Role of Humoral Antibodies in Resistance to <i>Mycoplasma pneumoniae</i> Pneumonia in Hamsters

Hayatsu, Eizo; Kawakubo, Yasuaki; Yayoshi, Masumi; Araake, Minako; Yoshioka, Morimasa; Nishiyama, Yasukazu

doi:10.1111/j.1348-0421.1980.tb02861.x

Cited by 9 publications

(12 citation statements)

References 14 publications

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“…hamsters previously infected with M. pneumoniae were found to be more resistant to pneumonia upon reinfection, even if they had low serum antibody titers (10,12,16). However, in our previous investigations, resistance to M. pneumoniae infection in hamsters corresponded to serum antibody titers in animals actively immunized with adjuvant vaccine (17) or adoptively immunized with serum preparations (17,18).…”

mentioning

confidence: 69%

“…Conversely, high-titer serum antibody induced by parenteral administration of killed M. pneumoniae rendered almost no protection in hamsters (10). We reported previously that an inactivated adjuvant vaccine prepared with strain FH-P24 induced a high level of serum antibody in hamsters and showed a very high protective potency (17), and animals pretreated with high-titer antiserum were resistant to the challenge (17,18). The results support the findings of Chanock et al (7,22,28) and McCormick et al (20) who stated that human resistance to mycoplasmal pneumonia is correlated with the' presence of naturally acquired or vaccine-induced serum antibody.…”

Section: Discussionmentioning

confidence: 99%

“…The results support the findings of Chanock et al (7,22,28) and McCormick et al (20) who stated that human resistance to mycoplasmal pneumonia is correlated with the' presence of naturally acquired or vaccine-induced serum antibody. Hence some of these investigators have suggested that mechanisms other than humoral immunity are not excluded in human resistance to M. pneumoniae (10,12,16,18). …”

Section: Discussionmentioning

confidence: 99%

“…However, in our previous investigations, resistance to M. pneumoniae infection in hamsters corresponded to serum antibody titers in animals actively immunized with adjuvant vaccine (17) or adoptively immunized with serum preparations (17,18).…”

mentioning

confidence: 99%

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Immunological Responses of Hamsters in the Acquired Immune State to Mycoplasma pneumoniae Infection

Hayatsu

Kawakubo

Yayoshi

et al. 1981

Microbiology and Immunology

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Protective effects of vaccination of hamsters against Mycoplasma pneumoniae infection, evaluated according to the recovery of mycoplasmas and histopathological changes in the respiratory tract after challenge infection, persisted for at least 6 months after the final vaccination. Serum antibody levels reached a maximum in the second week after the last vaccination and decreased markedly between the first and the third months, but increased again in sera obtained from animals given booster injections. Metabolism-inhibiting antibodies were detected in bronchial washings of animals showing high resistance obtained by vaccinal or passive immunization. Antiserum transfer was also effective for protection but cell-mediated immune responses were not demonstrated in any animals up to 6 months after the vaccination. Even after 10 months, suppression of both mycoplasmal proliferation and lung lesions was apparent, and a single dose of the vaccine induced a significant booster effect. These findings suggest that (I) humoral immunity is more important than cell-mediated immunity in resistance of hamsters to M. pneumoniae pneumonia, and (2) the antibody secreted in the respiratory tract may be involved in the local defense mechanisms.Mycoplasma pneumoniae, a respiratory tract pathogen, causes bronchitis and pneumonia in children and young adults. Epidemiological problems have been raised, especially in closed populations such as kindergartens, primary schools, and military forces (1,6,15,26,29). M. pneumoniae pneumonia responds satisfactorily to the appropriate antibiotics, but the organisms are not effectively eradicated from the respiratory tract (14,23). Efforts have been directed toward the development of a vaccine for prophylaxis (7,10,12,17,25).Resistance of humans to M. pneumoniae infection has been reported to be correlated directly with the presence of serum antibodies (7,20,22,28). In hamsters, a high level of serum antibody produced by parenteral vaccination with killed M. pneumoniae was not accompanied by protection (l 0) . On the other hand, 1255

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mentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Immunological Responses of Hamsters in the Acquired Immune State to Mycoplasma pneumoniae Infection

Hayatsu

Kawakubo

Yayoshi

et al. 1981

Microbiology and Immunology

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“…Although the factors which participate in this resistance are not well understood, humoral antibody appears to be one important factor. Rabbit anti-M. pneumoniae hyperimmune serum and its IgG fraction can protect hamsters against mycoplasmal respiratory disease (12). Resistance of mice to M. pulmonis infection may also be related to the presence of IgG 1, IgG 2, and/or IgA antibody in lung washings (20,21).…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Colostrum in Mycoplasma pneumoniae Infection Induced in Infant Mice

Katsura

Kanamori

Kitamoto

et al. 1985

Microbiology and Immunology

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The immunological responses and mechanism of maternal immunity in Mycoplasma pneumoniae infection of mice were investigated.ICR female mice, 4 weeks old, and infant mice, 2 to 4 days old, were infected with M. pneumoniae. Anti-M. pneumoniae antibodies in serum and colostrum were determined by enzymelinked immunosorbent assay. The specific IgG antibody production persisted for 9 months or longer in both the young and infant mice. These infected mice were protected from rechallenge with M. pneumoniae. In addition, the infected dams conferred passive immunity on their offspring.The infant mice born to uninfected normal dams were protected from the challenge with M. pneumoniae when fed by infected foster dams.Conversely, the infant mice born to infected ,dams were not protected from the challenge with M. pneumoniae when the infants were fed by uninfected dams. The specific IgG antibody appeared in serum of infant mice inoculated orally with M. pneurnoniae-infected mouse serum and the infants were protected from challenge with M. pneumoniae, while the infants given protein A-absorbed serum were not protected from the challenge. These results suggest that one of the factors involved in the resistance of infant mice to M. pneumoniae infection is the specific IgG antibody present in the colostrum rather than the result of transplacental transfer.

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Bases for the early immune response after rechallenge or component vaccination in an animal model of acute Mycoplasma pneumoniae pneumonitis

Cimolai

Mah

Taylor

et al. 1995

Vaccine

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Role of Humoral Antibodies in Resistance to Mycoplasma pneumoniae Pneumonia in Hamsters

Cited by 9 publications

References 14 publications

Immunological Responses of Hamsters in the Acquired Immune State to Mycoplasma pneumoniae Infection

Immunological Responses of Hamsters in the Acquired Immune State to Mycoplasma pneumoniae Infection

Protective Effect of Colostrum in Mycoplasma pneumoniae Infection Induced in Infant Mice

Bases for the early immune response after rechallenge or component vaccination in an animal model of acute Mycoplasma pneumoniae pneumonitis

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