Role of High-Sensitivity C-reactive Protein (Hs-CRP) in Non-communicable Diseases: A Review

Banait, Tanvi; Wanjari, Anil; Danade, Vedika; Jain, Jyoti

doi:10.7759/cureus.30225

Cited by 37 publications

(36 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that CRP can promote atherosclerosis, blood stagnation, and plaque formation. TH can lead to blood hyperviscosity syndrome, so the increase in CRP may be related to this reason ( 32 , 33 ). According to the brain MR results and the elevated CRP in both groups in our research, we believe that the heavier the HIE, the higher the risk of hs-CRP elevation after mild hypothermia treatment.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic hypothermia can cause non-infective C-reactive protein elevating

et al. 2023

View full text Add to dashboard Cite

ObjectiveTo analyze the relationship between therapeutic hypothermia (TH) and whole blood high-sensitivity C-reactive protein (hs-CRP) in neonates with hypoxic-ischemic encephalopathy (HIE).MethodRetrospective analysis was made on the clinical data of hospitalized infants diagnosed with asphyxia in our neonatal intensive care unit from January 2014 to June 2021. According to whether TH was performed, they were divided into two groups, the control group (missed the time in other hospitals and did not receive TH) and the treatment group (TH group). In their first ten days, analysis was made on the hs-CRP, white blood cell (WBC) count, neutrophil percentage, platelet count (PLT), and brain MRI. The correlation analysis was carried out based on the severity of brain injury displayed by the brain MRI and the time of hs-CRP elevation to summarize the relationship between TH and the time of hs-CRP elevation and the severity of HIE.Results83 infants were included, 28 in the control group and 55 in the TH group. After birth, 33 infants (60.0%) in the TH group and 2 patients (7.1%) in the control group had elevated hs-CRP, which was statistically significant (P < 0.05). The time window for CRP elevation after TH was 72–96 h after the end of treatment; The results of the brain MRI showed 23 in the TH group and 11in the control group with moderate and severe HIE. 21 infants (all in the TH group) had elevated hs-CRP. MRI showed that the number of infants with mild injury or regular infants whose hs-CRP raised in the TH group was 12, and the rate of hs-CRP elevation was 37.5%; in the control group, the rate was 11.8%. The difference was significant. TH can decrease PLT and WBC, but no significance in the two groups. Blood and sputum cultures were negative in all infants, and there were no signs of infection.ConclusionsTH can increase the blood hs-CRP of HIE neonates, and the probability of its occurrence is related to the severity of HIE. The heavier the HIE, the higher the risk of hs-CRP elevation after TH; The hs-CRP elevation has little to do with infection, and it doesn't recommend using antibiotics actively.

show abstract

Section: Discussionmentioning

confidence: 99%

Therapeutic hypothermia can cause non-infective C-reactive protein elevating

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Restriction of sleep reduces insulin sensitivity the next day by increasing cortisol levels in the nighttime ( 45 , 46 ). In contrast, some infection markers such as IL-6, and C-reactive protein increase in people who report prolonged sleep, which accelerates the progression of diabetes and its complications ( 47 , 48 ). Therefore, based on the results we obtained; it can be considered sleep duration/quality as a risk marker in monitoring diabetes.…”

Section: Discussionmentioning

confidence: 99%

Demographic variables, anthropometric indices, sleep quality, Metabolic Equivalent Task (MET), and developing diabetes in the southwest of Iran

Hosseini

Beiranvand

Zarea

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

ProposeThe present study has sought to investigate the prevalence of diabetes and its related risk factors, to examine the relationship between demographic variables, anthropometric indices, sleep quality, and Metabolic Equivalent Task (MET) with diabetes in Khuzestan province, southwest Iran.MethodsThe present study has a cross-sectional design (the baseline data of the Hoveyzeh cohort study as a sub-branch of the Persian Prospective Cohort Study). Comprehensive information from 10,009 adults (aged 35–70 years) was collected from May 2016 to August 2018 through a multi-part general questionnaire containing general characteristics, marital status, education, smoking, sleep quality, MET, and anthropometric indices. Data analysis was performed by SPSS software version 19.ResultsThe mean age of the sample was 52.97 ± 8.99 years. 60.3% of the population were women and 67.7% were illiterate. Out of the 10,009 people surveyed, 1,733 stated that they have diabetes (17%). In 1,711 patients (17%) the amount of FBS was ≥126 mg/dl. There is a statistically significant relationship between diabetes and MET. More than 40% had BMI above 30. Anthropometric indices in diabetic and non-diabetic individuals were different. Also, there was a statistically significant difference between the mean duration of sleep and the use of sleeping pills in diabetic and non-diabetic groups (p < 0.05). Based on logistic regression, marital status [OR = 1.69 (95% CI, 1.24, 2.30)], education level [OR = 1.49 (95% CI, 1.22, 1.83)], MET [OR = 2.30 (95% CI, 2.01, 2.63)], height [OR = 0.99 (95% CI, 0.98, 0.99)], weight [OR = 1.007 (95% CI, 1.006, 1.012)], wrist circumference [OR = 1.10 (95% CI, 1.06, 1.14)], waist circumference [OR = 1.03 (95% CI, 1.02, 1.03)], waist-to-hip ratio [OR = 3.41 (95% CI, 2.70, 4.29)], and BMI [OR = 2.55 (95% CI, 1.53, 4.25)], are good predictors for diabetes.ConclusionThe results of this study showed that the prevalence of diabetes in Hoveyzeh city, Khuzestan, Iran, was almost high. and emphasize that preventive interventions should focus on risk factors, especially socioeconomic status, and anthropometric indicators along with lifestyle.

show abstract

“…The median of hsCRP of 1.26 µg mL −1 in women and 1.05 µg mL −1 in men fall in the range of 1–2 µg mL −1 which were associated with a higher risk for cardiovascular disease. [ 33 ] All data were shown as mean and standard deviation (SD) or standard error of mean (SEM) in tables and graphs. Statistical significance was assumed at p < 0.05.…”

Section: Methodsmentioning

confidence: 99%

Effects of a Short‐Term Vegan Challenge in Older Adults on Metabolic and Inflammatory Parameters—A Randomized Controlled Crossover Study

Döschner,

Schulze,

Göger

et al. 2024

Molecular Nutrition Food Res

View full text Add to dashboard Cite

ScopeA long‐term vegan diet carries the risk of insufficient protein and micronutrient intake for older adults. However, even a short‐term (48 h) vegan diet exerts positive metabolic effects in younger adults. In this study, we investigate the feasibility and effects of a short‐term vegan challenge on metabolic and inflammatory markers in older adults.Method and resultsIn this randomized controlled crossover‐study, 30 healthy older adults (≥65 years) are assigned to either a 48 h ad libitum vegan or omnivorous diet. During the vegan diet, participants exhibit lower protein (p = 0.001) and fat intake as well as higher carbohydrate and dietary fiber intake, resulting in a lower caloric intake (all p < 0.001). Insulin concentrations (p = 0.042) and insulin resistance (p = 0.036) decline only after the vegan diet. The study observes reductions in serum glucose (p < 0.001), triglyceride (p = 0.005), and hsCRP (p = 0.044) concentrations and weight (p < 0.001), independent of the diet. Participants with low‐grade inflammation exhibit notable metabolic improvements after the vegan diet.ConclusionImprovements in insulin homeostasis are observed after the vegan diet, but meeting protein requirements are not feasible during the short‐term vegan challenge despite dietary counseling, which warrants concern.

show abstract

Role of High-Sensitivity C-reactive Protein (Hs-CRP) in Non-communicable Diseases: A Review

Cited by 37 publications

References 84 publications

Therapeutic hypothermia can cause non-infective C-reactive protein elevating

Therapeutic hypothermia can cause non-infective C-reactive protein elevating

Demographic variables, anthropometric indices, sleep quality, Metabolic Equivalent Task (MET), and developing diabetes in the southwest of Iran

Effects of a Short‐Term Vegan Challenge in Older Adults on Metabolic and Inflammatory Parameters—A Randomized Controlled Crossover Study

Contact Info

Product

Resources

About