Role of gut–kidney axis in renal diseases and IgA nephropathy

Monteiro, Renato C.; Berthelot, Laureline

doi:10.1097/mog.0000000000000789

Cited by 25 publications

(17 citation statements)

References 83 publications

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“…Intestinal inflammation with associated increased intestinal permeability and modifications to the gut microbiota, are shared pathogenic features between these two conditions. 83 Furthermore, it is unclear whether IgAN associated to IBD van be considered a primary form of IgAN as opposed to secondary IgAN as seen in liver disorders, neoplastic, or inflammatory diseases. Measurement of gd-IgA1 in serum and kidney tissue have been proposed as a potential biomarker that may help establish diagnosis and differentiate between primary and secondary forms of the disease.…”

Section: Igan and Bowel Diseasementioning

confidence: 99%

The Gut and Kidney Crosstalk in Immunoglobulin A Nephropathy

et al. 2022

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Immunoglobulin A nephropathy(IgAN) is the most common primary glomerulonephritis worldwide. The working model for the pathogenesis of IgAN involves a multistep process starting from the production of galactose-deficient and polymeric immunoglobulin A-1 (gd-IgA1) that enters systemic circulation from gut-associated lymphoid tissue (GALT). Galactose-deficient IgA are targeted by endogenous IgG, leading to the formation of circulating immune complexes that deposit in the mesangium and resulting in glomerular inflammation. Disease onset and relapses are often associated with gut infections, supporting the hypothesis that the gut plays an important pathogenic role. In the presence of microbial pathogens or food antigens, activated dendritic cells in the gut mucosa induce T cell dependent and independent B cell differentiation into IgA secreting plasma cells. In IgAN patients, this promotes the systemic release of mucosal gd-IgA1. Not all bacterial strains have the same capacity to elicit IgA production, and little is known about the antigen specificity of the pathogenic gd-IgA1. However, efficacy of treatments targeting gut inflammation support a pathogenic link between the bowel immune system and IgAN. Herein, we review the evidence supporting the role of gut inflammation in IgAN pathogenesis.

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Section: Igan and Bowel Diseasementioning

confidence: 99%

The Gut and Kidney Crosstalk in Immunoglobulin A Nephropathy

et al. 2022

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“…Moreover, enteric corticosteroid; budesonide ameliorated proteinuria in IgAN patients [ 87 , 88 ]. Based on these findings, gut–renal connection in IgAN had been proposed [ 89 , 90 , 91 , 92 ].…”

Section: Galt and Iga Nephropathymentioning

confidence: 99%

Title IgA Nephropathy and Oral Bacterial Species Related to Dental Caries and Periodontitis

Nagasawa

Misaki

Itô

et al. 2022

IJMS

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A relationship between IgA nephropathy (IgAN) and bacterial infection has been suspected. As IgAN is a chronic disease, bacteria that could cause chronic infection in oral areas might be pathogenetic bacteria candidates. Oral bacterial species related to dental caries and periodontitis should be candidates because these bacteria are well known to be pathogenic in chronic dental disease. Recently, several reports have indicated that collagen-binding protein (cnm)-(+) Streptococcs mutans is relate to the incidence of IgAN and the progression of IgAN. Among periodontal bacteria, Treponema denticola, Porphyromonas gingivalis and Campylobacte rectus were found to be related to the incidence of IgAN. These bacteria can cause IgAN-like histological findings in animal models. While the connection between oral bacterial infection, such as infection with S. mutans and periodontal bacteria, and the incidence of IgAN remains unclear, these bacterial infections might cause aberrantly glycosylated IgA1 in nasopharynx-associated lymphoid tissue, which has been reported to cause IgA deposition in mesangial areas in glomeruli, probably through the alteration of microRNAs related to the expression of glycosylation enzymes. The roles of other factors related to the incidence and progression of IgA, such as genes and cigarette smoking, can also be explained from the perspective of the relationship between these factors and oral bacteria. This review summarizes the relationship between IgAN and oral bacteria, such as cnm-(+) S. mutans and periodontal bacteria.

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“…Immunoglobulin A nephropathy (IgAN) is the most common immune-associated primary glomerulonephritis worldwide, characterized by the deposition of IgA, specifically, galactose-deficient IgA1 (Gd-IgA1), in the glomerular mesangium ( Monteiro and Berthelot, 2021 ). Up to 40% of patients ultimately progress to end-stage kidney disease ( Selvaskandan et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiome Characteristics in IgA Nephropathy: Qualitative and Quantitative Analysis from Observational Studies

Han

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundRecent data indicate the importance of gut-kidney axis in the pathogenesis of Immunoglobulin A nephropathy (IgAN). Growing evidence suggests the alterations of diversity and composition of gut microbiome among patients with IgAN, however, the details are not yet fully understood.MethodsEligible studies comparing the gut microbiome between patients with IgAN and non-IgAN individuals were systematically searched from PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, and ClinicalTrials.gov. The primary outcomes were alpha- and beta-diversity, and the differences in gut microbiota composition between patients with IgAN and non-IgAN persons. Qualitative analysis and meta-analysis were performed according to available data.ResultsEleven cross-sectional studies, including 409 patients with IgAN and 243 healthy controls, were enrolled. No significant differences in the diversity and enrichment of gut bacteria were found between IgAN and healthy individuals, whereas the beta-diversity consistently showed significant microbial dissimilarities among the two groups. Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, Fusobacteria, and Verrucomicrobia were the dominant phyla, however, no significant differences were found between IgAN patients and healthy controls at the phylum level. The genera, Streptococcus and Paraprevotella showed a higher proportion in patients with IgAN compared to healthy individuals, whereas Fusicatenibacter showed a lower abundance according to meta-analysis. Qualitative analyses suggested that Escherichia-Shigella might be increased in IgAN patients; the genera, Clostridium, Prevotella 9,and Roseburia, members of Ruminococcaceae and Lachnospiraceae families, were likely to have decreased abundances in patients with IgAN compared to healthy individuals.ConclusionGut microbiota dysbiosis was demonstrated in IgAN, which might be involved in the pathogenesis of IgAN. Further studies are needed to confirm the findings of this study, due to the substantial heterogeneity.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier PROSPERO (CRD42022304034).

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Role of gut–kidney axis in renal diseases and IgA nephropathy

Cited by 25 publications

References 83 publications

The Gut and Kidney Crosstalk in Immunoglobulin A Nephropathy

The Gut and Kidney Crosstalk in Immunoglobulin A Nephropathy

Title IgA Nephropathy and Oral Bacterial Species Related to Dental Caries and Periodontitis

Gut Microbiome Characteristics in IgA Nephropathy: Qualitative and Quantitative Analysis from Observational Studies

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