2017
DOI: 10.1021/acs.langmuir.7b02313
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Role of Hydrogen Bonding of Cyclodextrin–Drug Complexes Probed by Thermodiffusion

Abstract: Temperature gradient-induced migration of biomolecules, known as thermophoresis or thermodiffusion, changes upon ligand binding. In recent years, this effect has been used to determine protein-ligand binding constants. The mechanism through which thermodiffusive properties change when complexes are formed, however, is not understood. An important contribution to thermodiffusive properties originates from the thermal response of hydrogen bonds. Because there is a considerable difference between the degree of so… Show more

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Cited by 37 publications
(35 citation statements)
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“…The temperature dependence for S T observed in the case of TMAOH is similar to the typical behavior discussed in the introduction, while S T decreases with increasing temperature for TBAOH. This inverse behavior for S T is not common for aqueous systems, but it has been observed in some systems: ethanol/water, 38 crown ether/ water 39 and acetylsalicylic acid 40 and will be discussed with the analysis of D (T ) and D T (T ) data.…”
Section: Resultsmentioning
confidence: 80%
See 1 more Smart Citation
“…The temperature dependence for S T observed in the case of TMAOH is similar to the typical behavior discussed in the introduction, while S T decreases with increasing temperature for TBAOH. This inverse behavior for S T is not common for aqueous systems, but it has been observed in some systems: ethanol/water, 38 crown ether/ water 39 and acetylsalicylic acid 40 and will be discussed with the analysis of D (T ) and D T (T ) data.…”
Section: Resultsmentioning
confidence: 80%
“…In recent works 40,45 it was argued that the slopes of the temperature dependence for S T (T ) are related to the hydrophilicity of the solutes. For the uncharged systems they found that the change of the Soret coecient between a higher (e.g.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, various unmethylated cyclodextrins (CDs) and their corresponding complexes with acetylsalicylic acid (ASA) showed a similar behavior. The temperature dependence of the CDs was more pronounced than that of the CD+ASA complex, indicating a slightly less hydrophilic character of the complex [45]. Another reason for the slightly lower hydrophilicity of the complex might be the higher flexibility of the STV compared to STV+B, which was recently investigated by quasi elastic neutron scattering (QENS) [30].…”
Section: Change Upon Ligand Bindingmentioning
confidence: 99%
“…In contrast to log P, it can also be determined at temperatures other than RT and it can be used to describe the hydrophilicity of complexes. 18…”
Section: B Correlation With Log Pmentioning
confidence: 99%
“…down at higher concentrations. 17 Recently, Niether et al 18 related the empirical parameters in Eq. (1) with the number and the strength of hydrogen bonds.…”
Section: Introductionmentioning
confidence: 99%