Role of Hydrogen Sulfide in the Regulation of Cell Apoptosis

Ryazantseva, N. V.; Novitsky, V. V.; Starikova, E. G.; Клепцова, Л. А.; Jakushina, V. D.; Кайгородова, Е. В.

doi:10.1007/s10517-011-1420-y

Cited by 9 publications

(7 citation statements)

References 6 publications

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“…Many molecules have been described which may improve the cardioplegia solution performance. Hydrogen sulfide (H 2 S) is an endogenous gaseous mediator that exerts a broad range of physiological actions in mammalian tissues, such as participating in cellular homeostasis and protecting cells from necrosis, apoptosis, and oxidative stress [ 4 , 5 ]. In the heart, H 2 S has protective effects on myocardial ischemia-induced cell apoptosis [ 6 , 7 ], whereas its reduction in a cardiac injury model increases myocardial infarct size, suggesting a role for endogenous H 2 S production in preventing myocardial ischemia injury [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Sulfide Improves Cardiomyocyte Function in a Cardiac Arrest Model

et al. 2017

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BackgroundCardioplegic arrest is a common procedure for many types of cardiac surgery, and different formulations have been proposed to enhance its cardio-protective effect. Hydrogen sulfide is an important signaling molecule that has cardio-protective properties. We therefore studied the cardio-protective effect of hydrogen sulfide in cardiac cell culture and its potential therapeutic use in combination with cardioplegia formulations.Materials/MethodsWe added hydrogen sulfide donor GYY4137 to HL-1 cells to study its protective effect in nutrient starved conditions. In addition, we tested the potential use of GYY4137 when it is added into two different cardioplegia formulations: Cardi-Braun® solution and del Nido solution in an ex vivo Langendorff perfused rat hearts model.ResultsWe observed that eight-hour pre-treatment with GYY4137 significantly suppressed apoptosis in nutrient-starved HL-1 cells (28% less compared to untreated cells; p<0.05), maintained ATP content, and reduced protein synthesis. In ex vivo experiments, Cardi-Braun® and del Nido cardioplegia solutions supplemented with GYY4137 significantly reduced the pro-apoptotic protein caspase-3 content and preserved ATP content. Furthermore, GYY4137 supplemented cardioplegia solutions decreased the S-(5-adenosyl)-L-methionine/S-(adenosyl)-L-homocysteine ratio, reducing the oxidative stress in cardiac tissue. Finally, heart beating analysis revealed the preservation of the inter-beat interval and the heart rate in del Nido cardioplegia solution supplemented with GYY4137.ConclusionsGYY4137 preconditioning preserved energetic state during starved conditions, attenuating the cardiomyocytes apoptosis in vitro. The addition of GYY4137 to cardioplegia solutions prevented apoptosis, ATP consumption, and oxidative stress in perfused rat hearts, restoring its electrophysiological status after cardiac arrest. These findings suggested that GYY4137 sulfide donor may improve the cardioplegia solution performance during cardiac surgery.

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Section: Introductionmentioning

confidence: 99%

Hydrogen Sulfide Improves Cardiomyocyte Function in a Cardiac Arrest Model

et al. 2017

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“…A study on experimental rats, H 2 S inhalation was found to have a severe cytotoxic effect on the nasal epithelium [6] and olfactory epithelial necrosis and sloughing [7]. In human studies, H 2 S was also found to have a dose-dependent intensification of cell death via apoptosis and necrosis [11]. The intracellular acidification of nasal epithelial cells by high-dose H 2 S exposure and the inhibition of cytochrome oxidase at much lower H 2 S concentrations suggest that changes in intracellular pH play a secondary role in H 2 S-induced nasal injury [12].…”

Section: Discussionmentioning

confidence: 96%

Short-term effects of subchronic low-level hydrogen sulfide exposure on oil field workers

Mousa

2014

Environ Health Prev Med

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Objectives To investigate the short-term effects of lowlevel hydrogen sulfide (H 2 S) exposure on oil field workers. Materials and methods Observational study included 34 patients who work at an oil field. All patients were males with age range of 22-60 years (mean 37 years). The data were collected by systematic questionnaire about symptoms. The inclusion criteria of patients were symptoms related to inhalation of H 2 S gas in the oil field. The complaints should be frequent and relapsed after each gas exposure and disappeared when there was no gas exposure. Exclusion criteria were the symptoms which experienced with or without H 2 S exposure. The presence of H 2 S gas was confirmed by valid gas detector devices. Results The most frequent presenting symptom was nasal bleeding. It was revealed in 18 patients (52.9 %). This followed by pharyngeal bleeding, gum bleeding, and bloody saliva (mouth bleeding) which were encountered in five cases for each complaint (14.7 %). Other less frequent presenting symptoms were tongue bleeding, bloody sputum, headache, abdominal colic, pharyngeal soreness, fatigue, and sleepiness. Conclusions Nasal mucosa was the most vulnerable part to H 2 S effect. Inhalation of H 2 S produced upper respiratory tract epithelial damage that led to bleeding from nose, pharynx, gum, tongue, trachea, and bronchi. There were no complaints of asthmatic attack upon exposure to low level of H 2 S. Sunlight had a significant role in reduction of ambient air H 2 S level.

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“…Most commonly known as a toxic gas with a rotten egg smell, H 2 S has recently emerged as the third gasotransmitter, joining NO and CO in this important biological regulatory role . Over the past two decades, endogenous H 2 S and related polysulfides (H 2 S n ), produced via different enzymatic processes, have been implicated in a wide variety of biological processes, including cancer progression, cellular metabolism, neurological regulation, , cell death pathways, and the regulation of cardiovascular function . Three H 2 S-generating enzymes, cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST), are the primary producers of endogenous H 2 S and play a vital role in the aforementioned processes .…”

Section: Gasotransmitter Deliverymentioning

confidence: 99%

Metal Coordination Complexes as Therapeutic Agents for Ischemia-Reperfusion Injury

Bigham

Wilson

2023

J. Am. Chem. Soc.

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Ischemia-reperfusion injury (IRI), which describes the cell damage and death that occurs after blood and oxygen are restored to ischemic or hypoxic tissue, is a significant factor within the mortality rates of heart disease and stroke patients. At the cellular level, the return of oxygen triggers an increase in reactive oxygen species (ROS) and mitochondrial calcium ( m Ca 2+ ) overload, which both contribute to cell death. Despite the widespread occurrence of IRI in different pathological conditions, there are currently no clinically approved therapeutic agents for its management. In this Perspective, we will briefly discuss the current therapeutic options for IRI and then describe in great detail the potential role and arising applications of metal-containing coordination and organometallic complexes for treating this condition. This Perspective categorizes these metal compounds based on their mechanisms of action, which include their use as delivery agents for gasotransmitters, inhibitors of m Ca 2+ uptake, and catalysts for the decomposition of ROS. Lastly, the challenges and opportunities for inorganic chemistry approaches to manage IRI are discussed.

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Role of Hydrogen Sulfide in the Regulation of Cell Apoptosis

Cited by 9 publications

References 6 publications

Hydrogen Sulfide Improves Cardiomyocyte Function in a Cardiac Arrest Model

Hydrogen Sulfide Improves Cardiomyocyte Function in a Cardiac Arrest Model

Short-term effects of subchronic low-level hydrogen sulfide exposure on oil field workers

Metal Coordination Complexes as Therapeutic Agents for Ischemia-Reperfusion Injury

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