Role of Herbal Active Compound in Cardiac Failure Treatment

The main objective of this research was to create and evaluate the efficacy of orally disintegrating tablets containing sumatriptan succinate at a dosage of 25 milligrammes, a medicine commonly prescribed for the treatment of migraines. The tablets are made using the direct compression method. In order to achieve best results, the formulations were enriched with microcrystalline cellulose of varying composition (Avicel PH 102), mannitol as a diluent, crospovidone, croscaramellose, and sodium starch glycollate as superdisintegrants. Carbomer (carbopol 940), Sodium CMC, and Sodium Alginate were among the other excipients that were used. When used at varying doses, these excipients act as disintegrants. In addition, magnesium stearate was used as a substance to reduce friction, while talc was used as a substance to improve flow. We assessed each of the excipients to ascertain their compatibility with the model drug. The findings revealed no occurrence of any physical or chemical interaction. Before compression, the preformulation features of the tablet blend were examined. The criteria considered were bulk density, tapped density, compressibility index, and hausner ratio. An assessment was carried out on central tablets to ascertain their dimensions, firmness, tendency to crumble, variability in weight, rate of disintegration, and uniformity of drug content properties. Furthermore, an investigation was conducted to examine the impact of these variables on the release of the drug. The drug release studies were performed in vitro using the USP dissolving apparatus-II (paddle type) with a phosphate buffer solution at a pH of 6.8. The experiments were conducted at a speed of 50 revolutions per minute at a temperature of 37 degrees Celsius, with a standard deviation of 5 degrees Celsius. The sampling was conducted at consistent intervals of 2, 4, 6, 8, and 10 minutes. After each withdrawal, an equivalent volume of dissolving medium was replaced with the sample. The ultraviolet (UV) method is employed to evaluate the cumulative quantity of medications that have been discharged at different time intervals. Based on the evaluation results, the F-3 trial formulation, which included 6% crospovidone, was selected as the superior formulation among the superdisintegrants. Conversely, the F-10 trial formulation, which included 2% carbopol 940p, was selected as the superior formulation compared to other basic disintegrants.

Design Formulation and Evaluation of Anti Migraine Mouth Dissolving Tablets Using Different Super Disintegrants

Kumar,

Loveleen,

Passi

et al. 2024

A Comparative Study of In Vitro Antibacterial Activity Capacity of Leaf Extract of Zanthoxylum armatum (Timur)

Lunthi,

Saini,

Patil

2024

Zanthoxylum armatum also known as Timru and toothache tree. This is a sub deciduous aromatic, branched, scandent, or erect shrub or a small tree that grows to 6–7 meter in height and belongs to the Rutaceous family. This plant is common in the hot valleys of the Himalayas from Jammu to Bhutan, Nepal, and Pakistan. It covers a considerable portion of Orissa and Andhra Pradesh in India This plant is considered as a divine plant in contiguous areas. The seeds contain many important phytoconstituents and essential oils which contribute to its biological activities including larvicidal, anti-inflammatory, analgesic, antinociceptive, antioxidant, antibiotic, hepatoprotective, antiplasmodial, cytotoxic, antiproliferative, anthelmintic, antiviral and antifungal. It contains alkaloids, essential oil, resins, sterols, triterpenes, glycosides, saponins, tannins and flavonoids. Because of its Significant medicinal properties and excessive increase in demand has put this plant in the category of endangered plants. This research paper focuses on the Antibacterial activity of the zanthoxylum armatum plant.

Qualitative Investigation and Screening of Antimicrobial Activity of Stem Extract of Clerodendrum Infortunatum Plant

Singh,

Saini,

Patil

2024

Clerodendrum infortunatum is also known as hill glory bower. Clerodendrum infortunatum plants are widely distributed throughout the whole world. Up to now, many species of C. infortunatum have been described in various indigenous systems of medicine that are used in preparation of folklore medicines for the treatment of various life-threatening disease, and more of the Clerodendrum infortunatum have been very well studied for their chemical constituents and biological activities It also used in Unani, Ayurveda, and siddha system of medicine for many years. In the Clerodendrum Infortunatum many compounds, including monoterpentine and its derivatives, sesquiterpene, di-terpenoids, tri-terpentine, flavonoid, quercetin, acacetin, gallic acid, sterols and flavonoid glycoside, phenylethanoid glycoside, steroids and steroid glycosides, cyclohexylethanoids, anthraqunine, cyanogenic glycosides, and others have been isolated and identified. In the present study, Chloroform, pet.ether, and water stem extract Clerodendrum infortunatum obtained by Soxhlet extraction was screened to detect the presence or absence of several bioactive compounds which are reported to cure different diseases. Anti-microbial analysis of stem extract was carried out against lacto-bacillus, E.coli and staphylococcus aureus organisms by agar well diffusion method.It was observed that the zone was recorded against this organism. The results indicates that the chloroform, pet.ether and water extract of C. infortunatum is having anti- microbial efficiency in controlling the microorganisms. So, clerodendrum infortunatum is the plant which are benificial on human health.