Role of ginkgo biloba extract in acquired sensorineural hearing loss

Kumar, Aman; Raizada, R. M.; Chaturvedi, V. N.

doi:10.1007/bf03006187

Cited by 6 publications

(1 citation statement)

References 2 publications

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“…In human studies, supplementation with Ginkgo biloba extract EGb 761 during chemotherapy with cisplatin showed significant hearing protection, as measured by distortion product otoacoustic emission (DPOAE) tests, compared to the control group [140]. Similarly, in another trial using Ginkocer, a Ginkgo biloba supplement, ARHL patients experienced an average of 15.56% improvement in hearing [141]. Moreover, coal miners exposed to blast noise damage and treated with Ginkgo biloba through a tympanic injection, in combination with hyperbaric oxygen therapy, exhibited significant improvement in acoustic response rates compared to those who only received traditional therapy [142].…”

Section: Ginkgo Bilobamentioning

confidence: 99%

Unveiling the Role of Oxidative Stress in Cochlear Hair Cell Death: Prospective Phytochemical Therapeutics against Sensorineural Hearing Loss

Gill,

Dowker-Key,

Hedrick

et al. 2024

IJMS

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Hearing loss represents a multifaceted and pervasive challenge that deeply impacts various aspects of an individual’s life, spanning psychological, emotional, social, and economic realms. Understanding the molecular underpinnings that orchestrate hearing loss remains paramount in the quest for effective therapeutic strategies. This review aims to expound upon the physiological, biochemical, and molecular aspects of hearing loss, with a specific focus on its correlation with diabetes. Within this context, phytochemicals have surfaced as prospective contenders in the pursuit of potential adjuvant therapies. These compounds exhibit noteworthy antioxidant and anti-inflammatory properties, which hold the potential to counteract the detrimental effects induced by oxidative stress and inflammation—prominent contributors to hearing impairment. Furthermore, this review offers an up-to-date exploration of the diverse molecular pathways modulated by these compounds. However, the dynamic landscape of their efficacy warrants recognition as an ongoing investigative topic, inherently contingent upon specific experimental models. Ultimately, to ascertain the genuine potential of phytochemicals as agents in hearing loss treatment, a comprehensive grasp of the molecular mechanisms at play, coupled with rigorous clinical investigations, stands as an imperative quest.

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Section: Ginkgo Bilobamentioning

confidence: 99%