited by 6 publications

(3 citation statements)

References 109 publications

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“…Interestingly, a local study found that genetic factors were barriers to weight loss for 39% of participants [ 16 ]. Obesity is a multifactorial condition, and genetics certainly play a role; however, this has nothing to do with the ability and possibility to lose weight [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Attitudes Toward Obesity, Willingness to Lose Weight, and Treatment Preferences Among Overweight and Obese Saudi Adults

AlAteeq¹,

AlHomayed²,

AlBuraikan³

et al. 2022

Cureus

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Background: Obesity has become a major health concern worldwide and is associated with several diseases and complications. Losing weight is an effective strategy to improve body mass index and prevent the complications of obesity. However, weight loss is dependent on the attitude of individuals toward obesity as well as their willingness to lose weight.Aim: To explore attitudes toward obesity, willingness to lose weight, and treatment preferences among overweight and obese Saudi adults.Methods: An analytical cross-sectional study was conducted among overweight and obese Saudis. We targeted adults aged 18 years and older, who visited family medicine clinics at King Abdulaziz Medical City for the National Guard in Riyadh, Saudi Arabia. The study was conducted from December 2020 to June 2021 using a self-administered questionnaire.Results: Of the 403 participants, 82.5% were dissatisfied with their current body weight. Controlling chronic disease was a major motive for improving body weight (53.2%), and exercise and diet were the most preferred strategies to lose body weight. Age was a determinant in the attitude and willingness of participants to lose weight (p = 0.0001). Conclusion:Participants in the current study reported high dissatisfaction rates about current weight and willingness to improve body weight. This should encourage healthcare providers to initiate weight status discussions and management with their overweight and obese clients.

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Section: Discussionmentioning

confidence: 99%

Attitudes Toward Obesity, Willingness to Lose Weight, and Treatment Preferences Among Overweight and Obese Saudi Adults

AlAteeq¹,

AlHomayed²,

AlBuraikan³

et al. 2022

Cureus

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“…In general, medical costs may be 30% higher for a person suffering from obesity than a healthy-weight person [ 5 ]. While the etiology of obesity is multifactorial, dietary factors are important contributors to obesity [ 6 , 7 ]. For instance, a Western diet that is high in calories, fat, and sugar content exacerbates obesity and further increases the risk of other comorbid conditions such as type two diabetes mellitus (T2D), inflammatory disorders, and heart disease [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Mechanisms of Curcumin and Its Metabolites in White Adipose Tissue and Cultured Adipocytes

Islam,

Scoggin,

Gong

et al. 2023

Nutrients

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The plant-derived polyphenol curcumin alleviates the inflammatory and metabolic effects of obesity, in part, by reducing adipose tissue inflammation. We hypothesized that the benefits of curcumin supplementation on diet-induced obesity and systemic inflammation in mice occur through downregulation of white adipose tissue (WAT) inflammation. The hypothesis was tested in adipose tissue from high-fat diet-induced obese mice supplemented with or without curcumin and in 3T3-L1 adipocytes treated with or without curcumin. Male B6 mice were fed a high-fat diet (HFD, 45% kcal fat) with or without 0.4% (w/w) curcumin supplementation (HFC). Metabolic changes in these mice have been previously reported. Here, we determined the serum levels of the curcumin metabolites tetrahydrocurcumin (THC) and curcumin-O-glucuronide (COG) using mass spectrometry. Moreover, we determined interleukin 6 (IL-6) levels and proteomic changes in LPS-stimulated 3T3-L1 adipocytes treated with or without curcumin by using immunoassays and mass spectrometry, respectively, to gain further insight into any altered processes. We detected both curcumin metabolites, THC and COG, in serum samples from the curcumin-fed mice. Both curcumin and its metabolites reduced LPS-induced adipocyte IL-6 secretion and mRNA levels. Proteomic analyses indicated that curcumin upregulated EIF2 and mTOR signaling pathways. Overall, curcumin exerted anti-inflammatory effects in adipocytes, in part by reducing IL-6, and these effects may be linked to the upregulation of the mTOR signaling pathway, warranting additional mechanistic studies on the effects of curcumin and its metabolites on metabolic health.

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“…At college, students' eating preferences and habits lead towards weight gain and other life-lasting issues like uncontrolled sugar and blood levels. As per WHO reports about 80% of the previously discussed chronic diseases are due to lifestyle and dietary factors (Mansoor et al, 2021). Likewise, students have to face several problems involving health affecting one's eating practices resulting in obesity.…”

Section: Introductionmentioning

confidence: 99%

Impact of Dietary Habits on Health Status of College Going Students in Punjab

Ashraf

Amir

Syed³

et al. 2021

HSSR

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Purpose of the study: The core objective of this study was to analyze the effect of dietary habits on the health status of college-going students. Methodology: Two districts of Punjab were selected randomly namely Faisalabad and Rahim Yar Khan. Two public sector colleges were selected purposively from each district i.e. one male and one female keeping in mind low strength and high strength were selected. The population of these colleges was 5372 while the sample size was 189. A well-structured questionnaire was developed on a google form. Collected data were processed through SPSS software for standard deviation, frequency, mean, and weighted score, and rank order. Main Findings: It was found that most of the respondents were female students and the majority of the student’s family monthly income was Rs. 10,000 – 20,000. The majority of the respondents were not suffering from any disease. The majority of respondents were those who have never eaten snacks in between their meals. Respondents who use to eat breakfast every day were ranked No. 1. Majority of the respondents were using full fat milk, soft drinks, and meat with visible fats. Most of the students were involved with healthy life habits i.e. doing physical activity, consuming fruits and greens. Application of the study: This study can also be used to determine the dietary habit impact on the health status of college-going students in other districts of Punjab. Novelty/ originality of the study: This study has provided an overview of different diseases affecting the health of college-going students. In the context of the current portfolio, the results of the current study will create awareness regarding healthy nutrition for improving the health status of the student.

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Role of Genetic and Dietary Implications in the Pathogenesis of Global Obesity

Cited by 6 publications

References 109 publications

Attitudes Toward Obesity, Willingness to Lose Weight, and Treatment Preferences Among Overweight and Obese Saudi Adults

Attitudes Toward Obesity, Willingness to Lose Weight, and Treatment Preferences Among Overweight and Obese Saudi Adults

Anti-Inflammatory Mechanisms of Curcumin and Its Metabolites in White Adipose Tissue and Cultured Adipocytes

Impact of Dietary Habits on Health Status of College Going Students in Punjab

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