Role of host interleukin 1β gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive Turkish patients with dyspepsia

Erzın, Yusuf; Köksal, Vedat; Altun, Sibel; Dobrucalı, Ahmet; Aslan, Mustafa; Erdamar, Sibel; Göksel, Süha; Dırıcan, Ahmet; Kocazeybek, Bekir

doi:10.1007/s00535-008-2220-7

Cited by 30 publications

(34 citation statements)

References 33 publications

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“…In Portuguese and Thai populations, babA2 is not a biomarker for peptic ulcer disease or gastric cancer (52,110). However, for strains isolated from Germany, Turkey, or northern Portugal, babA2 expression is associated with the severity of gastric disease (26,86,113).…”

Section: Adhesins and Ompsmentioning

confidence: 99%

Helicobacter pyloriand Gastric Cancer: Factors That Modulate Disease Risk

Wroblewski¹,

2010

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SUMMARY Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's population. Infection with H. pylori causes chronic inflammation and significantly increases the risk of developing duodenal and gastric ulcer disease and gastric cancer. Infection with H. pylori is the strongest known risk factor for gastric cancer, which is the second leading cause of cancer-related deaths worldwide. Once H. pylori colonizes the gastric environment, it persists for the lifetime of the host, suggesting that the host immune response is ineffective in clearing this bacterium. In this review, we discuss the host immune response and examine other host factors that increase the pathogenic potential of this bacterium, including host polymorphisms, alterations to the apical-junctional complex, and the effects of environmental factors. In addition to host effects and responses, H. pylori strains are genetically diverse. We discuss the main virulence determinants in H. pylori strains and the correlation between these and the diverse clinical outcomes following H. pylori infection. Since H. pylori inhibits the gastric epithelium of half of the world, it is crucial that we continue to gain understanding of host and microbial factors that increase the risk of developing more severe clinical outcomes.

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Section: Adhesins and Ompsmentioning

confidence: 99%

Helicobacter pyloriand Gastric Cancer: Factors That Modulate Disease Risk

Wroblewski¹,

2010

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“…(forward) and 5´-GGAATCTTCCCACTTACAGATGG-3´ (reverse) [32]. PCR was performed under the conditions described by Erzin et al, with minor modifications [32].…”

Section: Identification Of Il-1 Gene Polymorphismsmentioning

confidence: 99%

“…PCR was performed under the conditions described by Erzin et al, with minor modifications [32]. The PCR products were digested with the restriction enzyme DdeI and then analyzed by electrophoresis on a 2.5% agarose gel with ethidium bromide staining.…”

Section: Identification Of Il-1 Gene Polymorphismsmentioning

confidence: 99%

“…The PCR products were digested with the restriction enzyme DdeI and then analyzed by electrophoresis on a 2.5% agarose gel with ethidium bromide staining. The genotypes were designated as follows: C/C -two bands of 140 and 49 bp; C/T -four bands of 140, 109, 49 and 31 bp and T/T -three bands of 109, 49 and 31 bp [32].…”

Section: Identification Of Il-1 Gene Polymorphismsmentioning

confidence: 99%

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Relationship of interleukin-1B gene promoter region polymorphism with Helicobacter pylori infection and gastritis

Ramis

Vianna

Halicki

et al. 2015

J Infect Dev Ctries

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Introduction: Helicobacter pylori infection is associated with gastritis, peptic ulcer disease and gastric carcinoma. The severity of damage is determined by the interplay between environmental/behavioral factors, bacterial pathogenicity genes and host genetic polymorphisms that can influence the secretion levels of inflammatory cytokines. Accordingly, this study aimed to identify polymorphisms in the IL-1B and IL-1RN genes and their associations with H. pylori infection, cagA gene of H. pylori, and gastroduodenal diseases.

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“…Özellikle IL-1β 31C/511T ve IL-1RN 2x ve TNF-a308 G/A allelleri çok fazla IL-1β salınmasına yolaçar. Hipoklorhidrinin artmasına neden olarak ve gastrik karsinogenezde rol almaktadır (23,24) . Ayrıca normalden daha düşük ekspresyon seviyelerine neden olan IL-10 polimorfizmleri, intestinal metaplazi riskinde artış ile ilişkili bulunmuştur (25) .…”

Section: Gastrik Kanser Ve Polimorfizmlerunclassified

The Place of Helicobacter pylori in Human Health; Where is it Standing in the Balance Between Harm and Benefit?

Caliskan¹,

Kocazeybek²

2015

TMCD

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Role of host interleukin 1β gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive Turkish patients with dyspepsia

Abstract: When analyzed together with host genetic factors, the well established bacterial risk factor babA2 seems to be the most important predictor of malignant disorders, and the presence of the IL-1B-31TT genotype emerges as a protective factor against them.

Cited by 30 publications

References 33 publications

Helicobacter pyloriand Gastric Cancer: Factors That Modulate Disease Risk

Helicobacter pyloriand Gastric Cancer: Factors That Modulate Disease Risk

Relationship of interleukin-1B gene promoter region polymorphism with Helicobacter pylori infection and gastritis

The Place of Helicobacter pylori in Human Health; Where is it Standing in the Balance Between Harm and Benefit?

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