Role of glutathione S-transferase M1, T1 and P1 gene polymorphisms in childhood acute lymphoblastic leukemia susceptibility in a Turkish population

Güven, Mehmet; Unal, Selin; Erhan, Duygu; Özdemir, Nihal; Barış, Safa; Çelkan, Tiraje; Bostancı, Merve; Batar, Bahadır

doi:10.1016/j.mgene.2015.06.002

Cited by 12 publications

(15 citation statements)

References 34 publications

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“…However, outcome of individual studies in this review showed that in distribution of GSTM1 genotype, three had increase risk of association with null genotype [19,27,44] and two had no significant difference in prevalence of null genotype [22,24] whiles one study with a gender stratified analysis showed that the null genotype was over-represented in boys [21]. In environmental exposures of chemical pesticides and tobacco smoke 83.3% shows increase risk of childhood ALL [20,23,[27][28][29][30][31][32][33]] and 16.7% shows no association with childhood acute lymphoblastic leukemia [34,35].…”

Section: Discussionmentioning

confidence: 69%

GSTM1 and GSTT1 Genetic Susceptibility and Interaction with Chemical Exposures in Childhood Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis

Sesay¹,

Katiella²,

Ngoya³

et al. 2018

Cancer Sci Res

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Background: The glutathione s-transferase genes play an important role in the detoxification of carcinogenic substances, and null mutations of these genes are linked to increase in acute lymphoblastic leukemia (ALL) due to an increase in susceptibility to environmental exposures of toxins and carcinogens, and chemical exposures like tobacco smoke and pesticides are common carcinogenic substances that children could be vulnerable to as risk of developing childhood ALL. Objectives: The aim of this study is to analyze the effect of glutathione s-transferase mu1 and theta1 genetic susceptibility and interaction of chemical pesticide and tobacco smoke exposures on childhood ALL. Data collection and Analysis: A total of 22 published case-controls were included in the meta-analysis of over forty thousand participants with 14974 cases and 25841 controls.

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Section: Discussionmentioning

confidence: 69%

GSTM1 and GSTT1 Genetic Susceptibility and Interaction with Chemical Exposures in Childhood Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis

Sesay¹,

Katiella²,

Ngoya³

et al. 2018

Cancer Sci Res

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“…Previous studies have reported on the correlation between the GSTP1 gene polymorphism and several kinds of cancers, such as lung cancer, acute lymphoblastic leukemia, breast cancer, skin cancer, head and neck cancer, and oral cancer (Choudhury et al, 2015;Guven et al, 2015;Jaramillo-Rangel et al, 2015;Krüger et al, 2015;Lei et al, 2015;Sharma et al, 2015). For example, Sharma et al (2015) conducted a study in an Indian population, and reported that the null GSTT1 and wild-type GSTP1 genotypes were associated with an increased risk of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

“…For example, Sharma et al (2015) conducted a study in an Indian population, and reported that the null GSTT1 and wild-type GSTP1 genotypes were associated with an increased risk of lung cancer. However, Guven et al (2015) suggested that the GST variants might not influence the risk of developing childhood acute lymphoblastic leukemia in a Turkish population. Furthermore, Jaramillo-Rangel et al (2015) reported that the GSTM1-null genotype was associated with breast cancer risk in a Mexican population.…”

Section: Discussionmentioning

confidence: 99%

“…Gene variations in GSTs may alter the expression levels of enzymes and affect their detoxification abilities. Previous studies have reported that the GSTT1, GSTM1, and GSTP1 gene polymorphisms are involved in the development of several kinds of cancers, such as lung cancer, acute lymphoblastic leukemia, breast cancer, skin cancer, head and neck cancer, and oral cancer (Sharma et al, 2015;Guven et al, 2015;Jaramillo-Rangel et al, 2015;Lei et al, 2015;Choudhury et al, 2015;Krüger et al, 2015). Here, we conducted a case-control study to investigate the association between the GSTT1, GSTM1, and GSTP1 gene polymorphisms and development of osteosarcoma in a Chinese population.…”

Section: Introductionmentioning

confidence: 93%

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Contribution of the GSTP1 gene polymorphism to the development of osteosarcoma in a Chinese population

Qu¹,

Wu²,

R³

2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the associations between GSTT1, GSTM1, and GSTP1 gene polymorphisms and development of osteosarcoma in a Chinese population. Between January 2013 and February 2015, 153 patients diagnosed with osteosarcoma and 252 control subjects were enrolled in the current study from the Orthopedic Hospital of the Second Hospital of Jilin University. The GSTM1, GSTT1, and GSTP1 gene polymorphisms were detected by polymerase chain reaction coupled with restriction fragment length polymorphism analysis. As determined by a multiple-logistic regression analysis, the Val/Val genotype of GSTP1 was associated with a significantly increased risk of osteosarcoma compared to that of the Ile/Ile genotype, with an odds ratio (OR) = 3.39, and a 95% confidence interval (CI) = 1.45-8.13. Moreover, the Ile/Val+Val/Val genotype of GSTP1 was correlated with a marginally significant increased risk of osteosarcoma compared to that of the Ile/Ile genotype (OR = 1.65, 95%CI = 1.08-2.53). However, we did not find any significant associations between the GSTM1 and GSTT1 gene polymorphisms and osteosarcoma risk. In conclusion, our results suggest that the GSTP1 gene polymorphism is associated with an increased risk of osteosarcoma, whereas the GSTM1 and GSTT1 gene polymorphisms may not influence the development of this cancer.

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“…GSTM1, GSTT1, and GSTP1 are members of three subfamilies of the GST enzyme. Deletion of the GSTM1 or GSTT1 genes and non-synonymous GSTP1 Ile105Val could affect the expression and activity of the enzymes, and thereby lead to impaired detoxification and cancers (Broekman et al, 2014;Rao et al, 2014;Guven et al, 2015). Previous studies have reported the association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer (Tripathi et al, 2008;Nguyen et al, 2010;Yadav et al, 2010;Zhang et al, 2011;García-González et al, 2012) with inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors

2017

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ABSTRACT. Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals' susceptibility to cancers. We aimed to investigate the association between GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of gastric cancer in a Chinese population. In addition, we also examined the effect of gene-environmental interactions, and their effect on risk of this cancer. Between July 2013 and June 2015, we recruited 242 gastric cancer patients and 396 healthy controls for our study. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to characterize genetic polymorphisms in GSTM1, GSTT1, and GSTP1. We observed that the Val/Val genotype of GSTP1 was associated with increased risk of gastric cancer when compared with the Ile/Ile genotype (OR = 3.19, 95%CI = 1.84-5.56). Moreover, the Val allele of GSTP1 was associated with higher susceptibility to gastric cancer as compared with the Ile allele (OR = 1.52, 95%CI = 1.19-1.93). However, GSTM1 and GSTT1 polymorphisms did not affect the development of gastric cancer. In conclusion, our study indicated that GSTP1 Ile105Val, but not GSTM1 and GSTT1 polymorphisms, was associated with risk of gastric cancer.

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Role of glutathione S-transferase M1, T1 and P1 gene polymorphisms in childhood acute lymphoblastic leukemia susceptibility in a Turkish population

Cited by 12 publications

References 34 publications

GSTM1 and GSTT1 Genetic Susceptibility and Interaction with Chemical Exposures in Childhood Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis

GSTM1 and GSTT1 Genetic Susceptibility and Interaction with Chemical Exposures in Childhood Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis

Contribution of the GSTP1 gene polymorphism to the development of osteosarcoma in a Chinese population

Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors

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