Role of Human Papillomavirus and Its Association With an Indian OSCC Subjects

Abstract

Oral Cancer; especially Oral Squamous Cell Carcinoma (OSCC) is the eighth most common cancer all over the globe and most common neoplasm in India. Due to the tobacco addiction pattern in Indians specially Guajarati’s are well known for high consumption of tobacco in non-smoking form may have the high-risk for developing oral cancer. Apart of this, Human papilloma virus(HPV) might be one of the cause for developing oral cancer hence, the proposed study was carried out for 50 primary OSCC subjects from January 2018 to October 2018. Tumour specimens were HPV-genotyped by type specific PCR method. Statistical analyses were performed by Fisher’s exact test. The present study identified 4% HPV infection frequency in advanced staged OSCC Indian subset, where One OSCC stage IV patient observed with HPV 16 infection and one OSCC stage III patient with HPV 18. Our finding differs with rest of the population, as the region have high amount of consumption of tobacco. Current study need to be validated in larger sample size to get the clear view for association of HPV with oral cancer.