Role of hydration and water coordination in micellization of Pluronic block copolymers

Šturcová, Adriana; Schmidt, Pavel; Dybal, Jiřı́

doi:10.1016/j.jcis.2010.07.077

Cited by 29 publications

(18 citation statements)

References 59 publications

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“…Temperature can alter the thermodynamics and structure of Pluronic micellization in water [10]. Following the micellization, water molecules predominantly form hydrogen bonds with the PEO blocks, while the PPO micelle core is mostly dehydrated [11]. At higher temperatures, the hydration of the PEO blocks decreases [12], and the segregation between the PEO and PPO blocks increases [10].…”

Section: Introductionmentioning

confidence: 99%

Micellization Thermodynamics of Pluronic P123 (EO20PO70EO20) Amphiphilic Block Copolymer in Aqueous Ethylammonium Nitrate (EAN) Solutions

Alexandridis

2017

Polymers

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Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) block copolymers (commercially available as Pluronics or Poloxamers) can self-assemble into various nanostructures in water and its mixtures with polar organic solvents. Ethylammonium nitrate (EAN) is a well-known protic ionic liquid that is expected to affect amphiphile self-assembly due to its ionic nature and hydrogen bonding ability. By proper design of isothermal titration calorimetry (ITC) experiments, we determined the enthalpy and other thermodynamic parameters of Pluronic P123 (EO 20 PO 70 EO 20 ) micellization in aqueous solution at varied EAN concentration. Addition of EAN promoted micellization in a manner similar to increasing temperature, e.g., the addition of 1.75 M EAN lowered the critical micelle concentration (CMC) to the same extent as a temperature increase from 20 to 24 • C. The presence of EAN disrupts the water solvation around the PEO-PPO-PEO molecules through electrostatic interactions and hydrogen bonding, which dehydrate PEO and promote micellization. At EAN concentrations lower than 1 M, the PEO-PPO-PEO micellization enthalpy and entropy increase with EAN concentration, while both decrease above 1 M EAN. Such a change can be attributed to the formation by EAN of semi-ordered nano-domains with water at higher EAN concentrations. Pyrene fluorescence suggests that the polarity of the mixed solvent decreased linearly with EAN addition, whereas the polarity of the micelle core remained unaltered. This work contributes to assessing intermolecular interactions in ionic liquid + polymer solutions, which are relevant to a number of applications, e.g., drug delivery, membrane separations, polymer electrolytes, biomass processing and nanomaterial synthesis.

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Section: Introductionmentioning

confidence: 99%

Micellization Thermodynamics of Pluronic P123 (EO20PO70EO20) Amphiphilic Block Copolymer in Aqueous Ethylammonium Nitrate (EAN) Solutions

Alexandridis

2017

Polymers

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“…FTIR analysis is utilised to illustrate the chemical groups of HAp-MB and HAp-MB@TA, as shown in Figure 5. For HAp-MB (Figure 5(a)), absorbance bands located at 1,093 and 563 cm −1 are assigned to stretching vibration and bending vibration of PO 4 3− groups, respectively (Seabra et al , 2014; Son et al , 2012; Šturcová et al , 2010). Absorbance band centred at 3,408.6 cm −1 is ascribed to stretching vibration of the OH group of adsorbed water.…”

Section: Resultsmentioning

confidence: 99%

Enhanced generation efficiency of singlet oxygen for methylene blue released from hydroxyapatite-MB@tannic acid-Fe(III) ions

Wang

Shi

Zhang

et al. 2019

PRT

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Purpose The purpose of this paper is to improve the generation efficiency of singlet oxygen of methylene blue molecules through finely controlling their aggregation states in drug carriers. Design/methodology/approach As a photosensitiser in photodynamic therapy, methylene blue (MB) was loaded on citrate-modified hydroxyapatite (HAp) through an electrostatic interaction and followed by encapsulation of coordination complexes of tannic acid (TA) and Fe(III) ions. Ultraviolet-visible absorption spectrum of the supernatant after incubation of samples was recorded at certain time interval to investigate the release behaviour of MB. Photodynamic activity of MB was determined by the oxidation reaction of uric acid by singlet oxygen generated by MB under illumination. Findings Almost all MB molecules were immediately released from HAp-MB, whilst an initial burst release of MB from HAp-MB@TA was followed by a sustainable and pH-sensitised release. In comparison with HAp-MB, photocatalystic reduction of HAp-MB@TA by titanium dioxide hardly occurred under illumination, indicating the stability against reduction to leukomethylene blue in vitro. Generation efficiency of singlet oxygen by MB released from HAp-MB@TA was significantly higher than that from HAp-MB because of the control of TA and Fe(III) ions complexes on molecular structures of released MB. Originality/value A facile method was herein demonstrated to optimise the generation efficiency of singlet oxygen by controlling aggregation states of PS molecules and improve PDT efficiency to damage tumour tissues.

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“…The hydration envelopes make the molecular rearrangement required by the glass transition more difficult than it would be in absence of the H-bonds. Formation of the hydration envelopes in the aqueous solutions of POE as well as POE-POP block copolymers has been confirmed and investigated by a number of methods [48][49][50][51][52].…”

Section: ) Andmentioning

confidence: 91%

Epoxy networks and hydrogels prepared from α,ω-diamino terminated poly(oxypropylene)-b-poly(oxyethylene)-b-poly(oxypropylene) and polyoxypropylene bis(glycidyl ether)

Krakovský¹,

Martinez-Haya²,

Ferrer³

et al. 2015

European Polymer Journal

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Role of hydration and water coordination in micellization of Pluronic block copolymers

Cited by 29 publications

References 59 publications

Micellization Thermodynamics of Pluronic P123 (EO20PO70EO20) Amphiphilic Block Copolymer in Aqueous Ethylammonium Nitrate (EAN) Solutions

Micellization Thermodynamics of Pluronic P123 (EO20PO70EO20) Amphiphilic Block Copolymer in Aqueous Ethylammonium Nitrate (EAN) Solutions

Enhanced generation efficiency of singlet oxygen for methylene blue released from hydroxyapatite-MB@tannic acid-Fe(III) ions

Epoxy networks and hydrogels prepared from α,ω-diamino terminated poly(oxypropylene)-b-poly(oxyethylene)-b-poly(oxypropylene) and polyoxypropylene bis(glycidyl ether)

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