Role of gold nanoparticle from Cinnamomum verum against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced mice model

Li, Ling; Jiang, Ye; Liu, Yongdan; Li, Huimin; Bari, Ahmed; Ullah, Riaz; Xue, Jianyang

doi:10.1016/j.jphotobiol.2019.111657

Cited by 21 publications

(14 citation statements)

References 30 publications

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“…Several synthetic and natural substances, as summarized in Table 1, are utilized to attenuate dopaminergic neuron loss through suppressing TLR signaling pathway and NF-κB (Café-Mendes et al, 2017;Cheng & Zhu, 2019;Li et al, 2018;Ling et al, 2019;Lv et al, 2019;Xu et al, 2017;Yang et al, 2019;Yu et al, 2016;Zhang & Xu, 2018 ;Zhang et al, 2016 It has been demonstrated that aggregated α-synuclein by binding to CD36 on microglia, which by recruiting Fyn kinase can activate protein kinase C-delta (PKC-δ), thereby propagating translocation of NF-κB p65 subunit to the nucleus. In the nucleus, p65 subunit enhances expression of IL-1β and NLR family pyrin domain containing 3 (NLRP3) inflammasome (Panicker et al, 2019) (Figure 1).…”

Section: Inflammationmentioning

confidence: 99%

“…Several synthetic and natural substances, as summarized in Table 1, are utilized to attenuate dopaminergic neuron loss through suppressing TLR signaling pathway and NF‐κB (Café‐Mendes et al., 2017; Cheng & Zhu, 2019; Li et al., 2018; Ling et al., 2019; Lv et al., 2019; Xu et al., 2017; Yang et al., 2019; Yu et al., 2016; Zhang & Xu, 2018 ; Zhang et al., 2016).…”

Section: Evidence Into Involvement Of Nf‐κb Family In Pdmentioning

confidence: 99%

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Nuclear factor‐kappa B (NF‐κB) in pathophysiology of Parkinson disease: Diverse patterns and mechanisms contributing to neurodegeneration

Dolatshahi

Hameghavandi

Sabahi

et al. 2021

Eur J of Neuroscience

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Parkinson's disease (PD) is the second most common neurodegenerative disease and the most common movement disorder, which causes morbidity and mortality and imposes a large burden (Kowal et al., 2013). Sporadic form of PD occurs more abundantly in aging population and causes symptoms like rigidity, bradykinesia, akinesia, resting tremor, motor imbalance, etc (Davie, 2008). It is characterized by selective degeneration and progressive loss of dopaminergic (DA) neurons in substantia nigra pars compacta (SNpc) which give rise to axonal processes innervating striatum (Surmeier, 2018). A myriad of etiologies contribute to DA neuron loss including inflammation, oxidative stress, autophagy, neurotransmission alterations, metabolic changes, etc. However, the

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Section: Inflammationmentioning

confidence: 99%

Section: Evidence Into Involvement Of Nf‐κb Family In Pdmentioning

confidence: 99%

Nuclear factor‐kappa B (NF‐κB) in pathophysiology of Parkinson disease: Diverse patterns and mechanisms contributing to neurodegeneration

Dolatshahi

Hameghavandi

Sabahi

et al. 2021

Eur J of Neuroscience

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“…[34] Another study has indicated that gold nanoparticles (NPs) synthesized from C. verum may protect against MPTP-induced oxidative stress, neuroinflammation, and motor deficits in MPTP-treated rat models of PD, as evaluated by pole-climbing and grasp strength tests. [45] The administration of these NPs (5 or 10 mg/kg) before MPTP injection was associated with downregulation of TLR/NF-κB signaling pathway, lower expression of toll-like receptor 2 (TLR-2), TLR-4, and reduced levels of proinflammatory cytokines in the brain tissue of rats, including TNF-α, IL-1β, and IL-6, as well as decreased ROS generation and increased SOD activity. [45] The TLR/NF-κB pathway plays a critical role in PD pathogenesis, via its implication in neuroinflammation, apoptosis, autophagy, and mitochondrial impairment.…”

Section: Verum Powder 3 H After Mptp Intoxication Has Been Associatedmentioning

confidence: 99%

“…[45] The administration of these NPs (5 or 10 mg/kg) before MPTP injection was associated with downregulation of TLR/NF-κB signaling pathway, lower expression of toll-like receptor 2 (TLR-2), TLR-4, and reduced levels of proinflammatory cytokines in the brain tissue of rats, including TNF-α, IL-1β, and IL-6, as well as decreased ROS generation and increased SOD activity. [45] The TLR/NF-κB pathway plays a critical role in PD pathogenesis, via its implication in neuroinflammation, apoptosis, autophagy, and mitochondrial impairment. [46] Along with improvement in motor performances, NP treatment also improved weight loss associated with MPTP mouse model of PD.…”

Section: Verum Powder 3 H After Mptp Intoxication Has Been Associatedmentioning

confidence: 99%

“…[46] Along with improvement in motor performances, NP treatment also improved weight loss associated with MPTP mouse model of PD. [45] Weight loss has been attributed to poor nutrition, higher risk of developing dyskinesia and frailty, resulting in potentially higher mortality and poor quality of life, [47] suggesting that cinnamon extracts may also provide benefits in this clinical aspects of PD. Metal NPs attached to appropriate pharmaceutical agents possess interesting physicochemical characteristics, representing a novel drug delivery strategy for neurodegenerative diseases.…”

Section: Verum Powder 3 H After Mptp Intoxication Has Been Associatedmentioning

confidence: 99%

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Neuroprotective potential of cinnamon and its metabolites in Parkinson's disease: Mechanistic insights, limitations, and novel therapeutic opportunities

Angelopoulou

Paudel

Piperi

et al. 2021

J Biochem & Molecular Tox

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Parkinson's disease (PD) is the most common neurodegenerative movement disorder with obscure etiology and no disease‐modifying therapy to date. Hence, novel, safe, and low cost‐effective approaches employing medicinal plants are currently receiving increased attention. A growing body of evidence has revealed that cinnamon, being widely used as a spice of unique flavor and aroma, may exert neuroprotective effects in several neurodegenerative diseases, including PD. In vitro evidence has indicated that the essential oils of Cinnamomum species, mainly cinnamaldehyde and sodium benzoate may protect against oxidative stress‐induced cell death, reactive oxygen species generation, and autophagy dysregulation, thus acting in a potentially neuroprotective manner. In vivo evidence has demonstrated that oral administration of cinnamon powder and sodium benzoate may protect against dopaminergic cell death, striatal neurotransmitter dysregulation, and motor deficits in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine mouse models of PD. The underlying mechanisms of its action include autophagy regulation, antioxidant effects, upregulation of Parkin, DJ‐1, glial cell line‐derived neurotrophic factor, as well as modulation of the TLR/NF‐κB pathway and inhibition of the excessive proinflammatory responses. In addition, in vitro and in vivo studies have shown that cinnamon extracts may affect the oligomerization process and aggregation of α‐synuclein. Herein, we discuss recent evidence on the novel therapeutic opportunities of this phytochemical against PD, indicating additional mechanistic aspects that should be explored, and potential obstacles/limitations that need to be overcome, for its inclusion in experimental PD therapeutics.

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Green synthesis of gold nanoparticles for immune response regulation: Mechanisms, applications, and perspectives

Cai

Huang

et al. 2021

J Biomedical Materials Res

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Immune responses are involved in the pathogenesis of many diseases, including cancer, autoimmune diseases, and chronic inflammation. These responses are attributed to immune cells that produce cytokines, mediate cytotoxicity, and synthesize antibodies. Gold nanoparticles (GNPs) are novel agents that intervene with immune responses because of their unique physical‐chemical properties. In particular, GNPs enhance anti‐tumour activity during immunotherapy and eliminate excessive inflammation in autoimmune diseases. However, GNPs synthesized by conventional methods are toxic to living organisms. Green biosynthesis provides a safe and eco‐friendly method to obtain GNPs from microbes or plant extracts. In this review, we describe several patterns for green GNP biosynthesis. The applications of GNPs to target immune cells and modulate the immune response are summarized. In particular, we elaborate on how GNPs regulate innate immunity and adaptive immunity, including inflammatory signaling and immune cell differentiation. Finally, perspectives and challenges in utilizing green biosynthesized GNPs for novel therapeutic approaches are discussed.

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Role of gold nanoparticle from Cinnamomum verum against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced mice model

Cited by 21 publications

References 30 publications

Nuclear factor‐kappa B (NF‐κB) in pathophysiology of Parkinson disease: Diverse patterns and mechanisms contributing to neurodegeneration

Nuclear factor‐kappa B (NF‐κB) in pathophysiology of Parkinson disease: Diverse patterns and mechanisms contributing to neurodegeneration

Neuroprotective potential of cinnamon and its metabolites in Parkinson's disease: Mechanistic insights, limitations, and novel therapeutic opportunities

Green synthesis of gold nanoparticles for immune response regulation: Mechanisms, applications, and perspectives

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