2002
DOI: 10.1007/pl00012511
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Role of hydrogen peroxide and oxidative stress in healing responses

Abstract: Oxidative stress is a host defense mechanism whose involvement in maintaining homeostasis and/or inducing disease has been widely investigated over the past decade. Various reactive oxygen species (ROS) have been defined and the enzymes involved in generating and/or eliminating them have been widely studied. In this review we briefly discuss general mechanisms of oxidative stress and the oxidative stress response of the host. We focus primarily on hydrogen peroxide and summarize the systems involved in its for… Show more

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Cited by 228 publications
(169 citation statements)
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“…The plasmid encodes a fusion protein of the insert and an N-terminal extension containing a (His) 6 tag, enabling purification by nickel affinity chromatography. The construct was expressed in the JM109 strain of Escherichia coli.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The plasmid encodes a fusion protein of the insert and an N-terminal extension containing a (His) 6 tag, enabling purification by nickel affinity chromatography. The construct was expressed in the JM109 strain of Escherichia coli.…”
Section: Methodsmentioning
confidence: 99%
“…Thus, changes in the redox equilibrium influence a host of cell functions, including but not limited to growth, stress responses, differentiation, metabolism, cell cycle, communication, migration, gene transcription, ion channels, and immune responses (for reviews see Refs. [2][3][4][5][6]. Alterations in the redox equilibrium are reflected in changes of the glutathione/glutathione-disulfide ratio (GSH/ GSSG) and the reduced/oxidized thioredoxin ratio.…”
mentioning
confidence: 99%
“…In vivo, the coupled actions of diverse enzymes keep the concentration of this compound under the levels which may compromise the viability of a given organism [54,55]. However, under in vitro conditions the situation becomes quite different; hydrogen peroxide may become accumulated reaching high concentrations or it may require to be added to the reaction medium.…”
mentioning
confidence: 99%
“…hydrogen peroxide, formed in vivo as a product of two general mechanisms: enzymatic or non-enzymatic dismutation of superoxide anions. H 2 O 2 is a physiological bacteriostatic agent, and a key element in the defence mechanisms of inflammatory cells; however, it is also involved in multiple physiological and pathological processes, including atherosclerosis, hypertension, mutagenesis, and cancer [40]. H 2 O 2 may alter protein conformation by oxidation of cysteine and methionine residues and, as a secondary messenger and modulator of gene expression, H 2 O 2 can influence signal transduction pathways, leading to the synthesis of cytokines and growth factors, such as interleukin 6 (IL-6) [41] or TGF-b [42].…”
Section: Disscusionmentioning
confidence: 99%