Role of heme oxygenase-1 in tumor immune escape

Nitti, Mariapaola; Ortolan, Jasmin; Furfaro, Anna Lisa

doi:10.1530/rem-23-0006

Cited by 4 publications

(2 citation statements)

References 143 publications

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“…Priming signals also activate cellular stress response pathways involving heme oxygenase-1 (HO-1), which was shown to inhibit inflammasome activation ( 19 ). Heme oxygenases responsible for the degradation of heme groups into carbon monoxide, free ferrous iron, and biliverdin, are found in mammals in two different isoforms (HO-1 and HO-2) ( 20 ). The HO-3 isoform has also been described in rat; however, it was found to be encoded by pseudogenes derived from the HO-2 gene, and no functional HO-3 protein has been discovered ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

“…The HO-3 isoform has also been described in rat; however, it was found to be encoded by pseudogenes derived from the HO-2 gene, and no functional HO-3 protein has been discovered ( 21 ). HO-2 is constitutively expressed and found mainly in the brain and testis, whereas HO-1 is a stress-inducible protein that shows a predominantly low level of expression when cells are at the resting stage; however, its expression increases dramatically in the presence of heavy metals, heme, cytokines, hormones, lipid metabolites, and changes in oxygen status ( 20 , 22 ). HO-1 is associated with the smooth endoplasmic reticulum, but is also present in the cell nucleus, mitochondria, and caveolae.…”

Section: Introductionmentioning

confidence: 99%

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Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging

Kaszubowska,

Kaczor,

Karnia

et al. 2024

Front. Immunol.

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IntroductionHeme oxygenase-1 (HO-1) is a stress-inducible heat shock protein (HSP32) that exerts cytoprotective effects against oxidative stress and inflammation, and is involved in the maintenance of cellular homeostasis. This study aimed to evaluate the expression of HO-1 in natural killer (NK) cells from individuals of different age groups after stimulation with various factors, and to analyze the relationships between the concentration of this cytoprotective protein and parameters corresponding to oxidative stress and inflammation, that is, NOD-like receptor protein 3 (NLRP3), glutathione (GSH), GSH disulfide (GSSG), and interleukin 6 (IL-6).MethodsThe study population comprised three age groups: young adults (age range, 19–23 years), older adults aged under 85 years (age range, 73–84 years), and older adults aged over 85 years (age range, 85–92 years). NLRP3, GSH, and GSSG concentrations were measured in serum, whereas the HO-1 concentration and IL-6 expression were studied in NK cells cultivated for 48 h and stimulated with IL-2, lipopolysaccharide (LPS), or phorbol 12-myristate 13-acetate (PMA) with ionomycin.ResultsThe analysis of serum NLRP3, GSH, and GSSG concentrations revealed no statistically significant differences among the studied age groups. However, some typical trends of aging were observed, such as a decrease in GSH concentration and an increase in both GSSG level, and GSSG/GSH ratio. The highest basal expression of IL-6 and lowest basal content of HO-1 were found in NK cells of adults over 85 years of age. The NK cells in this age group also showed the highest sensitivity to stimulation with the applied factors. Moreover, statistically significant negative correlations were observed between HO-1 and IL-6 expression levels in the studied NK cells.ConclusionsThese results showed that NK cells can express HO-1 at a basal level, which was significantly increased in activated cells, even in the oldest group of adults. The reciprocal relationship between HO-1 and IL-6 expression suggests a negative feedback loop between these parameters.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging

Kaszubowska,

Kaczor,

Karnia

et al. 2024

Front. Immunol.

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Navigating heme pathways: the breach of heme oxygenase and hemin in breast cancer

Consoli,

Sorrenti,

Gulisano

et al. 2024

Mol Cell Biochem

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Breast cancer remains a significant global health challenge, with diverse subtypes and complex molecular mechanisms underlying its development and progression. This review comprehensively examines recent advances in breast cancer research, with a focus on classification, molecular pathways, and the role of heme oxygenases (HO), heme metabolism implications, and therapeutic innovations. The classification of breast cancer subtypes based on molecular profiling has significantly improved diagnosis and treatment strategies, allowing for tailored approaches to patient care. Molecular studies have elucidated key signaling pathways and biomarkers implicated in breast cancer pathogenesis, shedding light on potential targets for therapeutic intervention. Notably, emerging evidence suggests a critical role for heme oxygenases, particularly HO-1, in breast cancer progression and therapeutic resistance, highlighting the importance of understanding heme metabolism in cancer biology. Furthermore, this review highlights recent advances in breast cancer therapy, including targeted therapies, immunotherapy, and novel drug delivery systems. Understanding the complex interplay between breast cancer subtypes, molecular pathways, and innovative therapeutic approaches is essential for improving patient outcomes and developing more effective treatment strategies in the fight against breast cancer.

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Copper complexes induce haem oxygenase-1 (HMOX1) and cause apoptotic cell death in pancreatic cancer cells

Jhetam,

Martins-Furness,

Slabber

et al. 2024

Journal of Inorganic Biochemistry

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Role of heme oxygenase-1 in tumor immune escape

Cited by 4 publications

References 143 publications

Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging

Expression of a stress-inducible heme oxygenase-1 in NK cells is maintained in the process of human aging

Navigating heme pathways: the breach of heme oxygenase and hemin in breast cancer

Copper complexes induce haem oxygenase-1 (HMOX1) and cause apoptotic cell death in pancreatic cancer cells

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