Role of histone modification and DNA methylation in signaling pathways involved in diabetic retinopathy

Shafabakhsh, Rana; Aghadavod, Esmat; Ghayour‐Mobarhan, Majid; Asemi, Zatollah

doi:10.1002/jcp.27844

Cited by 27 publications

(18 citation statements)

References 95 publications

(107 reference statements)

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“…DNA methylation modification is by far the most thoroughly studied epigenetic modification (Shafabakhsh et al, 2019 ). DNA methylation modification is mainly controlled by DNA methyltransferase (DNMT) family proteins ( Table 1 ) (Sahin et al, 2010 ).…”

Section: Effects Of Dna Methylation On β Cell Differentiation and Funmentioning

confidence: 99%

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RETRACTED: Roles of Epigenetic Modifications in the Differentiation and Function of Pancreatic β-Cells

Liu

et al. 2020

Front. Cell Dev. Biol.

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Diabetes, a metabolic disease with multiple causes characterized by high blood sugar, has become a public health problem. Hyperglycaemia is caused by deficiencies in insulin secretion, impairment of insulin function, or both. The insulin secreted by pancreatic β cells is the only hormone in the body that lowers blood glucose levels and plays vital roles in maintaining glucose homeostasis. Therefore, investigation of the molecular mechanisms of pancreatic β cell differentiation and function is necessary to elucidate the processes involved in the onset of diabetes. Although numerous studies have shown that transcriptional regulation is essential for the differentiation and function of pancreatic β cells, increasing evidence indicates that epigenetic mechanisms participate in controlling the fate and regulation of these cells. Epigenetics involves heritable alterations in gene expression caused by DNA methylation, histone modification and non-coding RNA activity that does not result in DNA nucleotide sequence alterations. Recent research has revealed that a variety of epigenetic modifications play an important role in the development of diabetes. Here, we review the mechanisms by which epigenetic regulation affects β cell differentiation and function.

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Section: Effects Of Dna Methylation On β Cell Differentiation and Funmentioning

confidence: 99%

“… Molecular mechanism of DNA methylation (Bansal and Pinney, 2017 ; Ponnaluri et al, 2017 ; Zhou et al, 2018 ; Shafabakhsh et al, 2019 ). DNA methylation modification is mainly controlled by DNMT proteins.…”

Section: Effects Of Dna Methylation On β Cell Differentiation and Funmentioning

confidence: 99%

RETRACTED: Roles of Epigenetic Modifications in the Differentiation and Function of Pancreatic β-Cells

Liu

et al. 2020

Front. Cell Dev. Biol.

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“…Another study revealed that methylation and activation of the matrix metalloproteinase 9 (MMP-9) gene associated with DR has an important role in accelerating apoptosis of retinal vascular endothelium [238]. This indicates that DNA methylation in DR is a highly dynamic process, which involves various epigenetic changes targeting extracellular matrix, manganese superoxide dismutase (MnSOD) also cross-linking with OS, and mitochondrial homeostasis causing mitochondrial dysfunction with subsequent capillary damage [238][239][240][241].…”

Section: Dna Methylationmentioning

confidence: 99%

Importance of the Use of Oxidative Stress Biomarkers and Inflammatory Profile in Aqueous and Vitreous Humor in Diabetic Retinopathy

et al. 2020

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Diabetic retinopathy is one of the leading causes of visual impairment and morbidity worldwide, being the number one cause of blindness in people between 27 and 75 years old. It is estimated that ~191 million people will be diagnosed with this microvascular complication by 2030. Its pathogenesis is due to alterations in the retinal microvasculature as a result of a high concentration of glucose in the blood for a long time which generates numerous molecular changes like oxidative stress. Therefore, this narrative review aims to approach various biomarkers associated with the development of diabetic retinopathy. Focusing on the molecules showing promise as detection tools, among them we consider markers of oxidative stress (TAC, LPO, MDA, 4-HNE, SOD, GPx, and catalase), inflammation (IL-6, IL-1ß, IL-8, IL-10, IL-17A, TNF-α, and MMPs), apoptosis (NF-kB, cyt-c, and caspases), and recently those that have to do with epigenetic modifications, their measurement in different biological matrices obtained from the eye, including importance, obtaining process, handling, and storage of these matrices in order to have the ability to detect the disease in its early stages.

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“…H3K27ac and H3K4me3 modi cations mainly occur around transcriptional start sites (TSSs) [25,26]. At present, the research of histone modi cation mainly focuses on the growth, maturation and activation of germ cells such as oocytes [23] and sperm [27], and the occurrence and development of diseases [28].…”

Section: Introductionmentioning

confidence: 99%

The role of cyadox and recombinant growth hormone (rGH) on the promotion of growth through epigenetics

Liu

Zhu

et al. 2020

Preprint

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Background: Cyadox is an effective growth-promoting antibiotic, which is similar to the role of recombinant growth hormone (rGH). Current studies have shown that cyadox can promote animal growth through altering intestinal microflora, improving protein utilization and increasing protein synthesis. Increasing evidence suggests that epigenetics are also closely related to growth. However, the potential role of epigenetics in the cyadox for growth has not been explored. Results: Here, we used recombinant growth hormone (rGH) and cyadox to study the relationship between growth and changes in epigenetics including DNA methylation, histone modification and chromatin structure. Bisulfite DNA sequencing (BSP) assay suggested that cyadox and rGH treatments increased IGF-1 expression partially by hypomethylation at CpG sites within the promoter region of IGF-1, which was regulated by DNA methyltransferases (DNMTs). We also observed an enrichment of H3K4me3 and H3K27ac at the promoter regions of IGF-1 by ChIP-qPCR assay, which contributed to an increase in IGF-1 transcription. In addition, immunofluorometric assay displayed cellular accessible chromatin structure following the treatment of cyadox and rGH, facilitating the combination of transcription factors and DNA and thus enhancing gene transcription. Conclusions: Taken together, our findings indicated that cyadox and rGH promote cell growth partially through epigenetic changes, providing a prospect for the development of animal growth-promoting drugs in the future.

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Role of histone modification and DNA methylation in signaling pathways involved in diabetic retinopathy

Cited by 27 publications

References 95 publications

RETRACTED: Roles of Epigenetic Modifications in the Differentiation and Function of Pancreatic β-Cells

RETRACTED: Roles of Epigenetic Modifications in the Differentiation and Function of Pancreatic β-Cells

Importance of the Use of Oxidative Stress Biomarkers and Inflammatory Profile in Aqueous and Vitreous Humor in Diabetic Retinopathy

The role of cyadox and recombinant growth hormone (rGH) on the promotion of growth through epigenetics

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