Role of hippocampal 5-HT1A receptors on elevated plus maze exploration after a single restraint experience

Netto, Sueli Mendonça; Guimarães, F.S.

doi:10.1016/0166-4328(95)00211-1

Cited by 41 publications

(2 citation statements)

References 17 publications

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“…It has been shown that 5-HT plays a vital role in behaviors related to feeding, − anxiety, fear and aggression, , learning and memory, , reinforcement, − performance monitoring, adjustment to errors, and reproductive behavior . Moreover, 5-HT is important in dealing with stress, , and in processes that govern consciousness …”

Section: -Ht Activity and Signal Throughputmentioning

confidence: 99%

Serotonin Signaling through Lipid Membranes

Kalinichenko,

Kornhuber,

Sinning

et al. 2024

ACS Chem. Neurosci.

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Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental disorders. Primarily, membrane proteins controlling the expression and activity of 5-HT synthesis, storage, release, receptor activation, and inactivation are critical to 5-HT signaling in synaptic and extra-synaptic sites. Moreover, these signals represent information transmission across membranes. Although the lipid membrane environment is often viewed as fairly stable, emerging research suggests significant functional lipid−protein interactions with many synaptic 5-HT proteins. These protein−lipid interactions extend to almost all the primary lipid classes that form the plasma membrane. Collectively, these lipid classes and lipid−protein interactions affect 5-HT synaptic efficacy at the synapse. The highly dynamic lipid composition of synaptic membranes suggests that these lipids and their interactions with proteins may contribute to the plasticity of the 5-HT synapse. Therefore, this broader protein−lipid model of the 5-HT synapse necessitates a reconsideration of 5-HT's role in various associated mental disorders.

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Section: -Ht Activity and Signal Throughputmentioning

confidence: 99%

Serotonin Signaling through Lipid Membranes

Kalinichenko,

Kornhuber,

Sinning

et al. 2024

ACS Chem. Neurosci.

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“…Segundo o estudo de Mahé et al (2004), o SB-258741 atua como um agonista inverso de 5-HT 7r, o que produz a inibição do aumento de AMPc e, portanto, inibição da consolidação de memória. Assim como neste trabalho, outros estudos mostram que a injeção, pósestresse, de outros fármacos no hipocampo, como zimelidina e 8-OH-DPAT também altera as respostas comportamentais no LCE 24 horas depois da exposição ao estresse de restrição (GUIMARÃES et al 1993;MENDONÇA-NETTO;GUIMARÃES, 1996). Guimarães et al (1993) A comparação entre condições, quanto à frequência de entradas nos braços abertos, mostra que os animais submetidos ao estresse de restrição (grupo consolidação) sofreram o efeito da restrição e esse pode ser observado no LCE 24 horas depois, como demonstrado pela literatura BELDA et al, 2008;).…”

Section: Discussionunclassified

Papel dos receptores 5-HT 7 localizados no hipocampo dorsal no desenvolvimento das consequências comportamentais do estresse de restrição

Lorenzo¹

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À instituição de fomento a pesquisa-CAPES pelos recursos e a oportunidade de desenvolver esse projeto, À Universidade de São Paulo pelo espaço que me consentiu avançar acadêmica e pessoalmente, À profa. Dra. Cláudia Maria Padovan pela oportunidade, dedicação e confiança que possibilitaram que eu desenvolvesse esse mestrado, Aos colegas e amigos de laboratório Adriana, Diego, William, Fabiana, Thalita Thiago Viequetin, Tiago Martins, Priscila e Rodrigo pelo companheirismo, discussões, amizade e risadas, e apoio, Ao Thiago Vidotto pela amizade, pelo apoio, risadas e vivência em Ribeirão Preto, E à minha família e amigos de Londrina por sempre me esperarem com um sorriso. RESUMO LORENZO, P. G. P. Papel dos receptores 5-HT 7 localizados no Hipocampo Dorsal no desenvolvimento das consequências comportamentais do Estresse de Restrição. 2016. 49 p. Dissertação (Mestrado)-Faculdade de Medicina,

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Anxiolytic-like effect of group housing on stress-induced behavior in rats

Andrade¹,

Guimarães²

2003

Depress. Anxiety

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Social support is proposed to attenuate behavioral consequences of exposure to uncontrollable stressors. To test this possibility, we compared the effects of two post-stress housing conditions, in pairs or in groups of 10-12 animals per cage, on the behavior of rats tested in the elevated plus-maze (EPM) 24 hr after stress. We also included positive control groups to compare the effects of a standard anxiolytic, diazepam, with those of vehicle. Confirming previous results, diazepam increased the percentage of entries and time spent in the open arms (vehicle, % open entries: 37.0+/-2.7, % time spent in open arms: 17.6+/-1.9; diazepam, % open entries: 46.7+/-2.7, % time spent in open arms: 39.1+/-3.9). Group housing after restraint significantly prevented the anxiogenic effect of restraint (group housing, % open entries: 32.0+/-5.2, % time spent in open arms: 17.6+/-5.0; pair housing, % open entries: 18.7+/-2.2, % time spent in open arms: 6.5+/-1.0). These results suggest that housing conditions could be an important factor in the development of behavioral consequences of stress exposure.

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Role of hippocampal 5-HT1A receptors on elevated plus maze exploration after a single restraint experience

Cited by 41 publications

References 17 publications

Serotonin Signaling through Lipid Membranes

Serotonin Signaling through Lipid Membranes

Papel dos receptores 5-HT 7 localizados no hipocampo dorsal no desenvolvimento das consequências comportamentais do estresse de restrição

Anxiolytic-like effect of group housing on stress-induced behavior in rats

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