2010
DOI: 10.1021/jp105356q
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Role of Hydrolysis Degree in the Drug−Matrix Interactions of Nanosized Sol−Gel Titania Reservoirs for Epilepsy Treatment

Abstract: Nanostructured titania reservoirs were synthesized by the sol-gel method. An antiepileptic drug phenytoin was encapsulated for the targeted drug delivery. NMR studies confirmed that the drug does not undergo substantial modifications during the sol-gel process. The water/alkoxide ratio r w was varied from 2 to 24 to evaluate the role of hydrolysis degree on the drug-matrix interactions. The interactions were found to be of hydrogen-type between amine and carbonyl groups of phenytoin and hydroxyl groups of tita… Show more

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Cited by 7 publications
(17 citation statements)
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“…As it was discussed previously, the degree of titania surface coverage with hydroxyl groups (hydroxylation degree) plays an important role in the strength of the drug-matrix interaction, therefore affecting the profile of the drug liberation. 30 Quantification of the coverage by spectroscopic methods is not a trivial task, since a lot of signals in the spectrum overlap. The first attempt of comparative quantification was performed in ref 30, and here we improved the analysis.…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations
“…As it was discussed previously, the degree of titania surface coverage with hydroxyl groups (hydroxylation degree) plays an important role in the strength of the drug-matrix interaction, therefore affecting the profile of the drug liberation. 30 Quantification of the coverage by spectroscopic methods is not a trivial task, since a lot of signals in the spectrum overlap. The first attempt of comparative quantification was performed in ref 30, and here we improved the analysis.…”
Section: Resultsmentioning
confidence: 99%
“…30 Quantification of the coverage by spectroscopic methods is not a trivial task, since a lot of signals in the spectrum overlap. The first attempt of comparative quantification was performed in ref 30, and here we improved the analysis.…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…The solid state 13 C NMR study allowed us to determine that phenytoin is attached to the matrix without any changes in the structure and to establish what part of the molecule couples to the titania hydroxyl groups Lopez et al (2010). The comparison of the two spectra for pure phenytoin and the one encapsulated into the titania matrix (Figs.…”
Section: Phenytoin-titania Interactionsmentioning
confidence: 99%