Role of Hepatocyte Growth Factor and c-Met Receptor in Neoplastic Conditions of Salivary Glands

Tsukinoki, Keiichi; Yasuda, Masanori; Miyoshi, Yoshiko; Mori, Yusuke; Otsuru, Mitsunobu; Saruta, Juri; Sato, Sadao; Kaneko, Akihiro; Watanabe, Yoshihisa; Osamura, R. Yoshiyuki

doi:10.1267/ahc.38.25

Cited by 10 publications

(10 citation statements)

References 34 publications

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“…The protective role of musk on salivary glands of mice exposed to chronic unpredictable mild stress Nasra N. Ayuob 1,2) , Hanem S. Abdel-Tawab 3) , Ahmed A. El-Mansy 2,4) , and Soad S. Ali 1,5,6) activation of the hypothalamic-pituitary-adrenal (HPA) axis and decreased levels of brain-derived neurotrophic factor (BDNF), which can be reversed by antidepressant drugs (4). It has been reported that the salivary glands are affected by both acute and chronic stress.…”

Section: Originalmentioning

confidence: 99%

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The protective role of musk on salivary glands of mice exposed to chronic unpredictable mild stress

et al. 2019

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This study assessed the impact of chronic unpredictable mild stress (CUMS) on the structure of mouse salivary glands and the role of musk in alleviating this impact. Forty male albino mice were distributed equally into four groups; control (untreated), CUMS (exposed to CUMS for 4 weeks), CUMS+fluoxetine (FLU) (exposed to CUMS then treated with FLU, CUMS+musk (exposed to CUMS then treated with musk). Behavioral changes and serum corticosterone levels were assessed at the end of the experiment. The submandibular and parotid glands were dissected out and processed for histopathological and immunohistochemical examination using antibodies against alpha smooth muscle actin (ASMA) and brain-derived neurotropic factor (BDNF). Exposure to CUMS significantly (P < 0.001) increased the serum corticosterone level and induced depression. CUMS also induced vacuolation in acinar cells along with a significant (P < 0.001) reduction of ASMA immunoexpression, indicating an effect on myoepithelial cells, and a significant (P < 0.001) increase of BDNF expression in the gland ductal system. Both FLU and musk alleviated the CUMS-induced behavioral, biochemical and histopathological changes in the salivary glands. In conclusion, musk ameliorates stress-induced structural changes in mouse salivary glands. This effect might be mediated through up-regulation of BDNF secretion by the glands.

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Section: Originalmentioning

confidence: 99%

“…The salivary glands play an important role in both oral and systemic health, secreting saliva and a number of biologically active substances such as nerve growth factor (NGF), produced specifically by the submandibular glands (SMGs) (1).…”

Section: Introductionmentioning

confidence: 99%

The protective role of musk on salivary glands of mice exposed to chronic unpredictable mild stress

et al. 2019

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“…Mouse salivary gland tissue expresses a high level of NGF (Cohen 1960(Cohen ,1962, which is massively released from salivary glands into the bloodstream during fighting (Aloe et al 1986;De Simone et al 1990), and plasma EGF level is reduced after damage to the major salivary glands (Hwang et al 1991). Hence, the salivary glands may play an important role in systemic health (Tsukinoki et al 2005). …”

Section: Introductionmentioning

confidence: 99%

Chronic stress affects the expression of brain-derived neurotrophic factor in rat salivary glands

Saruta

Lee

Shirasu

et al. 2010

Stress

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Plasma brain-derived neurotrophic factor (BDNF) levels are associated with several neural disorders. Previously, we reported that BDNF is produced from salivary glands under acute immobilization stress. Additionally, salivary glands are the origin of plasma BDNF during stress; however, the association between the expression of BDNF by the salivary glands under chronic stress conditions is not known. In the present study, we investigated whether plasma BDNF levels in chronic stress depend on the salivary glands. Expression of BDNF mRNA and protein were identified in the submandibular glands when male rats were exposed to chronic restraint stress (12 h daily for 22 days). Chronic stress significantly increased plasma BDNF concentration, as well as adrenocorticotropic hormone and corticosterone levels, but was not altered under chronic stress in bilaterally sialoadenectomized rats. Since chronic stress increases plasma BDNF levels in the sialoadenectomized rat model, the plasma BDNF level was not dependent on BDNF from the salivary glands. Although the salivary glands were the source of plasma BDNF in acute stress conditions in our previous study, it seems that that the increased BDNF expression in the salivary glands in chronic stress does not contribute importantly to the increased circulating BDNF level. The increased plasma BDNF levels may play important roles in homeostasis under stress conditions.

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“…Salivary glands produce several cell growth factors and play an important role in human health [7]. Accordingly, the discovery that growth factors such as epidermal growth factor (EGF) and nerve growth factor (NGF) in the rat submandibular gland led to the acknowledgment of new salivary gland functions [8,9].…”

Section: Introductionmentioning

confidence: 99%

Brain-derived neurotrophic factor is related to stress and chewing in saliva and salivary glands

Saruta

Sakaguchi

et al. 2020

Japanese Dental Science Review

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SummaryChewing is one of the most important orofacial functions. During this process, food is reduced in size, while saliva moistens the food and binds it into a bolus that can be easily swallowed. Characteristics of the oral system, including the number of teeth, bite force, and salivary flow, influence the masticatory process. In addition, salivary glands produce several cell growth factors and play an important role in human health. The nerve growth factor (NGF) family consists of NGF, brain-derived neurotrophic factor (BDNF), and neurotrophins-3 to 7. BDNF is a well-studied neurotrophin involved in the neurogenesis, differentiation, and maintenance of select peripheral and central neuronal cell populations during development and adulthood. However, there has been no detailed description of the expression of neurotrophins other than NGF in the salivary gland. We previously studied the effect of immobilization stress + chewing on BDNF secretion and its receptor, tyrosine receptor kinase B, in rat submandibular glands and found increased BDNF expression in duct cells under these conditions. In this review, we describe recent advances in understanding the role of stress and chewing-related BDNF in the saliva and salivary glands.

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Role of Hepatocyte Growth Factor and c-Met Receptor in Neoplastic Conditions of Salivary Glands

Cited by 10 publications

References 34 publications

The protective role of musk on salivary glands of mice exposed to chronic unpredictable mild stress

The protective role of musk on salivary glands of mice exposed to chronic unpredictable mild stress

Chronic stress affects the expression of brain-derived neurotrophic factor in rat salivary glands

Brain-derived neurotrophic factor is related to stress and chewing in saliva and salivary glands

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