Role of Glutamine in the Management of Oral Mucositis in Patients with Cancer: A Meta-Analysis of Randomized Controlled Trials

Use of oral glutamine in radiation‑induced adverse effects in patients with thoracic and upper aerodigestive malignancies: Results of a prospective observational study

“…The favorable efficacy and low toxicity of oral gln observed in clinical trials provide a strong rationale for large RCTs in patients with cancer receiving RT and/or CT ( 45 , 46 ). Recent meta-analyses specifically focusing on OM in such groups of patients concluded that gln reduces the severity of OM and the incidence of severe OM (grade 3 and 4) ( 47 , 48 ). In addition, gln reduced the incidence of opioid analgesic use, feeding tube use, hospitalization and treatment interruption caused by OM ( 46 ).…”

“…Use of opioids according to the presence of adverse events. --------------------------------------------------- ------------------------------------------------------------------------------------------------- meta-analyses specifically focusing on OM in such groups of patients concluded that gln reduces the severity of OM and the incidence of severe OM (grade 3 and 4) (47,48). In addition, gln reduced the incidence of opioid analgesic use, feeding tube use, hospitalization and treatment interruption caused by OM (46).…”

NO, way to go: critical amino acids to replenish nitric oxide production in treating mucositis

“…Since the review from 2019, results of one retrospective study, three RCTs and five meta-analyses have been published [56][57][58][59][60][61][62]63 & ,64 & ]. In the retrospective study, the effect of parenteral glutamine administration via parenteral nutrition on duration of mucositis in HSCT patients was assessed [60].…”

“…Since the review from 2019, results of one retrospective study, three RCTs and five meta-analyses have been published [56–62,63 ▪ ,64 ▪ ].…”

“…Three meta-analysis including RCTs were published in the past 2 years [61,63 ▪ ,64 ▪ ]. All concern oral mucositis.…”