Role of glycemic control on lipid profile in patients with type 2 diabetes mellitus-a cross-sectional study in tertiary care hospital of West Bengal

Chakrabarti, Phalguni; Samaddar, Aparajita; Chakraborty, Arup; Mukhopadhyay, Debanjan; Pathak, Swapan

doi:10.5455/njppp.2022.12.12441202113122021

Cited by 3 publications

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“…In patients with type 2 diabetes the risk of diabetic complications was strongly associated with raised blood pressure. Any reduction in blood pressure is likely to reduce the risk of complications, with the lowest risk being in those with systolic blood pressure less than 120 mm Hg (Stratton et al, 2000), also blood1 pressure1 is one of the risk1 factors affecting1 type 2 1diabetes patients according to the1 study (DeFronzo et al, 2015) (Chakrabarti et al, 2022;Gupta, 2016;Ouchi et al, 2022). In order to track a diabetic's glycemic management, glycated hemoglobin (HbA1c) levels are routinely monitored.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of leptin hormone and Tumor necrosis factor levels in patients with type two diabetes mellites

Mahdi¹,

Thuwaini²,

Abbas³

2023

UTJsci

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Background: Type 2 diabetes mellitus (T2DM) is a leading cause of mortality and morbidity worldwide. Leptin, an adipokine with the primary function of regulating energy balance, is found to mediate insulin secretion and sensitivity in peripheral tissues. Aims: Hence, we aimed to determine the role of leptin in the development of insulin resistance (IR) in newly diagnosed T2DM patients and determine tumor necrosis factoralpha (TNF-?). Materials and methods: A case control study a total of 80 patients and 50 control groups, used Cobas E311 device to measure glucose, whereas HbA1c used D-10 hemoglobin Hba1c device whereas other parameters used ELISA methods were used to analyses 130 samples Results: Highly significant increase level of Fasting blood sugar, hemoglobin A1c, Insulin, Leptin and HOMA- insulin resistance whereas significant decrease level of TNF alpha and , Plasminogen activator inhibitors -1 in patient type two diabetes mellitus compared to the control group. Conclusion: increased the level of leptin levels while TNF-? levels were decreased in type 2 diabetes patients.

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Section: Resultsmentioning

confidence: 99%

Evaluation of leptin hormone and Tumor necrosis factor levels in patients with type two diabetes mellites

Mahdi¹,

Thuwaini²,

Abbas³

2023

UTJsci

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Assessment of fasting plasma glucose, insulin, insulin resistance and glycated haemoglobin as markers of glycemic control in apparently healthy older adults in Nnewi

Ogbodo,

Onah,

Amah

et al. 2024

IJFCM

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: Biochemical changes in glycemic indices have been linked to aging, and many individuals have asymptomatic hyperglycemia as they get older. This leads to metabolic dysregulation, which heightens vulnerability to a number of age-related chronic conditions, such as diabetes mellitus. : This cross-sectional study assessed the levels of fasting plasma glucose, insulin, insulin resistance and glycated haemoglobin as markers of glycemic control in apparently healthy older adults in Nnewi. A total of 144 participants were involved in this study: 72 older persons and 72 control subjects. The older adults were aged 45 to 75; while the control group was composed of individuals aged 18 to 30. Six milliliters (6 ml) of fasting venous blood samples were collected from each participant for the determination of insulin (INS), glycated haemoglobin (HbA1c), and plasma glucose (FPG) levels. Enzyme-linked immunosorbent assay was used to evaluate INS, resin ion-exchange was used to estimate HbA1c, and glucose oxidase peroxidase was used to determine FPG. The Homeostasis Model Assessment Index (HOMA-IR) was used to calculate insulin resistance. : The mean FPG, HbA1c, INS and HOMA-IR were significantly higher in the older adults compared to control subjects respectively (p<0.05). Also, the mean FPG, HbA1c, INS and HOMA-IR were significantly higher in the older adult males and females compared to the control male and female subjects respectively (p<0.05). There was significant moderate positive correlation between the level of FBS Vs HbA1c (r=0.484, P-value = 0.000) and strong positive correlation between the level of Insulin Vs HOMA-IR (r=0.980, P-value = 0.000) in the control group. Also, strong significant positive correlations were observed between FPG and HbA1c (r=0.704, P-value = 0.000), FPG and HOMA-IR (r=0.778, P-value = 0.000), Insulin and HOMA-IR (r=0.778, P-value = 0.000) with a moderate significant positive correlation found between HbA1c Vs HOMA-IR (r=0.557, P-value = 0.000) in the older adults. This study showed that glycemic indices tend to become altered with advancing in age.

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Changes in Haematological Parameters and Lipid Profiles in Diabetes Mellitus: A Literature Review

Mbah,

Bwititi,

Gyawali

et al. 2024

Cureus

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Role of glycemic control on lipid profile in patients with type 2 diabetes mellitus-a cross-sectional study in tertiary care hospital of West Bengal

Cited by 3 publications

References 0 publications

Evaluation of leptin hormone and Tumor necrosis factor levels in patients with type two diabetes mellites

Evaluation of leptin hormone and Tumor necrosis factor levels in patients with type two diabetes mellites

Assessment of fasting plasma glucose, insulin, insulin resistance and glycated haemoglobin as markers of glycemic control in apparently healthy older adults in Nnewi

Changes in Haematological Parameters and Lipid Profiles in Diabetes Mellitus: A Literature Review

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