Role of hygienic factors in the etiology of allergic disorders in children

Yeşil, Şule; Kan, Ahmet; Abdulmajed, Olkar; Bakırtaş, Arzu; Sultan, Nedim; Demirsoy, Sadık

doi:10.3906/sag-1603-22

Cited by 4 publications

(7 citation statements)

References 19 publications

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“…This supports data from a smaller case‐control study showing a nonsignificant lower H. pylori positivity among children with allergies compared with individuals without allergies: 13.9% (17/122) vs 22.4% (22/98), respectively . In contrast, 2 other case‐control studies showed a significantly lower seroprevalence of H. pylori among allergic children compared with individuals without allergies: 25.6% (23/90) vs 44.4% (40/90) and 20% (36/180) vs 60% (108/180), respectively . In addition, the latter study also demonstrated significantly higher serum IL‐10 levels in nonatopic subjects …”

Section: Clinical Manifestationssupporting

confidence: 85%

“…In contrast, 2 other case‐control studies showed a significantly lower seroprevalence of H. pylori among allergic children compared with individuals without allergies: 25.6% (23/90) vs 44.4% (40/90) and 20% (36/180) vs 60% (108/180), respectively . In addition, the latter study also demonstrated significantly higher serum IL‐10 levels in nonatopic subjects …”

Section: Clinical Manifestationsmentioning

confidence: 60%

“…Kato et al 11 15 and 20% (36/180) vs 60% (108/180), respectively. 16 In addition, the latter study also demonstrated significantly higher serum IL-10 levels in nonatopic subjects. 16…”

Section: Iron Deficiency Anemiamentioning

confidence: 66%

“…16 In addition, the latter study also demonstrated significantly higher serum IL-10 levels in nonatopic subjects. 16…”

Section: Iron Deficiency Anemiamentioning

confidence: 66%

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Helicobacter pyloriand some aspects of gut microbiota in children

2018

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Helicobacter pylori infection in children differs from infection in adults in many aspects. The rate of infection, epidemiology, clinical presentations and complications, the applicability of diagnostic tests, antibiotic resistance, treatment options, and success rates differ significantly. Due to all these differences, management guidelines for children and adults differ also substantially. In 2017, the Updated ESPGHAN and NASPGHAN Guidelines on the management of H. pylori infection in children were published, emphasizing the differences in clinical presentation and indications for treatment, stating that the primary goal of clinical investigation in children is to identify the cause of upper gastrointestinal symptoms rather than the presence of H. pylori infection. Therefore, the diagnosis should be based on upper endoscopy, and the "test and treat strategy" should not be used in children. Due to an increasing rate of antibiotic resistance worldwide, the updated guidelines recommend broader use of antimicrobial susceptibility testing for H. pylori strains in order to tailor eradication treatment accordingly. Moreover, treatment in children should be prescribed only when indicated and should be based on the rate of eradication in local populations aiming for treatment success above 90%. During the last two decades there has been a steady decrease in the rate of H. pylori infection in both children and adults in the Western world. Two recent publications studying the incidence of H. pylori infection confirmed that early childhood is a time for acquisition of infection both in industrialized and nonindustrialized countries. In addition, they showed that H. pylori could be acquired outside the family. In respect to the inverse association between H. pylori and allergy, a longitudinal study demonstrated that early exposure to H. pylori at any age was inversely associated with atopy and allergic conditions.

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Section: Clinical Manifestationssupporting

confidence: 85%

Section: Clinical Manifestationsmentioning

confidence: 60%

“…Kato et al 11 15 and 20% (36/180) vs 60% (108/180), respectively. 16 In addition, the latter study also demonstrated significantly higher serum IL-10 levels in nonatopic subjects. 16…”

Section: Iron Deficiency Anemiamentioning

confidence: 66%

“…16 In addition, the latter study also demonstrated significantly higher serum IL-10 levels in nonatopic subjects. 16…”

Section: Iron Deficiency Anemiamentioning

confidence: 66%

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Helicobacter pyloriand some aspects of gut microbiota in children

2018

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“…Daha sonra yapılan çalışmalarda hijyen hipotezinin biyolojik temelleri desteklenmiş; çocukluk çağı enfeksiyonlarının T helper (Th) 1 yanıtı artırdığı ve atopi gelişiminde önemli olan Th2 yanıtı baskıladığı gösterilmiştir (7)(8)(9)(10)(11). Hipotezin ilk ortaya atıldığı andan itibaren virüs (9,10,(12)(13)(14)(15)(16), bakteri (2,7,9,10,13,17) ya da parazit (3,(8)(9)(10)(11)13) olmak üzere çeşitli çocukluk çağı enfeksiyonları ile atopi arasındaki ilişki araştırılmış; lehte ve aleyhte birçok sonuçla tartışmaya günümüzde de devam edilmiştir (2,(17)(18)(19)(20)(21).…”

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The Role of Infections in Atopic Diseases in Children

Erdoğan¹,

Duru²,

Elevli³

et al. 2018

Haseki

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ÖzAmaç: Özellikle gelişmiş ülkelerde olmak üzere son 40 yıldır atopik hastalıkların prevalansında artış görülmektedir. Bu durum iyileşen yaşam koşulları nedeni ile enfeksiyonlara maruziyetin azalması ile açıklanmaktadır. Çalışmamızda bazı enfeksiyonların atopik hastalıklar üzerindeki etkisi araştırılmıştır.Yöntemler: Çalışmamıza atopik 50 hasta ile yaş ve cins olarak benzer 46 sağlam çocuk kontrol gurubu olarak alındı. Olguların deri testleri yapıldı ve serum immünoglobulin (Ig) E düzeyleri belirlendi. Hepatit A virüs (HAV), Toxoplasma gondii, Epstein-Barr virüs (EBV) ve sitomegalovirüs (SMV) seropozitivitelerini saptamak için serumda spesifik IgG belirlendi. Helicobacter pylori antijen pozitifliği gaitada arandı.Bulgular: Atopik çocuklarda anti-HAV IgG seropozitivitesi (%30,0) ve H. pylori antijen pozitifliği (%22,0) kontrollerden (sırası ile, %52,1; %47,8) anlamlı olarak daha düşük bulundu. T. gondii, EBV viral kapsid antijeni ve SMV IgG seropozitifliği açısından her iki grupta anlamlı istatistiksel farklılık saptanmadı. Sonuç: HAV ve H. pylori enfeksiyonları atopik hastalıklardan koruyucu enfeksiyonlar olabilir. Ancak genellenebilir sonuçlara ulaşmak için daha geniş ölçekli çalışmalara gereksinim vardır.AnahtarSözcükler:Atopi, alerji, enfeksiyon, hijyen, hepatit A virüs, helicobakter pylori Aim:Especially in the developed countries; there has been an increase in the prevalence of atopic diseases over the past 40 years. This is explained by the improved living conditions and reduced exposure to infections. In this study, effects of some infections on atopic diseases were investigated.Methods: Fifty atopic patients and 46 age-and sex-matched healthy children were included in the study. Skin prick test was performed and serum immunoglobulin (Ig) E levels were determined in all subjects. Serum-specific IgG was investigated to detect seropositivity of hepatitis A virus (HAV), Toxoplasma gondii, Epstein-Barr virus (EBV) and cytomegalovirus (CMV). In addition, Helicobacter pylori feacal antigen test was done.Results: Anti-HAV IgG seropositivity (30.0%) and H. pylori antigen positivity (22.0%) were significantly lower in atopic children than in controls (52.1%, 47.8%, respectively). There was no statistically significant difference between the two groups in seropositivities of T. gondii, EBV viral capsid antigen and CMV IgG. Conclusion:HAV and H. pylori may be protective infections in atopic patients. However, there is a need for larger scale studies to achieve generalizable results.

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Hygiene Hypothesis: What Is the Current Thinking?

Cingi

Muluk

2017

Curr Otorhinolaryngol Rep

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Role of hygienic factors in the etiology of allergic disorders in children

Cited by 4 publications

References 19 publications

Helicobacter pyloriand some aspects of gut microbiota in children

Helicobacter pyloriand some aspects of gut microbiota in children

The Role of Infections in Atopic Diseases in Children

Hygiene Hypothesis: What Is the Current Thinking?

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