Role of Glia in the Regulation of Sleep in Health and Disease

Garofalo, Stefano; Picard, Katherine; Limatola, Cristina; Nadjar, Agnès; Pascual, Olivier; Tremblay, Marie‐Ève

doi:10.1002/cphy.c190022

Cited by 49 publications

(36 citation statements)

References 326 publications

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“…In critical developmental periods, microglia participate to the brain maturation by regulating glio-and neuronogenesis, synapse formation, maturation and function, by clearing the brain from extracellular debris and by refining its synaptic connections, notably through their phagocytic activity and release of trophic factors, as well as pro-and anti-inflammatory cytokines (Kettenmann et al, 2013;Tay et al, 2017b). Once neuronal circuits are formed, mature microglia play important roles in neuronal circuit remodelling, learning, memory and the adaptation of the brain and behaviour to lifestyle factors including the diet, physical activity, sleep patterns, and other external influences (Garofalo et al, 2020;Madore et al, 2020). More recently, microglia were also found to contribute to developmental myelination and remyelination (for instance in multiple sclerosis) through the release of trophic factors regulating oligodendrocyte progenitor's formation and maturation, as well as removal of myelin debris required for remyelination (Domingues et al, 2016;Hughes and Appel, 2020;Traiffort et al, 2020).…”

Section: Astrocytes and Microglia: The Gatekeepers And Defenders Of Tmentioning

confidence: 99%

Neuropathobiology of COVID-19: The Role for Glia

Tremblay

Madore

Bordeleau

et al. 2020

Front. Cell. Neurosci.

145

120

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SARS-CoV-2, which causes the Coronavirus Disease 2019 (COVID-19) pandemic, has a brain neurotropism through binding to the receptor angiotensin-converting enzyme 2 expressed by neurones and glial cells, including astrocytes and microglia. Systemic infection which accompanies severe cases of COVID-19 also triggers substantial increase in circulating levels of chemokines and interleukins that compromise the blood-brain barrier, enter the brain parenchyma and affect its defensive systems, astrocytes and microglia. Brain areas devoid of a blood-brain barrier such as the circumventricular organs are particularly vulnerable to circulating inflammatory mediators. The performance of astrocytes and microglia, as well as of immune cells required for brain health, is considered critical in defining the neurological damage and neurological outcome of COVID-19. In this review, we discuss the neurotropism of SARS-CoV-2, the implication of neuroinflammation, adaptive and innate immunity, autoimmunity, as well as astrocytic and microglial immune and homeostatic functions in the neurological and psychiatric aspects of COVID-19. The consequences of SARS-CoV-2 infection during ageing, in the presence of systemic comorbidities, and for the exposed pregnant mother and foetus are also covered.

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Section: Astrocytes and Microglia: The Gatekeepers And Defenders Of Tmentioning

confidence: 99%

Neuropathobiology of COVID-19: The Role for Glia

Tremblay

Madore

Bordeleau

et al. 2020

Front. Cell. Neurosci.

145

120

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“…Furtheremore, one study repored that late DLMO reflecting delayed phase of melatonin secretion was dysfunction of glial cell [35]. Glial cell might be important contributors to the regulation of sleep-wake cycle [44]. Glia-mediated neuroinflammation and glial ceel dysfunction could lead to the disturbance of sleep-wake cycle [44].…”

Section: Discussionmentioning

confidence: 99%

Changes Caused by the Melatonergic System in Young Patients with Mood Disorders: A Literature Review

Lee

Moon

2021

Mood Emot

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The abnormalities caused by the melatonergic system have been associated with psychiatric disorders, such as Alzheimer's dementia and schizophrenia, as well as with the pathogenesis of mood disorders. Abnormal melatonin secretion has been observed in the early phase of mood disorders in young patients and high-risk adults. This review summarizes and discusses the findings of studies that have investigated the melatonergic system in children, adolescents, and young adults with mood disorders. Furthermore, the factors associated with the changes caused by the melatonergic system during the early stage of mood disorders are evaluated.

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“…29 The questionnaire contained 17 terms, and the total scores ranged from 0 to 52, where higher scores indicate greater depressive severity. In China, the corresponding grades to depressive states are as follows: no depression (0-7), mild depression (8)(9)(10)(11)(12)(13)(14)(15)(16)(17), moderate depression (18)(19)(20)(21)(22)(23), and severe depression .…”

Section: Depression Anxiety and Comprehensive Cognition Evaluationsmentioning

confidence: 99%

“…74 There is little evidence that CID presents organic brain damage. 20,21 Therefore, insomnia may have a direct impact upon dysfunction of astrocytes, which may begin at the early course or even the prodromal stage of the illness.…”

Section: Gfapmentioning

confidence: 99%

“…Moreover, astrocytes determine the urge to sleep by clearing toxic substances through the glymphatic system. 19,20 Serum S100 calcium-binding protein B (S100B) levels are neurobiochemical markers and can reflect the severity of astrocyte damage. Our preliminary study showed that patients with CID had significantly increased serum S100B levels, while their concentrations did not change significantly after effective therapy.…”

Section: Introductionmentioning

confidence: 99%

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<p>Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study</p>

Zhang¹,

Li²,

Zhang³

et al. 2020

NSS

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The objective of this study was to investigate whether the serum biomarkers S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) change in patients with chronic insomnia disorder (CID), and if this is the case, whether the altered levels of these serum biomarkers are associated with poor sleep quality and cognitive decline in CID. Patients and Methods: Fifty-seven CID outpatients constituted the CID group; thirty healthy controls (HC) were also enrolled. Questionnaires, polysomnography, Chinese-Beijing Version of Montreal Cognitive Assessment (MoCA-C) and Nine Box Maze Test (NBMT) were used to assess their sleep and neuropsychological function. Serum S100B, GFAP, BDNF, and GDNF were evaluated using enzyme-linked immunosorbent assay. Results: The CID group had higher levels of S100B and GFAP and lower levels of BDNF and GDNF than the HC group. Spearman correlation analysis revealed that poor sleep quality, assessed by subjective and objective measures, was positively correlated with S100B level and negatively correlated with BDNF level. GFAP level correlated positively with poor subjective sleep quality. Moreover, S100B and GFAP levels correlated negatively with general cognitive function assessed using MoCA-C. GFAP level correlated positively with poor spatial working memory (SWM) in the NBMT; BDNF level was linked to poor SWM and object recognition memory (ORcM) in the NBMT. However, principal component analysis revealed that serum S100B level was positively linked to the errors in object working memories, BDNF and GDNF concentrations were negatively linked with errors in ORcM, and GFAP concentration was positively correlated with the errors in the SWM and spatial reference memories. Conclusion: Serum S100B, GFAP, BDNF, and GDNF levels were altered in patients with CID, indicating astrocyte damage, and were associated with insomnia severity or/and cognitive dysfunction.

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Role of Glia in the Regulation of Sleep in Health and Disease

Cited by 49 publications

References 326 publications

Neuropathobiology of COVID-19: The Role for Glia

Neuropathobiology of COVID-19: The Role for Glia

Changes Caused by the Melatonergic System in Young Patients with Mood Disorders: A Literature Review

<p>Astroglial Mechanisms Underlying Chronic Insomnia Disorder: A Clinical Study</p>

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