Role of Histamine as a Peripheral Sympathetic Neuromediator and its Interrelation with Substance P

Abstract

: With this article we wanted to carry out an educational review about of the fundamental aspects related to the proposal of the existence of a peripheral sympathetic reflex regulated by Histamine, through its effect on presynaptic H3 type receptors, under the interaction of a sensory neurone that would be mediated by Substance P. In this respect, we consider it useful to highlight the role of Histamine, so we discuss some aspects about its history, metabolism, and function, as well as its interaction with H3 type receptors, considered as neuroreceptors, which define and typify it as a neuromediator at both levels of the nervous system, central and peripheral.

CNS-Sparing Histamine H3 Receptor Antagonist as a Candidate to Prevent the Diabetes-Associated Gastrointestinal Symptoms

“…At the hypogastric ganglion level, Atencio et al (2020) hypothesized that SP mediates the vicious circle between histamine and the noradrenergic sympathetic response via noradrenaline release [ 7 ]. Among the four histamine receptor subtypes, numerous reports demonstrated the presence of presynaptic histamine H 3 receptors in the autonomic nervous system.…”

“…Furthermore, histamine H 3 receptors act as autoreceptors and negatively affect histamine release itself [ 12 , 13 , 14 ]. Therefore, the presynaptic histamine H 3 receptor could be crucial in regulating the peripheral sympathetic reflex [ 7 ]. Consistently, Silver et al (2001) demonstrated that activation of histamine H 3 receptors in the peripheral sympathetic terminal inhibits the Na + /H + exchanger (NHE) activity, thus reducing the noradrenaline release during myocardial ischemia [ 15 ].…”