Role of Ghrelin in the Regulation of Vasopressin Release in Conscious Rats

Ishizaki, Seiji; Murase, Takashi; Sugimura, Yoshihisa; Kakiya, Satoshi; Yokoi, Hisashi; Tachikawa, Kazushige; Arima, Hiroshi; Miura, Yoshitaka; Oiso, Yutaka

doi:10.1210/endo.143.5.8804

Cited by 41 publications

(24 citation statements)

References 27 publications

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“…the reason for this may be that GhRp-2 might have a different effect on AVp secretion independent of osmolality and hemodynamic factors, unlike ghrelin, probably because GhRp-2 is an exogenous ligand that binds the GhS receptor, while ghrelin is an endogenous ligand that binds the GhS receptor [2]. this difference supports the notion that, for Acth secretion, GhRp-2 acts via cRF [7], while ghrelin acts via AVp [12], and ghrelin stimulates secretion of gastric juice with gastrin, whereas GhRp-2 has no such effects [23]. Moreover, AVp levels increase significantly with the itt [17][18][19].…”

Section: Discussionsupporting

confidence: 53%

“…secreted from the stomach and circulates in the bloodstream under fasting conditions [5], and the GhSs have a stimulating effect not only on Acth via cRh in animals [6,7] and humans [4,[8][9][10], but also on arginine vasopressin (AVp) in animals [6,11,12] and humans [9,10]. interestingly, ghrelin plays a stimulatory role in AVp release mediated by neuropeptide y (npy) neurons in rat [11,12].…”

mentioning

confidence: 99%

“…interestingly, ghrelin plays a stimulatory role in AVp release mediated by neuropeptide y (npy) neurons in rat [11,12]. GhRp-2 is known to increase food intake in humans [13] via many neurotransmitters, such as ghrelin [5] and npy [14,15].…”

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confidence: 99%

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GH-releasing Peptide-2 does not Stimulate Arginine Vasopressin Secretion in Healthy Men

et al. 2010

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Abstract. Ghrelin has a stimulating effect on arginine vasopressin (AVp). however, it is not known whether GhRp-2, a synthetic ghrelin receptor agonist, also has a stimulating effect on AVp release in men. to determine whether the GhRp-2 test is useful for assessing AVp secretion, blood Acth, Gh, FSh, Lh, pRL, tSh and AVp levels, as well as glucose, osmolality, sodium and hematocrit, were measured before and 15, 30, 45 and 60 min after an intravenous bolus of 100 µg GhRp-2 in 10 healthy men with and without fasting. blood pressure was measured at 15-min intervals. AVp secretion was not stimulated by the GHRP-2 test with and without fasting. There were no significant differences in hematocrit, blood pressure and plasma osmolality before and after GFRP-2 injection, although significant (p<0.001) peak blood Gh, and Acth and pRL levels were observed 30 and 15 min after GhRp-2 injection with and without fasting, respectively, and the maximal peaks were significantly (p<0.05) higher with fasting than without fasting. these results suggest that AVp secretion is not stimulated by the GhRp-2 test both with and without fasting, though Gh, Acth and pRL levels were higher with than without fasting.

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Section: Discussionsupporting

confidence: 53%

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confidence: 99%

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GH-releasing Peptide-2 does not Stimulate Arginine Vasopressin Secretion in Healthy Men

et al. 2010

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“…Thus, native AG stimulates AVP release from rat posterior pituitary gland, probably via an indirect action mediated by NPY neurons (Ishizaki et al 2002, Wren et al 2002. Notably, AG-induced ACTH release has also been suggested to be mediated by the AG action on AVP secretion, because the AG-induced AVP rise precedes the increase in ACTH and cortisol levels in response to AG injection in healthy men (Coiro et al 2005).…”

Section: Posterior Pituitary Hormonesmentioning

confidence: 98%

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Gahete

Rincón-Fernández

Villa-Osaba

et al. 2013

Journal of Endocrinology

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Ghrelin is a 28-amino acid acylated hormone, highly expressed in the stomach, which binds to its cognate receptor (GHSR1a) to regulate a plethora of relevant biological processes, including food intake, energy balance, hormonal secretions, learning, inflammation, etc. However, ghrelin is, in fact, the most notorious component of a complex, intricate regulatory system comprised of a growing number of alternative peptides (e.g. obestatin, unacylated ghrelin, and In1-ghrelin, etc.), known (GHSRs) and, necessarily unknown receptors, as well as modifying enzymes (e.g. ghrelin-O-acyl-transferase), which interact among them as well as with other regulatory systems in order to tightly modulate key (patho)-physiological processes. This multiplicity of functions and versatility of the ghrelin system arise from a dual, genetic and functional, complexity. Importantly, a growing body of evidence suggests that dysregulation in some of the components of the ghrelin system can lead to or influence the development and/or progression of highly concerning pathologies such as endocrine-related tumors, inflammatory/cardiovascular diseases, and neurodegeneration, wherein these altered components could be used as diagnostic, prognostic, or therapeutic targets. In this context, the aim of this review is to integrate and comprehensively analyze the multiple components and functions of the ghrelin system described to date in order to define and understand its biological and (patho)-physiological significance.

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“…Furthermore, ICV administration of ghrelin has been shown to increase plasma vasopressin level without a significant change in arterial pressure in conscious rats. 8 It has also been reported that intravenous injection of human ghrelin elicits a decrease in blood pressure without an increase in heart rate (HR) in healthy men. 9 In addition, plasma ghrelin concentration is increased in patients with cachexia associated with chronic heart failure.…”

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confidence: 99%

Central Ghrelin Modulates Sympathetic Activity in Conscious Rabbits

et al. 2002

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Abstract-Ghrelin is an orexigenic peptide originally isolated from the stomach. Intravenous administration of ghrelin has been shown to elicit a decrease in arterial pressure without a significant change in heart rate (HR), suggesting that ghrelin may act on the central nervous system to modulate sympathetic activity. The aim of the present study was to determine the central effects of ghrelin on cardiovascular and sympathetic responses in conscious rabbits. Key Words: baroreceptors Ⅲ blood pressure Ⅲ central nervous system Ⅲ ghrelin Ⅲ nervous system, sympathetic renal G hrelin, an acylated 28-residue peptide originally isolated from the rat stomach, is an endogenous ligand for the growth hormone (GH) secretagogue receptor. 1,2 Although ghrelin is likely to regulate pituitary GH secretion along with GH-releasing hormone and somatostatin, 2,3 GH secretagogue receptors have also been identified in hypothalamic neurons and in the brainstem. 4,5 Intracerebroventricular (ICV) administration of ghrelin has been shown to generate a dose-dependent increase in food intake and body weight, 6,7 suggesting that ghrelin participates in the regulation of food intake and GH secretion. Furthermore, ICV administration of ghrelin has been shown to increase plasma vasopressin level without a significant change in arterial pressure in conscious rats. 8 It has also been reported that intravenous injection of human ghrelin elicits a decrease in blood pressure without an increase in heart rate (HR) in healthy men. 9 In addition, plasma ghrelin concentration is increased in patients with cachexia associated with chronic heart failure. 10 These previous findings suggest that ghrelin may participate not only in feeding behavior but also in cardiovascular and sympathetic regulation. Although ghrelin has been reported to have a vasodilatory effect in humans, 11 the underlying mechanisms of depressor response induced by intravenous injection of ghrelin have not yet been determined. Because the depressor response was not accompanied by tachycardia, it is likely that mechanisms other than direct vasodilating effects, at least in part, are involved in this depressor response. To clarify the mechanisms for this depressor response, the effects of ghrelin on sympathetic activity and on the baroreceptor reflex should be determined. We hypothesized that intravenous administration of ghrelin acts at the central nervous system to modulate the sympathetic nervous system, resulting in a decrease in arterial pressure without tachycardia. Accordingly, in the present study, we focused on the central effect of ghrelin on sympathetic activity and baroreceptor reflex. To evaluate the sympathetic nervous system precisely, the present study was conducted on conscious rabbits with direct recording of renal sympathetic nerve activity (RSNA), because the sympathetic nervous system and baroreceptor reflex are greatly affected by anesthesia. 12,13

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Role of Ghrelin in the Regulation of Vasopressin Release in Conscious Rats

Cited by 41 publications

References 27 publications

GH-releasing Peptide-2 does not Stimulate Arginine Vasopressin Secretion in Healthy Men

GH-releasing Peptide-2 does not Stimulate Arginine Vasopressin Secretion in Healthy Men

Ghrelin gene products, receptors, and GOAT enzyme: biological and pathophysiological insight

Central Ghrelin Modulates Sympathetic Activity in Conscious Rabbits

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