Role of high sensitivity C-reactive protein and other risk factors in intracranial and extracranial artery occlusion in patients with ischaemic stroke

Abstract

Objective: A retrospective case-control study to identify stroke-associated risk factors and quantify serum C-reactive protein in patients with ischaemic stroke, with or without intracranial and/or extracranial artery occlusion (IEAO). Methods: Patients with ischaemic stroke and internal carotid artery occlusion (ICAO), middle cerebral artery occlusion (MCAO), ICAO þ MCAO, or no IEAO (control patients) were retrospectively recruited. Data regarding stroke-associated risk factors were retrieved from medical records. High sensitivity (hs)-CRP was quantified within 3 days of hospital admission. Results: Patients with ICAO (n ¼ 89), MCAO (n ¼ 74) and ICAO þ MCAO (n ¼ 29) had significantly higher serum hs-CRP concentrations, and were significantly more likely to have coronary heart disease, a history of stroke, and more than three stroke-associated risk factors than control patients (n ¼ 84). Conclusions: Coronary heart disease and a history of stroke are risk factors for ischaemic stroke with IEAO. Hs-CRP may be used as a marker for IEAO.

Plasma Fibroblast Growth Factor 23 Concentration Is Associated with Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients

“…30 C-reactive protein is a sensitive indicator of vascular inflammation and a marker of cerebral atherosclerosis. 31 In line with these previous results, the present study found that the plasma FGF23 concentration was positively correlated with that of C-reactive protein, with the latter also being higher in patients with accompanying ICAS than in those without cerebral atherosclerosis. Second, FGF23 is a phosphaturic hormone produced mainly by osteoblasts and osteocytes, and is implicated in blood calcium and phosphate concentrations, the vitamin D pathway, and ectopic site mineralization.…”

Prognostication of Incidence and Severity of Ischemic Stroke in Hot Dry Climate From Environmental and Non-Environmental Predictors

“…This matches the results of other studies [87]- [89]. 2) Laboratory markers of stroke severity C-reactive protein (CRP) is a known marker of an early diagnosis of stroke, its recurrence and severity [90], [91].…”

High-sensitivity C-reactive protein in stroke patients – The importance in consideration of influence of multiple factors in the predictability for disease severity and death

“…Therefore, identification of biomarkers for atherosclerosis-artery stenosis or occlusion is essential for the early prevention of stroke. Considerable studies have already shown that an elevated serum CRP level reflects an increased tendency for plaque rupture and a high atherosclerotic burden [13,32,33,[40][41][42].…”

“…Although many inflammatory biomarkers have been reported to be useful in predicting clinical outcome after stroke, hsCRP remains one of the most widely used in clinical practice [8][9][10][11][12]. Increased hsCRP has been associated with the development of atherosclerosis, ischaemic attacks, hemorrhagic stroke, as well as disease outcomes [13][14][15][16][17]. Studies suggest that post-stroke inflammatory responses may exacerbate tissue damage after cerebral infarction and affect clinical outcomes [18,19].…”