Role of heparin and tissue type plasminogen activator in high altitude adaptation of the hemostasis system

The Mast cell system and blood coagulation in mountain dogs with myocardial infarction

“…That the state of the coagulation system is dependent upon that of the MC system under highaltitude conditions is conffLrmed by the study of Bashkov et al [3], who found that variations in the blood level of heparin depend on the extent to which MC are saturated with heparin and on the degree of their metachromasia and degranulation.…”

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A comparative study of the responses of the mast cell and coagulation systems to experimentally induced myocardial infarction in dogs that had been constantly hying at a medium altitude (1600 m above sea level) and those constantly hying at a low altitude (760 m) revealed less marked morphological and functional changes in these systems in the former ("mountain") dogs, which may be interpreted as an indication of their enhanced nonspecific resistance acquired as a result of long-term adaptation to conditions prevailing at medium altitudes.Studies in which the impact of various extremely adverse factors on the mast cell and coagulation systems was examined, have demonstrated that a relationship exists between the state of mast cells (MC) and alterations in the coagulation system [3,[9][10][11]. This prompted us to investigate the state and role of MC in pathological conditions involving coagulation disorders, given that MC are known Laboratory for the Study of Respiration and Blood Circulation, Institute of Physiology and Experimental Pathology at High Altitudes, Academy of Sciences of the Kyrgy'z Republic, Bishkek.

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“…Studies in which the impact of various extremely adverse factors on the mast cell and coagulation systems was examined, have demonstrated that a relationship exists between the state of mast cells (MC) and alterations in the coagulation system [3,[9][10][11]. This prompted us to investigate the state and role of MC in pathological conditions involving coagulation disorders, given that MC are known Laboratory for the Study of Respiration and Blood Circulation, Institute of Physiology and Experimental Pathology at High Altitudes, Academy of Sciences of the Kyrgy'z Republic, Bishkek.…”