Role of Human Papillomavirus Genotype in Prognosis of Early-Stage Cervical Cancer Undergoing Primary Surgery

Lai, Chyong‐Huey; Chang, Chee Jen; Huang, Hsuan-Rong; Hsueh, Swei; Chao, Angel; Yang, Jung Erh; Lin, Cheng Tao; Huang, Shang Lang; Hong, Ji Hong; Chou, Hung Hsueh; Wu, Ting-Jung; Huang, Kuo‐Lun; Wang, Chun Chieh; Chang, Ting Chang

doi:10.1200/jco.2007.11.2995

Cited by 124 publications

(128 citation statements)

References 31 publications

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“…Consistently reported independent adverse prognostic factors for patients with early-stage cervical cancer after RH include higher FIGO stage, lymph node metastasis, parametrial involvement, depth of cervical stromal invasion, tumour size and LVSI (Look et al, 1996;Lai et al, 2007;Kasamatsu et al, 2009). We also found that these factors were significant in univariate analysis, although only lymph node metastasis, parametrial involvement and tumour size were significant in multivariate analysis.…”

Section: Discussionmentioning

confidence: 50%

Outcomes after radical hysterectomy in patients with early-stage adenocarcinoma of uterine cervix

Kim

et al. 2010

Br J Cancer

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BACKGROUND: To determine the prognostic factors and treatment outcomes of patients with early-stage adenocarcinoma (AdCa) of uterine cervix who underwent radical hysterectomy (RH). METHODS: Patients with early-stage squamous cell carcinoma (SCCa) of the uterine cervix who underwent RH were compared with patients with AdCa by multivariate analysis. RESULTS: A total of 1218 patients were eligible, of which 996 (81.8%) had SCCa and 222 (18.2%) had AdCa. In multivariate analysis, parametrial involvement and lymph node metastasis were significant factors for both recurrence-free survival(RFS) and overall survival (OS) of patients with AdCa, whereas age, tumour size, parametrial involvement and lymph node metastasis were significant factors for both RFS and OS of patients with SCCa. After adjusting for significant prognostic factors, patients with AdCa had significantly poorer RFS (odds ratio (OR) ¼ 2.07, 95% confidence interval (CI) ¼ 1.37 -3.12, P ¼ 0.001) and OS (OR ¼ 2.56, 95% CI ¼ 1.65 -3.96, Po0.001) than patients with SCCa. Recurrence outside the pelvis was more frequent in AdCa than in those with SCCa (75 vs 57.8%, P ¼ 0.084). CONCLUSION(S): Although RH is still acceptable for treatment of patients with AdCa, a more effective systemic adjuvant therapy is required.

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Section: Discussionmentioning

confidence: 50%

Outcomes after radical hysterectomy in patients with early-stage adenocarcinoma of uterine cervix

Kim

et al. 2010

Br J Cancer

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“…23,[29][30][31] The second point concerns the differential prognostic value of HPV genotypes in invasive cancer. We 16 and others 14,22,28,[32][33][34][35][36][37][38][39][40] reported an unfavourable outcome of tumours associated with HPV18 as compared with those associated with HPV16 or with intermediate-risk HPV types. In this work, based on the analysis of a larger number of cases with a long follow up, the better outcome of tumours associated with intermediate-risk HPV was confirmed, but the respective prognostic value of HPV18 vs. HPV16 showed little differences.…”

Section: Discussionmentioning

confidence: 99%

“…The conclusion that virtually all cervical cancer were HPV positive 1 has not been confirmed in later studies. Taking into account the overall population of 2,717 patients corresponding to recent reports [22][23][24][25][26][27][28] and this study, the global rate of HPV negative invasive carcinoma is 10.1%, ranging from 2% 26 to 26.1%. 24 Several reasons may be evoked to account for potential false negativity of viral analysis (rare or not yet cloned HPV, loss of viral DNA sequences during the tumour process, lack of methodology.…”

Section: Discussionmentioning

confidence: 99%

Different outcome of invasive cervical cancer associated with high‐risk versus intermediate‐risk HPV genotype

Crémoux

Rochefordière

Savignoni

et al. 2008

Intl Journal of Cancer

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Human papillomavirus (HPV) DNA sequences are associated with the large majority of invasive cervical carcinoma but the role of specific genotype(s) in the outcome of the disease is still debated. To determine the viral epidemiology in the French population of patients and the prognostic value of HPV genotypes in cervical cancer, we performed a retrospective study in 515 patients treated in our Institution from 1985 to 2005. Ninety-six percent of the cases were found associated with HPV DNA whereas 4% remained HPV negative. High-risk HPV 16/18 genotypes were found in 70% of the cases. HPV 18 was more frequently associated with adenocarcinoma (40.6%) than HPV 16 (10.4%) and found in tumours developed in younger women (mean age, 45.8 years) than HPV 16 (48.3 years) or other HPV types (53.6 years). In multivariate analysis, node involvement (p < 0.0001), parametria invasion (p 5 0.009), tumour size (p 5 0.01) and HPV status (p 5 0.02) were associated with disease-free survival (median follow-up 95 months). Disease outcome was better in tumours associated with intermediate risk HPV types (HPV 31,33,35,39, 52, 53, 58, 59, 73) than in tumours with high oncogenic types (HPV 16, 18, 45) (p 5 0.03). Node status and tumour size remained prognostic factor for overall survival. Our data show that HPV genotype is one of the biological factors associated with the outcome of cervical cancer. One third of invasive carcinoma were not associated with HPV 16/18, indicating that the screening for cervical neoplasia should be maintained after prophylactic vaccination against these HPV genotypes. ' 2008 Wiley-Liss, Inc.Key words: cervical cancer; HPV; prognosis Human papillomavirus (HPV) DNA sequences are associated with most of invasive cervical carcinoma worldwide 1 and the role of HPV as a causative agent of cervical neoplasia is well documented. 2 There is a large plurality of HPV types since more than 100 different genotypes have been identified 3 among which more than 40 infect ano-genital mucosa. Histological and virological analyses have shown that 3 groups of genital HPV could be identified according to their oncogenic properties. Low-risk HPVs (HPV6,11,42,43, 44. . .), present in low grade cervical intraepithelial neoplasia (CIN) but rare in invasive cancer, intermediaterisk HPVs (HPV 31,33,35, 51, 52, 58. . .), more prevalent in CIN than in invasive cancer, and high-risk HPVs (HPV16, 18, 45, 56. . .), more frequently found in invasive carcinoma than in CIN. 4 Experimental data have disclosed that high-risk E6 and E7 oncoprotein act in the tumour process by interfering with cell cycle G1-S checkpoint. 5 Virological epidemiology data show that HPV16 and HPV18 are the most prevalent genotypes found in invasive carcinoma worldwide but that there are significant geographic variations in the prevalence of less common genotypes. 6 In the perspective of prophylactic vaccination, it is thus necessary to accurately determine the prevalence of the different HPV types in cervical cancer at country level. Moreover, controversial data...

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“…Vermutlich lassen sich mit zunehmender Datenlage auch bezüglich des Überlebens der Tumorpatienten Unterschiede zwischen den einzelnen Subtypen definieren. So ist beim Zervixkarzinom insbesondere HPV18 mit einer schlechteren Prognose assoziiert worden [14]. Auch ist zu bedenken, dass zunehmend auch HPV-Typen der Niedrigrisikogruppe mit malignen Tumorerkrankungen assoziiert wurden, sodass zwar mit einem geringeren Krebsrisiko als bei den Hochrisikotypen zu rechnen ist, dieses aber keinesfalls unberücksichtigt bleiben sollte (.…”

Section: Diskussio N Und Schlussfo Lgerungenunclassified

HPV bei nichtgynäkologischen Tumoren

Petersen

Klein

2008

Pathologe

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Role of Human Papillomavirus Genotype in Prognosis of Early-Stage Cervical Cancer Undergoing Primary Surgery

Abstract: The independent prognostic value of HPV genotype is confirmed in this study. The prognostic models could be useful in counseling patients and stratifying patients in future clinical trials.

Cited by 124 publications

References 31 publications

Outcomes after radical hysterectomy in patients with early-stage adenocarcinoma of uterine cervix

Outcomes after radical hysterectomy in patients with early-stage adenocarcinoma of uterine cervix

Different outcome of invasive cervical cancer associated with high‐risk versus intermediate‐risk HPV genotype

HPV bei nichtgynäkologischen Tumoren

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