Role of glutamate in the development of visual pathways

Majumdar, Sriparna

doi:10.3389/fopht.2023.1147769

Cited by 4 publications

(3 citation statements)

References 39 publications

(45 reference statements)

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“…Glutamate is a major excitatory neurotransmitter in the retina, including the chicken retina [337], where it was found to regulate the release of adenosine, GABA, and vitamin C [92,207,271]. The activation of ionotropic glutamate receptors, such as AMPA, kainite, and NMDA receptors, can promote a dose-dependent release of purines in cultures of chick retinal cells.…”

Section: Glutamate and Adenosinementioning

confidence: 99%

The Healthy and Diseased Retina Seen through Neuron–Glia Interactions

Tempone,

Borges-Martins,

César

et al. 2024

IJMS

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The retina is the sensory tissue responsible for the first stages of visual processing, with a conserved anatomy and functional architecture among vertebrates. To date, retinal eye diseases, such as diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, glaucoma, and others, affect nearly 170 million people worldwide, resulting in vision loss and blindness. To tackle retinal disorders, the developing retina has been explored as a versatile model to study intercellular signaling, as it presents a broad neurochemical repertoire that has been approached in the last decades in terms of signaling and diseases. Retina, dissociated and arranged as typical cultures, as mixed or neuron- and glia-enriched, and/or organized as neurospheres and/or as organoids, are valuable to understand both neuronal and glial compartments, which have contributed to revealing roles and mechanisms between transmitter systems as well as antioxidants, trophic factors, and extracellular matrix proteins. Overall, contributions in understanding neurogenesis, tissue development, differentiation, connectivity, plasticity, and cell death are widely described. A complete access to the genome of several vertebrates, as well as the recent transcriptome at the single cell level at different stages of development, also anticipates future advances in providing cues to target blinding diseases or retinal dysfunctions.

show abstract

Section: Glutamate and Adenosinementioning

confidence: 99%

The Healthy and Diseased Retina Seen through Neuron–Glia Interactions

Tempone,

Borges-Martins,

César

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Glutamate is a major excitatory neurotransmitter in the retina, including the chicken retina [340], where it was found to regulate the release of adenosine, GABA, and vitamin C [94,210,274]. Activation of ionotropic glutamate receptors as AMPA, kainite and NMDA receptors is able to promote a dose-dependent release of purines in cultures of chick retinal cells.…”

Section: Glutamate and Adenosinementioning

confidence: 99%

The Healthy and Diseased Retina Seen through Neuron-Glia Interactions

Tempone,

Borges-Martins,

César

et al. 2024

Preprint

View full text Add to dashboard Cite

The retina is the sensory tissue responsible for the first stages of visual processing, with a conserved anatomy and functional architecture among vertebrates. To date, retinal eye diseases, such as diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, glaucoma and others, affect nearly 170 million people worldwide, resulting in vision loss and blindness. To tackle retinal disorders, the developing retina has been explored as a versatile model to study intercellular signaling, as it presents a broad neurochemical repertoire. Retina, dissociated and arranged as typical cultures, as mixed or neuron- and glia-enriched, and/or organized as neurospheres or as organoids are valuable to understand both neuronal and glial compartments which have contributed to reveal roles and mechanisms of transmitter systems as well as antioxidants, trophic factors, and extracellular matrix proteins. Overall, contributions in understanding neurogenesis, tissue development, differentiation, connectivity, plasticity, and cell death are widely described. A complete access to the genome of several vertebrates, as well the recent transcriptome at the single cell level at different stages of development also anticipates future advances in providing cues to target blinding diseases or retinal dysfunctions.

show abstract

“…Glutamate is a major excitatory neurotransmitter in the retina, including the chicken retina [341], where it was found to regulate the release of adenosine, GABA, and vitamin C [94, 211,275]. Activation of ionotropic glutamate receptors as AMPA, kainite and NMDA receptors is able to promote a dose-dependent release of purines in cultures of chick retinal cells.…”

Section: Glutamate and Adenosinementioning

confidence: 99%

The Healthy and Diseased Retina Seen through Neuron-Glia Interactions

Tempone,

Borges-Martins,

César

et al. 2023

Preprint

View full text Add to dashboard Cite

The retina is the sensory tissue responsible for the first stages of visual processing, with a conserved anatomy and functional architecture among vertebrates. To date, retinal eye diseases, such as diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, glaucoma and others, affect nearly 170 million people worldwide, resulting in vision loss and blindness. To tackle retinal disorders, the embryonic retina has been explored as a versatile model to study development, with a broad neurochemical repertoire, approached in the last decades in terms of signaling and diseases. Retina, dissociated and arranged as typical cultures are valuable to understand both neuronal and glial compartments, as mixed or neuron- and glia-enriched, and/or organized as neurospheres and/or as organoids which have contributed to reveal mechanisms between transmitter systems as well as antioxidants, trophic factors, and extracellular matrix proteins. Overall, contributions in understanding neurogenesis, tissue development, differentiation, connectivity, plasticity, and cell death are widely described. A complete access to the genome of several vertebrates, as well the recent transcriptome at the single cell level at different stages of development also anticipates future advances in providing cues to target blinding diseases or retinal dysfunctions.

show abstract

Role of glutamate in the development of visual pathways

Cited by 4 publications

References 39 publications

The Healthy and Diseased Retina Seen through Neuron–Glia Interactions

The Healthy and Diseased Retina Seen through Neuron–Glia Interactions

The Healthy and Diseased Retina Seen through Neuron-Glia Interactions

The Healthy and Diseased Retina Seen through Neuron-Glia Interactions

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