Role of ginger in the treatment of Schistosoma mansoni infection a histopathological studies

El-Sameih, Mahmoud A.; Hassan, F.; Abed, Gamal Hassan; Omar, Hossam El-Din M.

doi:10.5455/ajvs.244185

Cited by 5 publications

(5 citation statements)

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“…In addition, various structures, including villi in the ileum inspected portions, appeared normal. Our findings agree with those of Mahmoud et al (2014) , who investigated the effects of ginger and cinnamon on the gut and liver of intestines attacked by parasites.…”

Section: Discussionsupporting

confidence: 92%

Consequences of dietary cinnamon and ginger oils supplementation on blood biochemical parameters, oxidative status, and tissue histomorphology of growing Japanese quails

Abd El-Hack,

AboElMaati,

Abusudah

et al. 2024

Poultry Science

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Section: Discussionsupporting

confidence: 92%

Consequences of dietary cinnamon and ginger oils supplementation on blood biochemical parameters, oxidative status, and tissue histomorphology of growing Japanese quails

Abd El-Hack,

AboElMaati,

Abusudah

et al. 2024

Poultry Science

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“…Garlic and turmeric extracts exhibited the highest inhibitory effect in relation to the ST3 viability. The garlic activity was also observed with other protozoan parasites, such as Giardia lamblia [ 66 , 67 ], Cryptosporidium parvum [ 68 ], and Entamoeba histolytica [ 23 ] . According to the literature, Blastocystis ST7 has been shown to be more resistant to anti-parasitic drugs [ 69 , 70 ] and against the host innate immune response [ 71 ] compared to ST1 and ST4 isolates.…”

Section: Discussionmentioning

confidence: 99%

The influence of plant extracts on viability of ST3 and ST7 subtypes of Blastocystis sp.

Kot,

Michaliszyn,

Kalisińska

et al. 2024

Gut Pathog

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Blastocystis sp. is one of the most frequently detected protozoa during stool specimen examination. In the last decade, the studies about the pathogenic potential of Blastocystis sp. have intensified. Additionally, treatment approaches against this parasite are still disputable. The study aimed to investigate the in vitro activity of the substances of natural origin against two subtypes (ST) of Blastocystis sp.—ST3 and ST7. Garlic and turmeric extracts exhibited the highest inhibitory effect in relation to the ST3 viability. While horseradish and turmeric were found to be the most effective extracts to the ST7 viability. The study showed that ginger, garlic, horseradish, and turmeric extracts have potent antimicrobial activity against Blastocystis ST3 and ST7, with the half-maximal inhibitory concentration (IC50) ranging from 3.8 to 4.8 µg/ml and from 3.3 to 72.0 µg/ml, respectively, and thus may be useful in the prevention and control of Blastocystis infections. Additionally, this research confirmed that Blastocystis ST7 is more resistant to the selected plant extracts treatment than Blastocystis ST3 which in consequence may bring some difficulties in its eradication.

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“…The bioactive compounds of cinnamon include, cinnamyl acetate , cinnamaldehyde , and benzyl benzoate among others. The disease in which cinnamon compounds have been employed as a drug include, gastrointestinal (GI) and various parasitic infections [ 45 ]. These diseases are caused by a wide range of pathogenic microbes including fungal and bacterial strains.…”

Section: Discussionmentioning

confidence: 99%

Assessing the efficacy of cinnamon compounds against H. pylori through molecular docking, MD Simulations and ADMET analyses

Sarwar,

Zahra,

Awan

et al. 2024

PLoS ONE

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Antibiotics are the drugs that are used for the management of microbial diseases. However, these conventional synthetic drugs can harmfully affect the human health. Since phytochemicals are extracted from natural sources and, are hence relatively safer for human health, they are the enticing alternatives in this regard. Cinnamon is also one of those plants which is being employed as herbal medication for centuries against certain microbial infections due its significant therapeutic effectiveness. A well-known pathogenic bacterium called H. pylori causes a wide range of illnesses in human body. This pathogen’s pathogenicity is determined by certain virulent proteins. In this study, some of such proteins, which included virB4, virB8, and virB9 were selected to evaluate the therapeutic efficiency of cinnamon compounds. These proteins were identified in different isolates of H. pylori. The structural modelling of all these proteins were performed initially in order to proceed them for molecular docking analysis. While, the docking studies illustrated that one of the cinnamon compounds, cinnamyl acetate, showed significant binding interactions with virB4 and virB9. However, benzyl benzoate which is another cinnamon compound, docked well with virB8. Afterwards, the MD simulations were incorporated to explore the interaction motions and structural stability of all the docked complexes. In this regard, the resultant maps of Bfactor, eigenvalues and elastic network model, among other factors ensured the structural stabilities of all the respective complexes. After these crucial estimations, benzyl benzoate and cinnamyl acetate underwent the ADMET investigation to assess their pharmacokinetic characteristics. SwissADME and ADMETLab 2.0 server were employed for this investigation. The compiled findings these servers revealed that both, benzyl benzoate and cinnamyl acetate, exhibited a significant level of pharmacokinetic and drug-likeness conformity.

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Role of ginger in the treatment of Schistosoma mansoni infection a histopathological studies

Cited by 5 publications

References 0 publications

Consequences of dietary cinnamon and ginger oils supplementation on blood biochemical parameters, oxidative status, and tissue histomorphology of growing Japanese quails

Consequences of dietary cinnamon and ginger oils supplementation on blood biochemical parameters, oxidative status, and tissue histomorphology of growing Japanese quails

The influence of plant extracts on viability of ST3 and ST7 subtypes of Blastocystis sp.

Assessing the efficacy of cinnamon compounds against H. pylori through molecular docking, MD Simulations and ADMET analyses

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