Role of glutathione, glutathione transferase, and glutaredoxin in regulation of redox-dependent processes

Калинина, Е. В.; Чернов, Н. Н.; Novichkova, Maria

doi:10.1134/s0006297914130082

Cited by 173 publications

(146 citation statements)

References 178 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…These laboratory changes were consistent with increased oxidative stress and impaired methylation capacity in children with ASD ( James et al 2004). As shown in Figure 1, these abnormalities are related to three interconnected metabolic pathways known collectively as methionine transmethylation/transsulfuration metabolism (Hirsch et al 2008;Kalinina et al 2014;Watson et al 2014).…”

Section: Introductionmentioning

confidence: 58%

Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism

Widjaja

et al. 2016

Journal of Child and Adolescent Psychopharmacology

106

View full text Add to dashboard Cite

Objective: Children with autism spectrum disorder (ASD) have been reported to have reduced ability to methylate DNA and elevated markers of oxidative stress. We sought to determine if methyl B12, a key metabolic cofactor for cellular methylation reactions and antioxidant defense, could improve symptoms of ASD. Methods: A total of 57 children with ASD were randomly assigned to 8 weeks of treatment with methyl B12 (75 lg/kg) or saline placebo every 3 days in a subcutaneous injection. The primary outcome measure was overall improvement in symptoms of ASD as measured by the Clinical Global Impressions-Improvement (CGI-I) score. Secondary outcome measures included changes in the Aberrant Behavior Checklist (ABC) and the Social Responsiveness Scale (SRS). Laboratory measures of methionine methylation and antioxidant glutathione metabolism were assessed at baseline and 8 weeks.Results: A total of 50 children (mean age 5.3 years, 79% male) completed the study. The primary outcome measure -the clinician rated CGI-I score -was statistically significantly better (lower) in the methyl B12 group (2.4) than in the placebo group (3.1) (0.7 greater improvement in the methyl B12 group, 95% CI 1.2-0.2, p = 0.005). Clinical improvement among children treated with methyl B12 was positively correlated with increases in plasma methionine ( p = 0.05), decreases in S-adenosyl-lhomocysteine (SAH) ( p = 0.007) and improvements in the ratio of S-adenosylmethionine (SAM) to SAH ( p = 0.007), indicating an improvement in cellular methylation capacity. No improvements were observed in the parent-rated ABC or SRS. Conclusions: Methyl B12 treatment improved clinician-rated symptoms of ASD that were correlated with improvements in measures of methionine metabolism and cellular methylation capacity. Clinical Trial Registry: Efficacy Study of Subcutaneous Methyl B12 in Children with Autism: NCT01039792 (clinical trials.gov1).

show abstract

Section: Introductionmentioning

confidence: 58%

Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism

Widjaja

et al. 2016

Journal of Child and Adolescent Psychopharmacology

106

View full text Add to dashboard Cite

show abstract

“…Система глутатіону є однією із активних складових антиоксидантної системи захисту організму, яка відіграє значну роль у пригні-ченні патологічного процесу, її виснаження може призводити до виникнення серйозних цитотоксичних і деструктивних ушкоджень [8]. Вивчення змін у глутатіоновій системі важливе для пошуку нових фармакологічних засобів, зокрема природного походження, які здатні корегувати стан окисного стресу.…”

Section: вступunclassified

“…Найбільш важливий компонент глутатіон-залежної антиоксидантної системи GSH, який швидко мобілізується в разі підвищеного вмісту активних форм кисню та відновлює їх у реакціях з утворенням окисненого глу-татіону (GSSG), у такий спосіб забезпечує резистентність клітин до ПОЛ, вільних ра-дикалів, алкілування білків, і попереджує пошкодження структури ДНК. Враховуючи безпосередню участь глутатіону у багатьох процесах життєдіяльності клітини, в тому числі диференціації, проліферації, апоптозу, порушення його гомеостазу може свідчити про розвиток патологічних змін на фоні роз-витку ожиріння [8,17].…”

Section: результати та їх обговоренняunclassified

Status of Glutathione-Dependent Link of Blood Antioxidant System Under Application of Fenugreek Seed Powder in Animals With Experimental Obesity

Konopelnyuk¹,

Коt²,

Koval³

et al. 2016

Fiziol Zh

View full text Add to dashboard Cite

“…The reversal of S-glutathionylation (i.e. de-glutathionylation) is catalyzed by glutaredoxin (Grx) at the expense of GSH as a cosubstrate (Kalinina et al, 2014).…”

Section: S-nitrosation Vs S-glutathionylation: Differences Similarimentioning

confidence: 99%

Regulation of protein function by S-nitrosation and S-glutathionylation: processes and targets in cardiovascular pathophysiology

Belcastro

Gaucher

Corti

et al. 2017

Biological Chemistry

View full text Add to dashboard Cite

Decades of chemical, biochemical and pathophysiological research have established the relevance of post-translational protein modifications induced by processes related to oxidative stress, with critical reflections on cellular signal transduction pathways. A great deal of the so-called 'redox regulation' of cell function is in fact mediated through reactions promoted by reactive oxygen and nitrogen species on more or less specific aminoacid residues in proteins, at various levels within the cell machinery. Modifications involving cysteine residues have received most attention, due to the critical roles they play in determining the structure/function correlates in proteins. The peculiar reactivity of these residues results in two major classes of modifications, with incorporation of NO moieties (S-nitrosation, leading to formation of protein S-nitrosothiols) or binding of low molecular weight thiols (S-thionylation, i.e . in particular S-glutathionylation, S-cysteinylglycinylation and S-cysteinylation).A wide array of proteins have been thus analyzed in detail as far as their susceptibility to either modification or both, and the resulting functional changes have been described in a number of experimental settings. The present review aims to provide an update of available knowledge in the field, with a special focus on the respective (sometimes competing and antagonistic) roles played by protein S-nitrosations and S-thionylations in biochemical and cellular processes specifically pertaining to pathogenesis of cardiovascular diseases.

show abstract

Role of glutathione, glutathione transferase, and glutaredoxin in regulation of redox-dependent processes

Cited by 173 publications

References 178 publications

Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism

Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism

Status of Glutathione-Dependent Link of Blood Antioxidant System Under Application of Fenugreek Seed Powder in Animals With Experimental Obesity

Regulation of protein function by S-nitrosation and S-glutathionylation: processes and targets in cardiovascular pathophysiology

Contact Info

Product

Resources

About