Role of Green Tea in Reducing Epidermal Thickness upon Ultraviolet Light-B Injury in BALB/c Mice

Hassan, Snur Ma; Hussein, Adel; Saeed, Azad K

doi:10.1155/2015/890632

Cited by 18 publications

(15 citation statements)

References 32 publications

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“…Because epidermal keratinocytes are at a high risk of UVBinduced damages, the epidermal thickness was determined as a measure of keratinocyte proliferation (Hassan et al, 2015). Representative images of hematoxylin and eosinstained skin are shown in Figure 3c.…”

Section: Resultsmentioning

confidence: 99%

Chemoprotective Effects of Dietary Grape Powder on UVB Radiation-Mediated Skin Carcinogenesis in SKH-1 Hairless Mice

Singh

Mintie

Ndiaye

et al. 2019

Journal of Investigative Dermatology

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Skin cancer is the most frequently diagnosed cancer in the United States, and solar UVR is an established causative factor for approximately 90% of these cases. Despite efforts aimed at UV protection, including use of sunscreen and clothing, annual cases of skin cancer continue to rise. Here, we report that dietary grape powder mitigates UVB-mediated skin carcinogenesis in an SKH-1 hairless mouse model. Using a UVB initiationpromotion protocol, whereby mice were exposed to 180 mJ/cm 2 UVB two times per week for 28 weeks, we determined the effects of a grape powder-fortified diet (3% or 5%) on skin carcinogenesis. Grape powder consumption at both doses resulted in marked inhibition in tumor incidence, as well as a delay in onset of tumorigenesis. Molecular analyses of skin and tumor tissue showed that grape powder-mediated protective response against UVB-induced skin cancer was accompanied by enhanced DNA damage repair, reduced proliferation, increased apoptosis, and modulations in several oxidative stress markers specifically related to inhibition of oxidative stress and increased reactive oxygen species metabolism. NRF2, an activator of cellular antioxidant response, was decreased by grape powder feeding, suggesting a supportive role in tumor cell survival. Overall, our study suggested that dietary grape, containing several antioxidants in natural amalgamation, may protect against UVB-mediated skin carcinogenesis.

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Section: Resultsmentioning

confidence: 99%

Chemoprotective Effects of Dietary Grape Powder on UVB Radiation-Mediated Skin Carcinogenesis in SKH-1 Hairless Mice

Singh

Mintie

Ndiaye

et al. 2019

Journal of Investigative Dermatology

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“…However, according to the study of Yi et al and Hassan et al, tea has a protective role for cancer (Hassan, Hussein, & Saeed, 2015;Lin et al, 2014). This difference may be due to difference in dietary habits of these regions, particularly the type of tea consumed, method of making and level of consumption.…”

Section: Discussionmentioning

confidence: 99%

A Study of Food Consumption Patterns in Patients with Gastric Cancer in Mazandaran

Hajiahmadi¹,

Shokri‐Shirvani²,

Moslemi³

et al. 2017

JMBR

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Gastric cancer is one of the most common types of cancer. There are geographical and racial differences in the prevalence of gastric cancer in different societies. The present study aims to investigate the food consumption patterns in patients with gastric cancer in Mazandaran.This case-control study was conducted among 100 patients with gastric cancer and 200 healthy controls. Two questionnaires including demographic information, and food frequency were completed by all participants.The mean frequency of consuming raw onions, fried onions, cucumbers and salted vegetables, red meat (beef and lamb), eggs, burgers, pizza, soy, pasteurized milk, yogurt, ice cream, liquid oil, cream, tea, pumpkin and sunflower seeds, chocolate and dates in the case group was more than control group. Findings of the current research showed that some foods such asvegetables, fish, rice and dairy are extensively found in the dietary patterns in northern of Iran.These are considered as preventive factorsin the incidence of gastric cancer.

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“…For example, animal and in vitro research suggests that green tea phenolics can remove or repair UVB‐induced DNA damage and inflammation (Nichols & Katiyar ; Katiyar ), inhibit UV‐induced increased epidermal thickness (Hassan et al . ), reduce the breakdown of collagen (Song et al . ; Bae et al .…”

Section: Popular Nutraceutical Ingredients and Skin Ageingmentioning

confidence: 99%

“…Based on animal and in vitro data, it has been suggested that, when applied topically, they can act as a sunscreen, but research has suggested that mechanisms other than direct absorption of UV may be important (Nichols & Katiyar 2010). For example, animal and in vitro research suggests that green tea phenolics can remove or repair UVBinduced DNA damage and inflammation (Nichols & Katiyar 2010;Katiyar 2011), inhibit UV-induced increased epidermal thickness (Hassan et al 2015), reduce the breakdown of collagen (Song et al 2002;Bae et al 2008;Jackson et al 2010) and regulate skin pigmentation (Lin et al 2008). A 3D human skin model found green tea phenolics to reduce UV-induced cell death via the secretion of interleukin-12 (IL-12), thought to induce DNA repair (Schwarz et al 2008).…”

Section: Green Teamentioning

confidence: 99%

Nutraceuticals and skin appearance: Is there any evidence to support this growing trend?

Spiro

Lockyer

2018

Nutrition Bulletin

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The rise of the nutraceutical market, specifically oral nutrition supplements claiming to improve skin appearance, is striking. This paper aims to examine the published scientific evidence for beneficial effects of nutraceuticals on skin appearance. An overview of skin physiology and intrinsic and extrinsic ageing is provided which underlies the potential physiological processes nutraceuticals purport to counter. Common ingredients used are explored. Some of these (vitamins A, C, B2, B3, B7, copper, iodine, zinc) have authorised skin‐related health claims, but many do not. Current evidence for those without existing authorised claims (e.g. green tea extract, pomegranate extract, carotenoids, evening primrose oil, borage oil, fish oil, collagen and co‐enzyme Q10) is reviewed, focussing primarily on evidence from randomised controlled trials where available, in relation to skin parameters including wrinkles and hydration. Issues of safety are also considered, and the postulated mechanisms for some emerging ingredients, such as cocoa flavanols and probiotics, are explored. Evidence from high quality human trials demonstrating clear benefit is required by regulatory authorities in order for foods and nutrition supplements to carry a health or beauty claim. To date, the evidence for many ingredients in relation to skin appearance is limited, not sufficiently robust and/or inconsistent. Although there are a small number of human studies suggesting a potential benefit and some plausible biological mechanisms, much of the evidence to date comes from animal and in vitro studies. There are simply not enough good quality randomised controlled trials in this area to draw firm conclusions about the benefit of nutraceuticals to skin appearance.

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Role of Green Tea in Reducing Epidermal Thickness upon Ultraviolet Light-B Injury in BALB/c Mice

Cited by 18 publications

References 32 publications

Chemoprotective Effects of Dietary Grape Powder on UVB Radiation-Mediated Skin Carcinogenesis in SKH-1 Hairless Mice

Chemoprotective Effects of Dietary Grape Powder on UVB Radiation-Mediated Skin Carcinogenesis in SKH-1 Hairless Mice

A Study of Food Consumption Patterns in Patients with Gastric Cancer in Mazandaran

Nutraceuticals and skin appearance: Is there any evidence to support this growing trend?

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