Role of high-sensitivity C-reactive protein (hs-CRP) in assessment of asthma control in children

Kumar, Arvind; Jat, Kana Ram; Sankar, Jhuma; Lakshmy, R.; Lodha, Rakesh; Kabra, S. K.

doi:10.1080/02770903.2022.2155187

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…In adult patients, the CRP level decreased signi cantly in well-controlled asthma compared with poorly controlled (24). In asthmatic children, high CRP group had higher proportion of uncontrolled asthma (25), which furtherly suggested that circulating CRP level could re ect the effect for asthma treatment. To sum up, these observational researches have demonstrated that serum CRP was increased in asthma and might predict the risk and prognosis for asthmatic patients.…”

Section: Discussionmentioning

confidence: 85%

The causality between C-reactive protein and asthma: a two-sample Mendelian randomization analysis

Mou,

Cao,

Wang

et al. 2024

Postgraduate Medical Journal

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Purpose This study sought to investigate the causal effects of circulating C-reactive protein (CRP) level on risk of asthma and its subtypes by two-sample Mendelian randomization (MR) analysis. Methods We utilized single nucleotide polymorphisms (SNPs) associated with both CRP and outcomes of asthma, allergic asthma, and obesity-related asthma as genetic variables via a genome-wide summary association study (GWAS). MR analysis mainly based on the inverse variance weighted (IVW) method was performed to infer the causal relationship between exposure and outcomes. Cochran’s Q test and MR-Egger regression analysis were performed to determine respectively the heterogeneity and pleiotropy among instrumental variables (IVs), and leave-one-out analysis was conducted to determine the stability of the MR results. Results In our study, 42 SNPs were identified as IVs for MR analyses. According to the primary inference results by IVW methods, circulating CRP was demonstrated to be significantly associated with risk of asthma [odds ratio (OR): 1.046; 95% confidence interval (95% CI): 1.004–1.090; P = .030] and obesity-related asthma (OR: 1.072; 95% CI: 1.009–1.138; P = 0.025), whereas no distinct causality with allergic asthma was found (OR: 1.051; 95% CI: 0.994–1.112; P = .081). Sensitivity analyses indicated that there was no horizontal pleiotropy among IVs, and the MR results were proved to be robust by leave-one-out sensitivity analysis, despite the presence of heterogeneity. Conclusion The present study suggested that higher CRP might genetically predict an increased risk of developing asthma and obesity-related asthma, without causality with allergic asthma.

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Section: Discussionmentioning

confidence: 85%

The causality between C-reactive protein and asthma: a two-sample Mendelian randomization analysis

Mou,

Cao,

Wang

et al. 2024

Postgraduate Medical Journal

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“…With comorbid depression and asthma, there is an increase in inflammatory markers. One such marker is C-reactive protein (CRP), a potential biomarker of asthma control ( 34 ). CRP has been found to be elevated in children and adolescents with comorbid asthma and depression ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Depressive symptoms are related to asthma control but not self-management among rural adolescents

Patel,

Céspedes,

Liu

et al. 2024

Front. Allergy

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BackgroundDepression, a relevant comorbidity with asthma, has been reported to be associated with asthma morbidity. Asthma self-management is essential to asthma control and may be negatively impacted by depression. We examined these associations in rural adolescents, a group with relatively high asthma morbidity and depressive symptoms, a population often ignored in asthma research.MethodsWe used baseline data from a randomized trial of an asthma intervention for adolescents in rural South Carolina (n = 197). Adolescents completed the Center for Epidemiological Studies-Depression (CES-D), three indices of asthma self-management (the Asthma Prevention Index, the Asthma Management Index and the Asthma Self-Efficacy Index), and the Asthma Control Test (ACT). Poisson and linear regression tested associations between depression, self-management, and asthma control. The models controlled for demographic variables and included school as a fixed effect.ResultsMost participants (mean age = 16.3 ± 1.2 years) self-identified as female (68.5%) and Black (62.43%). The mean CES-D score was 19.7 ± 10.3, with 61.4% of participants at risk for depression. The depressive symptoms were significantly related to asthma control [β = −0.085, 95% confidence interval (CI) = −0.14 to −0.03] but not to prevention [relative risk (RR) = 1.00, 95% CI = 0.99–1.01], management (RR = 1.00, 95% CI = 0.99–1.01), or self-efficacy (β = −0.002, 95% CI = −0.01 to 0.01),ConclusionsIn this sample of rural adolescents, as depressive symptoms increased, asthma control declined. Depressive symptoms were not associated with asthma self-management, suggesting that the aspects of self-management we assessed are not an avenue by which depression impacts asthma control. Additional research is needed to further understand the relationship between depressive symptoms, asthma self-management, and control.

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“…Elevated hs-CRP has been shown in early-onset diseases and has been associated with an increased prevalence of overweight and obesity in children [8,9]. Further, studies have shown that elevated hs-CRP is a biomarker of childhood asthma [10] and allergy [11] but is also associated with Attention deficit hyperactivity disorder (ADHD) development [12]. Hence, hs-CRP is a valuable tool for understanding childhood obesity risk, asthma, allergy, and overall health status.…”

Section: Hs-crp As a Target For Physiological Conditionsmentioning

confidence: 99%

A Chemical Structure and Machine Learning Approach to Assess the Potential Bioactivity of Endogenous Metabolites and Their Association with Early Childhood Systemic Inflammation

Lovrić,

Wang,

Staffe

et al. 2024

Metabolites

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Metabolomics has gained much attention due to its potential to reveal molecular disease mechanisms and present viable biomarkers. This work uses a panel of untargeted serum metabolomes from 602 children from the COPSAC2010 mother–child cohort. The annotated part of the metabolome consists of 517 chemical compounds curated using automated procedures. We created a filtering method for the quantified metabolites using predicted quantitative structure–bioactivity relationships for the Tox21 database on nuclear receptors and stress response in cell lines. The metabolites measured in the children’s serums are predicted to affect specific targeted models, known for their significance in inflammation, immune function, and health outcomes. The targets from Tox21 have been used as targets with quantitative structure–activity relationships (QSARs). They were trained for ~7000 structures, saved as models, and then applied to the annotated metabolites to predict their potential bioactivities. The models were selected based on strict accuracy criteria surpassing random effects. After application, 52 metabolites showed potential bioactivity based on structural similarity with known active compounds from the Tox21 set. The filtered compounds were subsequently used and weighted by their bioactive potential to show an association with early childhood hs-CRP levels at six months in a linear model supporting a physiological adverse effect on systemic low-grade inflammation.

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Role of high-sensitivity C-reactive protein (hs-CRP) in assessment of asthma control in children

Cited by 7 publications

References 24 publications

The causality between C-reactive protein and asthma: a two-sample Mendelian randomization analysis

The causality between C-reactive protein and asthma: a two-sample Mendelian randomization analysis

Depressive symptoms are related to asthma control but not self-management among rural adolescents

A Chemical Structure and Machine Learning Approach to Assess the Potential Bioactivity of Endogenous Metabolites and Their Association with Early Childhood Systemic Inflammation

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