Role of Human Epididymis Protein 4 in Tumour Angiogenesis

Dubey, Harshita; Modi, Mansi; Verma, Saransh; Sinha, Ruchi; Goel, Harsh; Ranjan, Amar; Tanwar, Pranay; Chopra, Anita; Rahul, Ekta; Ranjan, Lawanya; Verma, Neeraj; Chauhan, D; Mahkam, Rani Kumari; Dubey, Utkarsh

doi:10.5772/intechopen.105678

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He4 and Immune Response1

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2023

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“…As discussed before, a positive correlation between HE4 serum levels and IL-8 has been described in patients with microvascular ovarian cancer, affecting trafficking of cytotoxic T lymphocyte; the trip of these cells into the tumor tissue is dysregulated and suppressed as a consequence of HE4 increase [ 83 ].…”

Section: He4 and Immune Responsementioning

confidence: 99%

Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis

Anastasi,

Farina,

Granato

et al. 2023

IJMS

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Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most interestingly, HE4 plays a unique role in OC as it has been implicated not only in OC diagnosis but also in the prognosis and recurrence of this lethal neoplasm, actually acting as a clinical biomarker. There are several evidence about the predictive power of HE4 clinically, conversely less has been described concerning its role in OC oncogenesis. Based on these considerations, the main goal of this review is to clarify the role of HE4 in OC proliferation, angiogenesis, metastatization, immune response and also in the development of targeted therapy. Through a deeper understanding of its functions as a key molecule in the oncogenetic processes underlying OC, HE4 could be possibly considered as an essential resource not only for diagnosis but also for prognosis and therapy choice.

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Section: He4 and Immune Responsementioning

confidence: 99%