Role of HAND2-AS1 in human tumors

Da, Chao-Ming; Cheng, Z.-Y.; Gong, Chang; Wu, Nan; Zhou, Kaisheng; Zhao, Guanghai; Zhang, Haihong

doi:10.1016/j.cca.2020.10.020

Cited by 16 publications

(13 citation statements)

References 52 publications

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“…They believe that it can act as a prognostic marker and therapeutic target for many kinds of tumors. Regulation of HAND2-AS1 in numerous tumor systems can affect the proliferation and other phenotypes of cancer cells, such as osteosarcoma, esophageal squamous cell carcinoma, endometrioid carcinoma, and colorectal cancer [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Identification of novel key regulatory lncRNAs in gastric adenocarcinoma

Razavi

Katanforosh

2022

BMC Genomics

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Background Stomach adenocarcinoma (STAD) is one of the most common and deadly cancers worldwide. Recent evidence has demonstrated that dysregulation of long noncoding RNAs (lncRNA) is associated with different hallmarks of cancer. lncRNAs also were suggested as novel promising biomarkers for cancer diagnosis and prognosis. Despite these previous investigations, the expression pattern, diagnostic role, and hallmark association of lncRNAs in STAD remain unclear. Results In this study, The STAD lncRNA-mRNA network was constructed based on RNAs that differentially expressed among tumor and normal samples and had a strong expression correlation with others. The high degree nodes of the network were associated with overall survival. In addition, we found that the hubs’ regulatory roles have previously been confirmed in different types of cancers by literature. For example, the HCG22 hub inhibited cell proliferation and invasion and induced apoptosis in oral squamous cell carcinoma (OSCC) cells. The levels of PCNA, Vimentin, and Bcl2 were decreased and E-cadherin and Bax expression was elevated in OSCC cells after HCG22 overexpression. Additionally, HCG22 overexpression inhibited the Akt, mTOR, and Wnt/β-catenin pathways. Then lncRNAs were mapped to their related GO terms and cancer hallmarks. Based on these mappings, we predict the hallmarks that might be associated with each lncRNA. Finally, the literature review confirmed our prediction. Among the 20 lncRNAs of the STAD network, 11 lncRNAs (LINC02560, SOX21-AS1, C5orf66-AS1, HCG22, PGM5-AS1, NALT1, ENSG00000241224.2, TINCR, MIR205HG, HNF4A-AS1, ENSG00000262756) demonstrated expression correlation with overall survival (OS). Based on expression analysis, survival analysis, hallmark associations, and literature review, LINC02560, SOX21-AS1, C5orf66-AS1, HCG22, PGM5-AS1, NALT1, ENSG00000241224.2, TINCR, MIR205HG, HNF4A-AS1 plays a regulatory role in STAD. For example, our prediction of association between C5orf66-AS1 expression dysregulation and “sustaining proliferative signal” and “Activating invasion and metastasis” has been confirmed in STAD, OSCC and cervical cancer. Finally, we developed a lncRNA signature with SOX21-AS1 and LINC02560, which classified patients into high and low-risk subgroups with significantly different survival outcomes. The mortality rate of the high-risk patients was significantly higher compared to the low-risk patients (28/1% vs 60.13). Conclusion These findings help in designing more precise and detailed experimental studies to find STAD biomarkers and therapeutic targets.

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Section: Resultsmentioning

confidence: 99%

Identification of novel key regulatory lncRNAs in gastric adenocarcinoma

Razavi

Katanforosh

2022

BMC Genomics

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“…It is closely related to the poor prognosis of patients with lung adenocarcinoma [53]. In gastric cancer, the highly expressed CTD-2510F5.4 may be an independent risk factor for tumors with pathological grade < III and no vascular or nerve in ltration [54]. RP11-324I22.4 is an antisense lncRNA; the gene alias is lnc-CUL2-3.…”

Section: Discussionmentioning

confidence: 99%

Seven Autophagy-Related lncRNAs Associated With Clinical Prognosis in Hepatocellular Carcinoma.

Zhou

Liu

Zhang

et al. 2021

Preprint

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Background: LncRNA may be involved in the occurrence, metastasis, and chemical reaction of hepatocellular carcinoma (HCC) through various pathways associated with autophagy. Therefore, it is urgent to reveal more autophagy-related lncRNAs, explore these lncRNAs' clinical significance, and find new targeted treatment strategies. Methods: In our study, RNA-seq and clinical data of normal and HCC patients were obtained from the TCGA database, and autophagy genes were obtained from the human autophagy database. Results: The risk prediction model containing seven autophagy-related lncRNAs was constructed. Overall survival (OS) curves show that the high-risk group patients significantly shorter than the low-risk group (P=2.292e-10), and the five years survival rate of the high-risk group (HR 0.286, 95%CI 0.199-0.411) is less than half of the low-risk group (HR 0.694, 95%CI 0.547-0.77). Univariate Cox regression indicated that risk score of the risk prediction model (P<0.001, 95%CI 1.210-1.389 ), T (P<0.001, 95%CI 1.443-2.287), and stage (P<0.001 ,95%CI 1.466-2.408 ) were independent prognostic indicators. However, only the risk score remains the independent prognostic indicator(P<0.001, 95%CI 1.197-1.400 ) based on the multivariate analysis. This risk model's prediction efficiency is significantly higher than other clinicopathological factors for 1-, 3- and 5-year survival rate prediction (AUC are 0.853, 0.794, and 0.764, respectively). Remarkably, the 7 autophagy-related lncRNAs may participate in Spliceosome, Cell cycle, RNA transport, DNA replication, and mRNA surveillance pathway and be related to the biological process of RNA splicing and mRNA splicing. Conclusion: In conclusion, the 7 autophagy-related lncRNAs might be promising prognostic and therapeutic targets for HCC.

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“…Heart and neural crest derivatives expressed transcript 2 antisense RNA 1 (HAND2‐AS1) is a lncRNA positioned antisense to the HAND2 genomic loci 228 base pairs upstream of a shared bidirectional promoter region (L. Liu et al, 2023). HAND2‐AS1 is located on human Chromosome 4 and is highly conserved on mouse Chromosome 8 (Da et al, 2020). Previous studies have shown that HAND2‐AS1 dysregulation is associated with many different cancer types (Gong et al, 2020; Shan et al, 2021; X. Yang et al, 2018; You et al, 2018).…”

Section: Heart and Neural Crest Derivatives Expressed Transcript 2 An...mentioning

confidence: 99%

Long noncoding RNAs and their complex role in shaping and regulating arachidonic acid metabolism: Learning to love the (not‐really) junk

Desind,

Bell,

Davidson

et al. 2023

WIREs RNA

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Long noncoding RNAs (lncRNAs) have emerged as critical regulators in numerous biological processes. The arachidonic acid (AA) metabolic pathway is a fundamental biochemical pathway responsible for the enzymatic conversion of AA, a 20‐carbon omega‐six polyunsaturated fatty acid, into a variety of potent lipid signaling molecules known as eicosanoids. Eicosanoids are produced through the cyclooxygenase and lipoxygenase arms of the AA pathway and have diverse biological roles in both healthy and disease states, including cancer and inflammatory diseases. Cyclooxygenase 2 (COX‐2), the inducible, rate‐limiting enzyme of the cyclooxygenase arm, produces two main forms of eicosanoids: prostaglandins and thromboxanes. AA metabolized through the lipoxygenase arm by the action of 5‐lipoxygenase (ALOX5) produces eicosanoids known as leukotrienes. COX‐2 and ALOX5 gene expression are regulated through many different lncRNAs and microRNA (miRNA)‐mediated mechanisms. As previously reviewed, noncoding RNAs affect transcription, splicing, alternative polyadenylation, messenger RNA stability, translation, and miRNA regulation of COX‐2 and ALOX5 (Lutz and Cornett, 2013, Wiley Interdisciplinary Reviews. RNA, 4(5), 593–605). This current review discusses the intricate roles of lncRNAs, including MALAT1, NEAT1, HOTAIR, PACER, and others, in modulating the AA pathway. In this review update, we will delve into advancements in our understanding of AA gene expression regulation. We will explore the mechanisms of lncRNAs and their associated miRNAs and proteins known to regulate key components of the AA signaling pathway. We will also discuss the therapeutic potential of targeting lncRNA‐mediated regulation, with a focus on modulating COX‐2 and ALOX5 activity and downstream eicosanoid production for applications in inflammatory and oncological conditions.This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA in Disease and Development > RNA in Disease

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Role of HAND2-AS1 in human tumors

Cited by 16 publications

References 52 publications

Identification of novel key regulatory lncRNAs in gastric adenocarcinoma

Identification of novel key regulatory lncRNAs in gastric adenocarcinoma

Seven Autophagy-Related lncRNAs Associated With Clinical Prognosis in Hepatocellular Carcinoma.

Long noncoding RNAs and their complex role in shaping and regulating arachidonic acid metabolism: Learning to love the (not‐really) junk

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