Role of Homeobox Genes in Tooth Morphogenesis: A Review

Suryadeva, Sreevalli

doi:10.7860/jcdr/2015/11067.5606

Cited by 18 publications

(15 citation statements)

References 27 publications

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“…Por otro lado, Suryadeva y Begum en 2015 mencionan que la formación dental es un proceso genéti-camente complicado en el que inicialmente se especifica el tipo, la posición, el tamaño de cada germen dental, y por último, los procesos de formación del esmalte y la dentina 9 . Así mismo, refieren que las interacciones recíprocas entre los tejidos ectodérmi-cos y ectomesenquimales regulan las etapas clave en el proceso de odontogénesis, denominadas: iniciación, morfogénesis y diferenciación.…”

Section: Mecanismos Moleculares Implicados En La Odontogénesisunclassified

“…Así mismo, refieren que las interacciones recíprocas entre los tejidos ectodérmi-cos y ectomesenquimales regulan las etapas clave en el proceso de odontogénesis, denominadas: iniciación, morfogénesis y diferenciación. A continuación se describen cada una de estas etapas 9 . Etapa de iniciación: el ciclo vital de los órganos dentarios comprende una serie de cambios quími-cos, morfológicos y funcionales que comienzan en la sexta semana de vida intrauterina y continúa a lo largo de toda la vida dental.…”

Section: Mecanismos Moleculares Implicados En La Odontogénesisunclassified

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Avances en La Genética De La Formación Dental: Una Revisión

2014

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RESUMENEl desarrollo de las estructuras dentarias es el resultado de un complejo proceso de interacciones recíprocas y secuenciales entre células epiteliales y mesenquimáticas. La organogénesis dental está bajo un estricto control genético donde intervienen factores de crecimiento, de transcripción, moléculas de señalización y proteínas que determinan las posiciones, número y forma de los diferentes dientes. El objetivo de esta revisión fue describir los aspectos embriológicos y moleculares de la formación dental y las anomalías asociadas a un defecto en el patrón genético. Se realizó una búsqueda de literatura en PubMed, Dentistry & Oral Sciences Source, Science Direct y Scielo. Se concluye que continúan los avances en genética dental que han permitido entender cómo las alteraciones de diferentes genes, factores reguladores y proteínas son los responsables de diversas anomalías dentales. Los avances en la bioingeniería dental podrán resolver muchos de los interrogantes que hoy tenemos. [Verbel N, Alfaro OA, Torres EA. Avances en la genética de la formación dental: una revisión. Ustasalud. 2014; 13 (2) ADVANCES IN THE GENETICS OF DENTAL DEVELOPMENT: A REVIEW ABSTRACTThe development of dental structures is the result of a complex process of reciprocal and sequential interactions between epithelial and mesenchymal cells. Tooth organogenesis is under strict genetic control, where involved growth factors, transcription factors, signaling molecules and proteins that determine the positions, number and shape of the individual teeth. The objective of this review was to describe the embryological and molecular aspects of dental development and the anomalies associated with a defect in the gene pattern. A literature search was done in databases such as PubMed, Dentistry & Oral Sciences Source, Science Direct and Scielo. We concluded that dental genetics have a steady progress, which involves frequent updating and these advances have allowed to understand how changes in different genes, regulatory factors and proteins are responsible for various dental anomalies. The advances in dental bioengineering can solve many of the questions we have today.Keywords: Genetics, Odontogenesis, Bioengineering, Pathology.Recibido para publicación: 13 de octubre de 2014. Aprobado para publicación: 23 de noviembre de 2014. INTRODUCCIÓNEl desarrollo normal del individuo depende de dos grandes factores. Estos son la regulación genética, definida como la influencia del plan genético establecido en el DNA y en el contenido en los cromosomas y la regulación epigenética, que incluye la influencia de los factores externos que inciden en el desarrollo 1 . Ferraris y Muñoz afirman que las célu-las de la cresta neural emigran hacia el mesodermo de los arcos braquiales para dar origen a componentes esqueléticos, óseos y cartilaginosos que incluyen los componentes de los tejidos conectivos que formarán el complejo pulpodentinario y los tejidos de sostén del diente como el hueso, ligamento periodontal y cemento 2 .En el curso del desarrollo de los órg...

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Section: Mecanismos Moleculares Implicados En La Odontogénesisunclassified

Avances en La Genética De La Formación Dental: Una Revisión

2014

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“…Both SNPs were suggestively significant in the whole-sample GWAS. homeobox genes are involved in tooth morphogenesis [Suryadeva and Khan, 2015]; however, specific data on the homeobox A gene family in relation to tooth development are not available. ZWINT is involved in kinetochore function [Woo Seo et al, 2015], but its association with dental tissues is not studied.…”

Section: Gwas Using the Extreme Opposite Approachmentioning

confidence: 99%

“…The other was near the gene msh homeobox 1 (MSX1) and another in the gene glycine receptor α 3 (GLRA3). The cluster near MSX1 deserves special attention since MSX1 is one of the most important genes involved in tooth development [Suryadeva and Khan, 2015] and can be considered as one of the most interesting findings using this approach. GLRA3 encodes a member of the ligand-gated ion channel protein family, and there are no data on it considering oral environment.…”

Section: Gwas Using the Extreme Opposite Approachmentioning

confidence: 99%

Genome-Wide Association Study of Erosive Tooth Wear in a Finnish Cohort

et al. 2018

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Erosive tooth wear is defined as irreversible loss of dental tissues due to intrinsic or extrinsic acids, exacerbated by mechanical forces. Recent studies have suggested a higher prevalence of erosive tooth wear in males, as well as a genetic contribution to susceptibility to erosive tooth wear. Our aim was to examine erosive tooth wear by performing a genome-wide association study (GWAS) in a sample of the Northern Finland Birth Cohort 1966 (n = 1,962). Erosive tooth wear was assessed clinically using the basic erosive wear examination. A GWAS was performed for the whole sample as well as separately for males and females. We identified one genome-wide significant signal (rs11681214) in the GWAS of the whole sample near the genes PXDN and MYT1L. When the sample was stratified by sex, the strongest genome-wide significant signals were observed in or near the genes FGFR1, C8orf86, CDH4, SCD5, F2R, and ING1. Additionally, multiple suggestive association signals were detected in all GWASs performed. Many of the signals were in or near the genes putatively related to oral environment or tooth development, and some were near the regions considered to be associated with dental caries, such as 2p24, 4q21, and 13q33. Replications of these associations in other samples, as well as experimental studies to determine the biological functions of associated genetic variants, are needed.

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“…Homeobox genes play important roles in tooth development (Suryadeva and Khan 2015). In mouse, Msx1 and Msx2 show different expression patterns during early tooth development (MacKenzie et al 1992), and are suggested to have potentially different roles during this process (Satokata and Maas 1994;Satokata et al 2000).…”

Section: Selected Pathway Comparisons Among Different Tooth Developmementioning

confidence: 99%

The Molecular Circuit Regulating Tooth Development in Crocodilians

et al. 2016

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Alligators have robust regenerative potential for tooth renewal. In contrast, extant mammals can either renew their teeth once (diphyodont dentition, as found in humans) or not at all (monophyodont dentition, present in mice). Previously, the authors used multiple mitotic labeling to map putative stem cells in alligator dental laminae, which contain quiescent odontogenic progenitors. The authors demonstrated that alligator tooth cycle initiation is related to β-catenin/Wnt pathway activity in the dental lamina bulge. However, the molecular circuitry underlying the developmental progression of polyphyodont teeth remains elusive. Here, the authors used transcriptomic analyses to examine the additional molecular pathways related to the process of alligator tooth development. The authors collected juvenile alligator dental laminae at different developmental stages and performed RNA-seq. This data shows that Wnt, bone morphogenetic protein (BMP), and fibroblast growth factor (FGF) pathways are activated at the transition from pre-initiation stage (bud) to initiation stage (cap). Intriguingly, the activation of Wnt ligands, receptors and co-activators accompanies the inactivation of Wnt antagonists. In addition, the authors identified the molecular circuitry at different stages of tooth development. The authors conclude that multiple pathways are associated with specific stages of tooth development in the alligator. This data shows that Wnt pathway activation may play the most important role in the initiation of tooth development. This result may offer insight into ways to modulate the genetic controls involved in mammalian tooth renewal.

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Role of Homeobox Genes in Tooth Morphogenesis: A Review

Cited by 18 publications

References 27 publications

Avances en La Genética De La Formación Dental: Una Revisión

Avances en La Genética De La Formación Dental: Una Revisión

Genome-Wide Association Study of Erosive Tooth Wear in a Finnish Cohort

The Molecular Circuit Regulating Tooth Development in Crocodilians

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