Role of growth factors and biomaterials in wound healing

Zarei, Farshad; Soleimaninejad, Maryam

doi:10.1080/21691401.2018.1439836

Cited by 121 publications

(83 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fibroblast growth factors family includes approximately 22 polypeptides that can improve survival, migration, proliferation, differentiation, and metabolic activity of different cells [99]. They are secreted by keratinocytes, fibroblasts, endothelial cells, smooth muscle cells, chondrocytes, and mast cells.…”

Section: Fibroblast Growth Factor-2 (Fgf-2)mentioning

confidence: 99%

See 1 more Smart Citation

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

View full text Add to dashboard Cite

Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

show abstract

Section: Fibroblast Growth Factor-2 (Fgf-2)mentioning

confidence: 99%

“…It also improves epidermal repair and formation of granulation tissue. VEGF is known to promote bone repair, while its absence leads to inhibition of bone regeneration [16,88,91,99,101].…”

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

View full text Add to dashboard Cite

show abstract

“…Other natural sources of astaxanthin include; Zantophyllumiss dendorhousis yeast, Phaffia rhodozyma, and from marine organisms such as Ghezel Alla, Crab and Shrimp [4,5]. Astaxanthin does not elicit side-effects even at higher concentrations, which adds to its significance [6,7]. Researches have failed to report any adverse effects of astaxanthin consumption in humans or animals [5,8,9].…”

Section: Introductionmentioning

confidence: 99%

Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells

Hadipour

Ghoreishi

Baharvand

2019

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

Astaxanthin, a Xanthophyll carotenoid, has strong antioxidant properties. Some studies have shown the effectiveness of this compound on the prevention and treatment of cancer. Therefore, the aim of this study was to evaluate the effects of astaxanthin on induction of apoptosis and antioxidant activity in the LS-180 cell line. In this experimental study, after the treatment of LS-180 50, 100 and 150 lm of Astaxanthin for 24 h, the expression levels of Bax, Bcl2 and Caspase3 genes were investigated by Realtime PCR. Also, the level of malondialdehyde, as an indicator of oxidative stress and activity of antisuperoxide dismutase enzymes, catalase and glutathione peroxidase was investigated by colorimetric methods. The results showed that astaxanthin increases the expression of Bax and Caspase3 genes and decreases that of Bcl2, thereby, inducing apoptosis and inhibiting growth and proliferation of the cells. Additionally, reduction in the levels of malondialdehyde was evident with a significant elevation in antioxidant activity mediated by the action of superoxide dismutase, catalase and glutathione peroxidase. These results suggest that astaxanthin has the potency to induce apoptosis in LS-180 cells by increasing the expression of apoptotic genes and activity of antioxidant enzymes. Thus, astaxanthin has potential in the prevention and treatment of cancer. ARTICLE HISTORY

show abstract

“…Wound healing is a recovery process after defect or disconnect occurs in skin or other related tissues. This process mainly includes the regeneration of various tissue (including epidermis and dermis), the proliferation of granulation tissue and the formation of scar tissue, where diverse synergy effects can be found in this process [123]. At the same time, angiogenesis, inflammation and anti-infection play important roles in wound healing.…”

Section: Wound Healingmentioning

confidence: 99%

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

et al. 2020

View full text Add to dashboard Cite

Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and difficulties in maintaining the drug concentration in the local area. Scaffolds usually are used as implants to supply certain mechanical supporting to the defective area or utilized as diagnosis and imaging methods. But, in general, unmodified scaffolds show limited abilities in promoting tissue regeneration and treating diseases. Therefore, liposome-scaffold composite systems are designed to take advantages of both liposomes' biocompatibility and scaffolds' strength to provide a novel system that is more suitable for clinical applications. This review introduces and discusses different types of liposomes and scaffolds, and also the application of liposome-scaffold composite systems in different diseases, such as cancer, diabetes, skin-related diseases, infection and human immunodeficiency virus, and in tissue regeneration like bone, teeth, spinal cord and wound healing.Journal Pre-proof Drug-loaded liposomesLiposomes have been widely investigated as drug carriers, from the approved amphotericin B liposome in 1990 to the successful Onivyde™ in 2015. As drug carriers, liposomes have several advantages, for instance, they can carry various types of drugs, specifically, the internal water core can load hydrophilic drugs and the bilayers can carry hydrophobic ones. Additionally, liposomes exhibit the ability in controlling the drug release and decreasing the side effect of drugs. Furthermore, liposomes also show advantages in low toxicity, non-immunogenic and biodegradability. The phospholipid bilayer can be regarded as satisfactory platforms that can be modified with diverse ligands to achieve the goal of targeting delivery. Furthermore, the stability and efficacy of biological products can also be improved by utilizing liposomes as vehicles. Delivering small molecule hydrophilic drugsSeveral methods, such as reverse evaporation, pH gradient, ammonium sulfate gradient and repeated freeze thawing, are usually applied in the process of preparing small hydrophilic drugs-loaded liposomes. For example, Takeuchi et al. [14] fabricated polyborane encapsulated liposomes though pH gradient or reverse-phase evaporation, then they found that for the encapsulation efficiency of the liposome Journal Pre-proof 6 prepared using the pH gradient was twice as high as that prepared, using reverse-phase evaporation. Additionally, they observed that boron concentration of the polyborane encapsulated liposomes prepared using the pH gradient achieved 110-150 μg/g of tumor tissue. Delivering small molecule hydrophobic drugsUsually the film dispersion method is one of the simplest ways to fabricate lipid drug-loaded liposomes. For example, Fu et al.[15] fabricated novel temperature-sensitive liposomes loading paclitaxel (PTX-...

show abstract

Role of growth factors and biomaterials in wound healing

Cited by 121 publications

References 59 publications

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Astaxanthin induces apoptosis and increases activity of antioxidant enzymes in LS-180 cells

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

Contact Info

Product

Resources

About