Role of Hog1-mediated stress tolerance in biofilm formation by the pathogenic fungus Trichosporon asahii
Yasuhiko Matsumoto,
Mei Nakayama,
Yuta Shimizu
et al.
Abstract:Trichosporon asahii, a dimorphic fungus, causes bloodstream infections in immunocompromised patients with neutropenia. Biofilms are formed on the surfaces of medical devices such as catheters as T. asahii transitions morphologically from yeast to hyphae in the host environment. Oxidative stress tolerance and morphological changes of T. asahii are regulated by Hog1, a mitogen-activated protein kinase. The role of Hog1 in the biofilm formation by T. asahii, however, has remained unknown. In the present study, we… Show more
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