Role of Hyaluronic Acid in Selected Malignant Neoplasms in Women

Markowska, Anna; Antoszczak, Michał; Markowska, Janina; Huczyński, Adam

doi:10.3390/biomedicines11020304

Cited by 8 publications

(3 citation statements)

References 101 publications

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“…Hyaluronic acid (HA) is another popular biomaterial most commonly used post-operatively, particularly in the form of a hydrogel, and can be combined with both natural molecules as well as synthetic polymers (Abatangelo et al, 2020). However, care must be taken when using HA, as it has been shown to regulate the TME and promote the malignant phenotype of cancer cells, and lead to multidrug resistance (Markowska et al, 2023). So, whilst HA is beneficial in applications such as wound repair, studies have shown that it can also effectively feed the cancer, causing it to grow and spread.…”

Section: Biomaterial-based Scaffoldsmentioning

confidence: 99%

The road after cancer: biomaterials and tissue engineering approaches to mediate the tumor microenvironment post-cancer treatment

Westwood,

Nixon,

Emmerson

et al. 2024

Front. Biomater. Sci.

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Cancer affects tens of millions of the world’s population each year with a stark mortality rate. It is well established that in order to be effective in treating solid tumor cancers, the current treatment methods used often sacrifice surrounding healthy tissue and cause damage at the site of treatment, inducing changes to the surrounding microenvironment. These changes to the microenvironment can lead to adverse side effects as well as long-term damage which continues to have a detrimental impact on the patient’s quality of life, even after remission. It is believed that by modulating the tumor microenvironment (TME) post-treatment, not only may the efficacy of current treatments be improved, but such associated negative side effects, as well as further complications arising from treatment, including metastasis, have the potential to be reduced. Mediating the microenvironment is also considered to aid in repairing the damaged site post-treatment, subsequently making the conditions more favourable for promoting regenerative processes. This review provides a brief overview of the alterations in the TME resulting from the three main cancer treatments–chemotherapy, radiation therapy and surgery–and the most common tissue engineering methods currently used in an attempt to mediate the TME post-cancer therapy. Furthermore, it investigates new emerging technologies within this field and the progress of such methods in terms of reaching the clinical setting.

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Section: Biomaterial-based Scaffoldsmentioning

confidence: 99%

The road after cancer: biomaterials and tissue engineering approaches to mediate the tumor microenvironment post-cancer treatment

Westwood,

Nixon,

Emmerson

et al. 2024

Front. Biomater. Sci.

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“…Hyaluronic acid (HA) is a naturally occurring polymer and a glycosaminoglycan component of the extracellular matrix [ 171 ]. Overexpression of HA could indicate a poor prognosis, as it could be involved in progression, metastasis, and multidrug resistance [ 172 ]. A meta-analysis of breast cancer cases shows a correlation between high HA levels and lower disease-free survival, recurrence-free survival, and progression-free survival rates [ 173 ].…”

Section: The Unchartedmentioning

confidence: 99%

Targeting Breast Cancer: The Familiar, the Emerging, and the Uncharted Territories

Montazeri Aliabadi,

Manda,

Sidgal

et al. 2023

Biomolecules

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Breast cancer became the most diagnosed cancer in the world in 2020. Chemotherapy is still the leading clinical strategy in breast cancer treatment, followed by hormone therapy (mostly used in hormone receptor-positive types). However, with our ever-expanding knowledge of signaling pathways in cancer biology, new molecular targets are identified for potential novel molecularly targeted drugs in breast cancer treatment. While this has resulted in the approval of a few molecularly targeted drugs by the FDA (including drugs targeting immune checkpoints), a wide array of signaling pathways seem to be still underexplored. Also, while combinatorial treatments have become common practice in clinics, the majority of these approaches seem to combine molecularly targeted drugs with chemotherapeutic agents. In this manuscript, we start by analyzing the list of FDA-approved molecularly targeted drugs for breast cancer to evaluate where molecular targeting stands in breast cancer treatment today. We will then provide an overview of other options currently under clinical trial or being investigated in pre-clinical studies.

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“…The extracellular matrix (ECM) of soft connective tissues contains the highest levels of HA in the human body. Intracellular adhesion molecule (ICAM-1), cluster determinant 44 (CD44), and the receptor for hyaluronate-mediated motility (RHAMM) are a few examples of HA-specific receptors [18].…”

Section: Introductionmentioning

confidence: 99%

Relation of STAT3 rs1053005 Variation and miR-452-3p with Osteoarthritis Susceptibility and Severity and the Clinical Response to High-Molecular-Weight Hyaluronic Acid Injection in Osteoarthritis Patients

Wahba,

Mohamed,

Mehanna

et al. 2023

Diagnostics

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Polymorphisms in the 3′ untranslated region of STAT3 mRNA can derange STAT3 gene expression via modifying the microRNA-binding site. This study aimed to examine the impact of STAT3 rs1053005 variation and miR-452-3p expression on osteoarthritis (OA) susceptibility and severity and the efficacy of intra-articular high-molecular-weight hyaluronic acid (HMW-HA) injection as a therapy option for knee OA. Two hundred and fifty-eight OA patients and 200 healthy controls were enrolled in the study. STAT3 genotyping and STAT3 and miR-452-3p expression were carried out using allelic-discrimination PCR and quantitative real-time PCR. Functional assessment and pain evaluation were performed for all patients. Eighty-three patients received HMW-HA injections, and multiple follow-up visits were performed. STAT3 mRNA was upregulated, and expression was positively associated with plasmin, TNF-α, MMP-3, and STAT3 serum levels, whereas miR-452-3p was downregulated and negatively associated with the previously mentioned parameters in OA patients. Osteoarthritis patients had a lower prevalence of the minor allele of the rs1053005 variant (p < 0.001). Plasmin, TNF, MMP-3, and STAT3 mRNA and protein levels were significantly decreased, and miR-452-3p expression was significantly increased in the GG genotype compared to AG and AA genotypes. HMW-HA injection improved OA patients’ clinical scores with concomitant decreased STAT3 levels and enhanced expression of miR-452-3p. More efficient improvement was observed in rs1053005 AG + GG genotype carriers vs. AA genotype carriers. The G allele of STAT3 rs1053005 (A/G) polymorphism was associated with decreased OA susceptibility and severity and enhanced clinical response to HMW-HA injection, possibly via enhancing miR-452-3p binding and a subsequent decrease in STAT3 expression.

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Role of Hyaluronic Acid in Selected Malignant Neoplasms in Women

Cited by 8 publications

References 101 publications

The road after cancer: biomaterials and tissue engineering approaches to mediate the tumor microenvironment post-cancer treatment

The road after cancer: biomaterials and tissue engineering approaches to mediate the tumor microenvironment post-cancer treatment

Targeting Breast Cancer: The Familiar, the Emerging, and the Uncharted Territories

Relation of STAT3 rs1053005 Variation and miR-452-3p with Osteoarthritis Susceptibility and Severity and the Clinical Response to High-Molecular-Weight Hyaluronic Acid Injection in Osteoarthritis Patients

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