Role of Human Epicardial Adipose Tissue–Derived miR-92a-3p in Myocardial Redox State

Carena, Maria Cristina; Badi, Ileana; Polkinghorne, Murray; Akoumianakis, Ioannis; Psarros, Costas; Wahome, Elizabeth; Kotanidis, Christos; Akawi, Nadia; Antonopoulos, Alexios S; Chauhan, Jagat; Sayeed, Rana; Krasopoulos, George; Srivastava, Vivek; Farid, Shakil; Walcot, Nicholas; Douglas, Gillian; Channon, K M; Casadei, Barbara; Antoniades, Charalambos

doi:10.1016/j.jacc.2023.05.031

Cited by 10 publications

(1 citation statement)

References 36 publications

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“…Epicardial adipose tissue (EAT) refers to a type of visceral fat located between the myocardial surface and the visceral layer of the pericardium. EAT has been confirmed as an independent risk factor for accelerated progression of subclinical coronary atherosclerosis 1 ; it is correlated with abdominal fat mass and obesity severity while showing an independent association with cardiovascular events 2 . EAT is considered to be an independent predictor of visceral obesity and may be closely associated with the pathogenesis of metabolic syndrome (MS) 3 , 4 , adverse clinical outcomes of COVID-19 5 – 7 , coronary artery disease, and diabetes 8 .…”

Section: Introductionmentioning

confidence: 99%

Association between epicardial adipose tissue and myocardial work by non-invasive left ventricular pressure-strain loop in people with suspected metabolic syndrome

Sun,

Xiao,

Zhao

et al. 2023

Sci Rep

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Given the inconsistent results on the prognostic significance of epicardial adipose tissue (EAT), the purpose of the present study was to investigate the association of EAT thickness and myocardial work by non-invasive left ventricular pressure-strain loop in people with suspected metabolic syndrome (MS). A total of 194 participants imaged with echocardiography were evaluated. In accordance with the median EAT thickness, MS patients fell into thin EAT group and thick EAT group. Conventional echocardiographic parameters, global longitudinal strain (GLS) and the global myocardial work parameters obtained by pressure-strain loop analysis, comprising the global work index (GWI), global work efficiency (GWE), global constructive work (GCW) and global wasted work (GWW) were compared between the two groups. In comparison with the thin EAT group, thick EAT group achieved significantly higher values in interventricular septal thickness, end-diastolic left ventricular posterior wall thickness, left ventricular mass index and GWW (p < 0.05). while the absolute value of GLS, GWI, GCW, and GWE were notably lower in the thick EAT group (p < 0.001). EAT thickness showed a significant correlation with GWI and GCW (r = − 0.328, p = 0.001; r = − 0.253, p = 0.012), and also independently correlated with GWI and GCW in the multivariate regression analysis (β = − 0.310, p = 0.001; β = − 0.199, p = 0.049). EAT thickness is associated with left ventricular myocardial function in subjects with suspected metabolic syndrome, independently of other risk factors. Further studies are supposed to ensure the causal associations and related mechanisms.

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