Role of Hematological Parameters in Covid-19 Patients in the Emergency Room

Usul, Eren; Şan, İ̇shak; Bekgöz, Burak; Şahin, Ali

doi:10.2217/bmm-2020-0317

Cited by 121 publications

(155 citation statements)

References 21 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…However, it was 1.8 times higher among survivors in our study. This is in stark contrast with the trend observed in a study conducted by Usul et al, wherein NLR was was found to be significantly high in critically ill COVID-19 patients compared to the control population [12]. LMR was also higher in survivors but the association was not statistically significant.…”

Section: Discussioncontrasting

confidence: 93%

Neutrophil-to-Lymphocyte, Lymphocyte-to-Monocyte, and Platelet-to-Lymphocyte Ratios: Prognostic Significance in COVID-19

Bg¹,

Gosavi²,

Rao³

et al. 2021

Cureus

View full text Add to dashboard Cite

Background and objective Neutrophils are primarily responsible for activating the immune system, and systemic inflammation destroys CD4+ T lymphocytes and increases suppressor CD8+ T lymphocytes, thereby leading to an increased neutrophil-to-lymphocyte ratio (NLR). An increase in the apoptosis of lymphocytes leads to lymphopenia and elevated thrombopoietin (THPO) promotes megakaryocyte production. The reflections of these inflammatory changes can be vital in gauging the progression of the disease. This study aimed at examining the prognostic value of normal and derived neutrophil-to-lymphocyte, lymphocyte-to-monocyte, platelet-to-lymphocyte, and mean platelet volume (MPV)-to-platelet count ratios in patients with coronavirus disease 2019 (COVID-19). Methodology This was a retrospective cross-sectional study conducted in the wards of Chigateri General Hospital, Davangere for a period of two months. Complete blood count was ordered for all patients at the time of admission along with confirmation of the disease by reverse transcription-polymerase chain reaction (RT-PCR). Results The final study population consisted of 100 patients. The mean age of patients who survived (43 years) was significantly lower than the mean age of non-survivors (59.1 years), with a p-value of <0.001. NLR was raised in 60% of the population and was significantly higher in patients who survived the disease, with a p-value of 0.004. The platelet-to-lymphocyte ratio (PLR) also followed a similar trend with a p-value of 0.017. Even though the lymphocyte-to-monocyte ratio (LMR) also mimicked the trend, the statistical association was not significant (p-value: 0.09). The derived NLR and MPV-to-platelets ratios were not found to be significantly associated with mortality in this study. Discussion Younger patients had better clinical outcomes in our study population compared to the geriatric age group. A significant correlation between LMR and mortality was observed when a cutoff of 2.5 was considered as a differentiating benchmark. Conflicting trends were observed in NLR and PLR in our study; however, LMR was in accordance with most other studies. The phase that a patient is in with regard to the natural history of the disease also influences the blood cell ratios. Nonetheless, all three ratios can be used as crucial screening and prognostic tools as they are readily available with the help of a complete hemogram. This is an investigation modality that is widely accessible even in remote areas and resource-limited settings. Conclusion These hematological ratios can facilitate in categorizing the disease severity and progression in patients, thereby enabling us to make appropriate and informed clinical decisions. Since the second wave of the novel coronavirus is on the verge of arrival, it is imperative to channel resources for the patients early in their disease course to ultimately prevent complications and reduce mortality.

show abstract

Section: Discussioncontrasting

confidence: 93%

Neutrophil-to-Lymphocyte, Lymphocyte-to-Monocyte, and Platelet-to-Lymphocyte Ratios: Prognostic Significance in COVID-19

Bg¹,

Gosavi²,

Rao³

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…TLC, ANC, ALC, NLR and Platelet counts among the survivors versus non survivors (p<0.05). Similar findings have been reported from a study conducted in Ankara Turkey [9]. Another study from Karachi Pakistan reported 364 Covid-19 patients, with 27.7% mortality.…”

Section: Discussionsupporting

confidence: 89%

Potential Diagnostic and Prognostic Values of Hematological Biomarkers in COVID-19‎ ‎

Khan

2021

Afro-Egyptian Journal of Infectious and Endemic Diseases

View full text Add to dashboard Cite

“…Our finding is in contrast to the overall trend of decreasing platelet count with increasing disease severity, found in the studies from the US, China and Korea [31][32][33][34]. One study from Turkey showed that the platelet count was significantly low in COVID-19 PCR positive cases compared to PCR negative cases [35]. We also learnt that 31.7% (13/41) of the asymptomatic patients had thrombocytopenia at presentation.…”

Section: Discussioncontrasting

confidence: 95%

Characteristics and outcomes of hospitalized adults with COVID-19 in Nepal: a multicenter, prospective cohort study

Chaudhary¹,

Singh

Paudel³

et al. 2020

Preprint

View full text Add to dashboard Cite

Introduction There is limited data on clinical course and outcomes of hospitalized adults with COVID-19 in Nepal. Thus, it is imperative to characterize the features of this disease in the domestic context. Methodology We identified all adult patients with laboratory-confirmed COVID-19 admitted to five different hospitals in Nepal from June 15 to July 15, 2020. We collected epidemiological, socio-cultural and clinicopathologic data, and stratified the patients based on their symptom status. Results The study included 220 patients with an overall median age of 31.5 (25-37) years, and 181 (82.3%) were males. 159 (72.3%) were asymptomatic, and 163 (74.1%) were imported cases. Of 217 patients with the available data, 110 (50.7%) reported their annual household income less than 2000 US dollars, and 122 (56.2%) practiced Pranayama (yogic rhythmic breathing techniques) regularly. Eight patients (3.6%) required supplemental oxygen and two patients (0.9%) died. None of the patients who practiced Pranayama regularly required supplemental oxygen. Compared to asymptomatic patients, symptomatic patients had greater proportion of females (31.1% vs. 12.6%, p=0.001), imported cases (85.2% vs. 69.8%, p=0.02), illiterates (26.8% vs. 12.1%, p=0.01), alcohol users (43.3% vs. 24.5%, p=0.01), patients feeling stigmatized by society (45.8% vs. 22.6%, p=0.001), and had higher platelet count (253 x 10^9/L vs. 185 x10^9/L, p=0.02). Conclusions Most cases were imported, asymptomatic young males, with very few deaths. Pranayama practice was associated with protection against severe COVID-19, but more data is needed to substantiate this. The association of platelets count with symptom status in the Nepalese population needs further exploration.

show abstract

Role of Hematological Parameters in Covid-19 Patients in the Emergency Room

Cited by 121 publications

References 21 publications

Neutrophil-to-Lymphocyte, Lymphocyte-to-Monocyte, and Platelet-to-Lymphocyte Ratios: Prognostic Significance in COVID-19

Neutrophil-to-Lymphocyte, Lymphocyte-to-Monocyte, and Platelet-to-Lymphocyte Ratios: Prognostic Significance in COVID-19

Potential Diagnostic and Prognostic Values of Hematological Biomarkers in COVID-19‎ ‎

Characteristics and outcomes of hospitalized adults with COVID-19 in Nepal: a multicenter, prospective cohort study

Contact Info

Product

Resources

About