Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach

Aquino-Martínez, Rubén; Hutchison, Evan; Allayee, Hooman; Lusis, Aldons J.; Rey, Federico E.

doi:10.1016/j.molmet.2022.101557

Cited by 9 publications

(4 citation statements)

References 201 publications

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“…Historically, germ-free mice colonized with microbiota transplant from the obese donors elevated their weight and body fat significantly more than in case of lean donors [ 6 ]. Also, a dozen of microbiota-originated or microbially-modified molecules has been recently acknowledged as factors contributing to metabolic outcome [ 7 ]. Interestingly, the production of these is strictly dependent on obesity status thus the microecological niche as elegantly shown in an in vitro study [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of correlations between gut microbiota, stool short chain fatty acids, calprotectin and cardiometabolic risk factors in postmenopausal women with obesity: a cross-sectional study

et al. 2022

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Background Microbiota and its metabolites are known to regulate host metabolism. In cross-sectional study conducted in postmenopausal women we aimed to assess whether the microbiota, its metabolites and gut barrier integrity marker are correlated with cardiometabolic risk factors and if microbiota is different between obese and non-obese subjects. Methods We analysed the faecal microbiota of 56 obese, postmenopausal women by means of 16S rRNA analysis. Stool short chain fatty acids, calprotectin and anthropometric, physiological and biochemical parameters were correlates to microbiome analyses. Results Alpha-diversity was inversely correlated with lipopolysaccharide (Rho = − 0.43, FDR P (Q) = 0.004). Bray–Curtis distance based RDA revealed that visceral fat and waist circumference had a significant impact on metabolic potential (P = 0.003). Plasma glucose was positively correlated with the Coriobacteriaceae (Rho = 0.48, Q = 0.004) and its higher taxonomic ranks, up to phylum (Actinobacteria, Rho = 0.46, Q = 0.004). At the metabolic level, the strongest correlation was observed for the visceral fat (Q < 0.15), especially with the DENOVOPURINE2-PWY, PWY-841 and PWY0-162 pathways. Bacterial abundance was correlated with SCFAs, thus some microbiota-glucose relationships may be mediated by propionate, as indicated by the significant average causal mediation effect (ACME): Lachnospiraceae (ACME 1.25, 95%CI (0.10, 2.97), Firmicutes (ACME 1.28, 95%CI (0.23, 3.83)) and Tenericutes (ACME − 0.39, 95%CI (− 0.87, − 0.03)). There were significant differences in the distribution of phyla between this study and Qiita database (P < 0.0001). Conclusions Microbiota composition and metabolic potential are associated with some CMRF and fecal SCFAs concentration in obese postmenopausal women. There is no unequivocal relationship between fecal SCFAs and the marker of intestinal barrier integrity and CMRF. Further studies with appropriately matched control groups are warranted to look for causality between SCFAs and CMRF.

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Section: Introductionmentioning

confidence: 99%

Analysis of correlations between gut microbiota, stool short chain fatty acids, calprotectin and cardiometabolic risk factors in postmenopausal women with obesity: a cross-sectional study

et al. 2022

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“…In addition, the intestinal microbiota can participate in host nutrient metabolism by producing a large number of small-molecule metabolites. For example, bacteria from the phyla Bacteroidetes, Firmicutes, Proteobacteria, and Actinobacteria produce short-chain fatty acids, lipopolysaccharides, and peptidoglycans, which not only directly participate in host metabolism but also regulate food intake behavior through the gut-brain-adrenal axis, producing pancreatic glucagon, growth hormone, and ghrelin (30)(31)(32)(33). Firmicutes bacteria can produce carnitine, which activates the formation of brown adipose tissue and beige adipose tissue in the host through the circulation, participating in lipid metabolism (37).…”

Section: Intestine Microorganismsmentioning

confidence: 99%

Research progress on the regulation of production traits by gastrointestinal microbiota in dairy cows

Liu,

Wu,

Guo

et al. 2023

Front. Vet. Sci.

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The composition and abundance of microorganisms in the gastrointestinal tract of cows are complex and extensive, and they play a crucial role in regulating nutrient digestion, absorption, maintaining digestive tract stability, and promoting the production and health of the host. The fermentation carried out by these microorganisms in the gastrointestinal tract is fundamental to the health and productivity of cows. Rumen microorganisms produce the majority of enzymes required to break down feed substrates, such as cellulose, protein, lipids, and other plant materials, through fermentation. This process provides energy metabolism substrates that satisfy approximately 70% of the host’s energy requirements for physiological activities. Gut microorganisms primarily decompose cellulose that is difficult to digest in the rumen, thereby providing heat and energy to the hosts. Additionally, they have an impact on host health and productivity through their role in immune function. Understanding the composition and function of the cow gut microbiota can help regulate dairy cattle breeding traits and improve their health status. As a result, it has become a popular research topic in dairy cattle breeding. This article provides a review of the composition, structure, physiological characteristics, and physiological effects of the cow gut microbiota, serving as a theoretical foundation for future studies that aim to utilize the gut microbiota for dairy cattle breeding or improving production traits. It may also serve as a reference for research on gut microbiota of other ruminants.

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“…Moreover, previous studies have characterized the profile of dysbiotic GM in AF patients [14][15][16][17][18]. The GM contributes to host physiology by producing myriad metabolites that exert their effects within the host as signaling molecules and substrates for metabolic reactions [17,[19][20][21]. For example, short-chain fatty acids (SCFA), including propionate, acetate, and butyrate, during fermentation of the dietary fiber in the colon, are responsible for the energy requirements of the colonic epithelium and its preservation by mitigating chronic inflammatory responses [22].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Sleep Disturbance on Gut Microbiota, Atrial Substrate, and Atrial Fibrillation Inducibility in Mice: A Multi-Omics Analysis

Zuo

Chen

et al. 2022

Metabolites

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This study examined the effect of sleep disturbance on gut microbiota (GM), atrial substrate, and atrial fibrillation (AF) inducibility. C57BL/6 mice were subjected to six weeks of sleep deprivation (SD) using the method of modified multiple-platform. Transesophageal burst pacing was performed to evaluate AF inducibility. Feces, plasma, and an atrium were collected and analyzed by 16s rRNA sequencing, liquid chromatography–mass spectrometry (LC-MS)-based metabolome, histological studies, and transcriptome. Higher AF inducibility (2/30 of control vs. 15/30 of SD, p = 0.001) and longer AF duration (p < 0.001), concomitant with aggravated fibrosis, collagen, and lipid accumulation, were seen in the SD mice compared to control mice. Meanwhile, elevated alpha diversity, higher abundance of Flavonifractor, Ruminococcus, and Alloprevotella, as well as imbalanced functional pathways, were observed in the gut of SD mice. Moreover, the global patterns for the plasma metabolome were altered, e.g., the decreased butanoate metabolism intermediates in SD mice. In addition, disrupted metabolic homeostasis in the SD atrium, such as fatty acid metabolism, was analyzed by the transcriptome. These results demonstrated that the crosstalk between GM and atrial metabolism might be a promising target for SD-mediated AF susceptibility.

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Role of gut microbe-derived metabolites in cardiometabolic diseases: Systems based approach

Cited by 9 publications

References 201 publications

Analysis of correlations between gut microbiota, stool short chain fatty acids, calprotectin and cardiometabolic risk factors in postmenopausal women with obesity: a cross-sectional study

Analysis of correlations between gut microbiota, stool short chain fatty acids, calprotectin and cardiometabolic risk factors in postmenopausal women with obesity: a cross-sectional study

Research progress on the regulation of production traits by gastrointestinal microbiota in dairy cows

The Impact of Sleep Disturbance on Gut Microbiota, Atrial Substrate, and Atrial Fibrillation Inducibility in Mice: A Multi-Omics Analysis

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