At this historical stage of development, Ukraine is going through the most difficult times since the period of gaining its independence. The logic of state administration, financial and credit relations, social guidelines and the foreign policy of our country in general has changed. The sectors of education and science, in which not always positive changes are taking place, were also affected by such changes. Rather, on the contrary, there is a trend of stagnation in education caused by weak institutional support, and imperfect personnel and financial policies. The aggressive policy of the Russian Federation in relation to our country caused a powerful surge of internal and external migration of the population, including highly professional and narrowly qualified workers who were involved in educational and scientific processes and proved their effectiveness. In such conditions, it becomes necessary to determine the orientations of the organizational and innovative management of financial and personnel support of academies, institutes, universities and other educational institutions in the conditions of the restoration of intellectual potential. It is especially important to develop a methodology for its assessment and forecasting. In this context, the article proposes ways of evaluating, forecasting and improving the organizational and innovative management of financial and personnel support of higher education institutions. In the process of writing the article, economic and mathematical methods, tools and models were used, in particular two-factor regression models, Farrar-Glober tools, the method of least squares, and Fisher's F-criterion analysis. Taking into account the trends of forecasting financial and personnel support in order to improve the management of higher education institutions, managers should pay attention to the need to attract investments to improve the quality of scientific research.